The role of anaemia in oxidative and genotoxic damage in transfused β-thalassaemic patients

Ferro, Elisa; Visalli, Giuseppa; Rosa, Maria Angela La; Civa, Rosa; Papa, Gaetano Randazzo; D’Ascola, Domenico Giuseppe; Roccamo, Gaetano; Piraino, Beth; Salpietro, Carmelo; Pietro, Angela Di

doi:10.1080/10245332.2016.1244034

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…Ferro et al (10) argued that the higher hemoglobin levels provided by regular transfusions help limit oxidative damage. However, we detected no difference in the hemoglobin levels in the thalassemic group and no correlations between hemoglobin level and TAC and TOC levels.…”

Section: Discussionmentioning

confidence: 99%

The Total Antioxidant Capacity May Not Be Related to Bilirubin and Uric Acid Level in Patients With Beta Thalassemia

Karakaş¹,

Yılmaz²,

Çelik³

et al. 2020

J Istanb Fac Med

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Beta talasemi hastalarında inefektif eritropoez ve çoklu transfüzyonlardan kaynaklanan demir birikimi, hastaları oksidatif strese maruz bırakmaktadır. Bu çalışmada, beta talasemi hastalarında total antioksidan ve oksidan kapasiteleri ile bunların endojen antioksidanlar (bilirubin, ürik asid) arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya transfüzyon bağımlı 30, transfüzyon bağımlı olmayan 15 olmak üzere kırk beş beta talasemi hastası ve 20 sağlıklı birey katılmıştır. Analiz için total antioksidan ve total oksidan durum kitleri kullanılmıştır. Bulgular: Hastaların total antioksidan kapasitesi (TAK) sağlıklı bireylere göre anlamlı olarak yüksek saptanmıştır (2,75 vs. 2,10 mmol/L; p=0,01). Total bilirubin seviyesi transfüzyon bağımlı olmayan hastalarda, transfüzyon bağımlı hastalara oranla anlamlı olarak yüksek bulunmuştur (5,7±3,3 vs.1,9±1,4; p<0,001). Total antioksidan kapasite ile endojen antioksidan seviyeleri arasında anlamlı ilişki saptanmamıştır (p=0,20) Sonuç: Beta talasemi hastalarının total antioksidan kapasitesi, hastaların endojen antioksidan durumları ile direkt ilişkili olmayabilir.

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Section: Discussionmentioning

confidence: 99%

The Total Antioxidant Capacity May Not Be Related to Bilirubin and Uric Acid Level in Patients With Beta Thalassemia

Karakaş¹,

Yılmaz²,

Çelik³

et al. 2020

J Istanb Fac Med

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Genotoxic effect of iron overload and disease complications in transfused β thalassaemic patients

Ferro

Visalli

Rosa

et al. 2016

MUTAGE

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In previously reported studies, we observed significantly high genotoxicity biomarkers in regularly transfused thalassaemic patients, thus, in this study, we better investigated the genotoxic effect of iron overload and of thalassaemia complications, including their drug treatments. The assessment was performed in 64 regularly transfused thalassaemic patients using cytokinesis-block micronucleus and comet assays. All patients were splenectomised and undergoing iron chelation therapy. To reduce hypoxia-induced oxidative damage, the patients with haemoglobin levels <9.5 g/dL were excluded. Serum concentrations of ferritin, iron, transferrin and the percentage of transferrin saturation, as well as cardiac and hepatic T2* magnetic resonance imaging, were considered to evaluate serum and organ siderosis.All genotoxic biomarkers significantly differed between patients and healthy subjects. Iron intake via blood transfusions was inversely related to percentage of DNA in tail. The disease complications affecting endpoints were active Hepatitis C virus infection, drug therapy for osteoporosis (i.e. bisphosphonates) and hormone replacement therapy for hypogonadism.The results, highlighting the combined effect of iron overload and, mainly, disease complications, including their respective pharmacological treatments, confirmed the increased cancer risk in thalassaemic patients.

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The role of anaemia in oxidative and genotoxic damage in transfused β-thalassaemic patients

Abstract: Owing to the higher risk of cancer in the thalassaemic cohorts, specific genotoxicity/oxidative biomarkers should be monitored in order to ameliorate and formulate more personalized disease management.

Cited by 2 publications

References 42 publications

The Total Antioxidant Capacity May Not Be Related to Bilirubin and Uric Acid Level in Patients With Beta Thalassemia

The Total Antioxidant Capacity May Not Be Related to Bilirubin and Uric Acid Level in Patients With Beta Thalassemia

Genotoxic effect of iron overload and disease complications in transfused β thalassaemic patients

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