The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women : early- versus late-onset pre-eclampsia

Govender, Lucinda; Mackraj, Irene; Gathiram, P.; Moodley, J.

doi:10.5830/cvja-2012-003

Cited by 28 publications

(23 citation statements)

References 50 publications

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“…This finding suggests that sFlt-1 may be a good marker for earlyonset PE. Previous studies have supported the hypothesis that an earlier onset of PE corresponds with higher sFlt-1 levels [26,27]. However, there are still some discrepancies in the reported sFlt-1 protein levels between studies.…”

Section: Discussionmentioning

confidence: 91%

A Role of sFlt-1 in Oxidative Stress and Apoptosis in Human and Mouse Pre-Eclamptic Trophoblasts1

Jiang

Zou

et al. 2015

Biology of Reproduction

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Pre-eclampsia (PE) is a hypertensive disorder that occurs during pregnancy, and is a multifactorial disease. The antiangiogenic factor, soluble fms-like tyrosine kinase 1 (sFlt-1), has been reported to be important in the pathogenesis of PE, but the mechanism of its involvement remains unknown. To test the effects of sFlt-1 on pregnancy, we injected pregnant mice with exogenous mouse sFlt-1. After 18 days of gestation, higher blood pressure, proteinuria, and histological differences were observed compared with controls. Mitochondrial swelling inside the trophoblast cells in the placenta of sFlt-1-treated pregnant mice was observed by electron microscopy, which suggested a role of sFlt-1 in oxidative stress in trophoblasts in PE. Furthermore, apoptosis markers were upregulated in sFlt-1-treated mice. In conclusion, sFlt-1 appears to play a role in oxidative stress, which promotes apoptosis of trophoblasts. This may be an important mechanism in the development of PE.

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Section: Discussionmentioning

confidence: 91%

A Role of sFlt-1 in Oxidative Stress and Apoptosis in Human and Mouse Pre-Eclamptic Trophoblasts1

Jiang

Zou

et al. 2015

Biology of Reproduction

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“…Our findings support the hypothesis of common pathogenic factors in preeclampsia and CHD, particularly between early‐onset preeclampsia and severe CHD. The pathophysiologic pathway in early‐onset preeclampsia is probably different from preeclampsia close to term, which may explain that the association with severe CHD differed by subtypes of preeclampsia.…”

Section: Commentmentioning

confidence: 99%

Possible Common Aetiology behind Maternal Preeclampsia and Congenital Heart Defects in the Child: a Cardiovascular Diseases in Norway Project Study

Brodwall

Leirgul

Greve

et al. 2015

Paediatric Perinatal Epid

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“…Most previous studies on angiogenic and antiangiogenic factors were conducted in White participants and there is a paucity of information on other ethnic groups. 31,32 Black women were found to have slightly higher levels of PlGF, sEng, and sVEGFR-1 than White women and women of other races in one study 33 but in another study no difference in PlGF and sVEGFR-1 was found compared to White women. 34 A study of sVEGFR-1 levels by parity 35 also did not find significant differences in PlGF and sVEGFR-1 levels within the first or second pregnancies of Hispanic women compared to White women.…”

Section: Commentmentioning

confidence: 89%

“…3 In the last decade a two-stage pathogenic model has gained acceptance as the underlying pathophysiology of early-onset preeclampsia. 31,37-40 In the first stage, inadequate placentation due to shallow cytotrophoblastic invasion restricts blood supply to the placenta and creates a hypoxic placental environment in the first trimester. Oxidative stress then induces ischemic lesions to the placenta, which may promote the release of a variety of molecules including but not limited to PlGF, sEng, and sVEGFR-1 into maternal circulation.…”

Section: Commentmentioning

confidence: 99%

Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors

Yang

Pearl

DeLorenze

et al. 2016

American Journal of Obstetrics and Gynecology

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BACKGROUND Little is known about racial-ethnic differences in the distribution of maternal serum levels of angiogenic and antiangiogenic factors and their associations with early-onset preeclampsia. OBJECTIVE To investigate the distribution of mid-trimester maternal serum levels of placental growth factor, soluble endoglin, and soluble vascular endothelial growth factor receptor 1 and their associations with early-onset preeclampsia in Whites, Hispanics, and Blacks. STUDY DESIGN A population-based nested case-control design was used to identify cases and controls of White, Hispanic, and Black origin from a 2000 to 2007 live-birth cohort in five southern California counties. Cases included 197 women (90 Whites, 67 Hispanics, and 40 Blacks) with early-onset preeclampsia defined as hypertension and proteinuria with onset prior to 32 weeks according to hospital records. Controls included a random sample of 2,363 women without early-onset preeclampsia. Maternal serum specimens collected at 15-20 weeks of gestation as part of routine prenatal screening were tested for placental growth factor, soluble endoglin, and soluble vascular endothelial growth factor receptor 1. Serum levels of the three factors were log-normally distributed. Adjusted natural logarithmic means were compared between cases and controls and between racial-ethnic groups. Odds ratios and 95% confidence intervals derived from logistic regression models were calculated to measure the magnitude of the associations. RESULTS Cases showed lower adjusted logarithmic means of placental growth factor but higher adjusted logarithmic means of soluble endoglin than controls across all three groups (P < 0.05). Cases also had higher adjusted means of soluble vascular endothelial growth factor receptor 1 than controls in Whites (7.75 log pg/mL versus 7.52 log pg/mL, P < 0.05) and Hispanics (7.73 log pg/mL versus 7.40 log pg/mL, P < 0.05) but not in Blacks (7.85 log pg/mL versus 7.69 log pg/mL, P = 0.47). Blacks were found to have higher levels of placental growth factor in both cases and controls when compared to Whites and Hispanics (adjusted means: 4.69 log pg/mL and 5.20 log pg/mL in Blacks, 4.08 log pg/mL and 4.78 log pg/mL in Whites, and 3.89 log pg/mL and 4.70 log pg/mL in Hispanics, respectively, P < 0.05). Hispanic cases had the highest adjusted mean of soluble endoglin compared to White and Black cases (9.24 log pg/mL, 9.05 log pg/mL, and 8.93 log pg/mL, respectively, P < 0.05). The weakest association of early-onset preeclampsia with placental growth factor and soluble endoglin was observed in Blacks. The adjusted odds ratio per log pg/mL increase of the two analytes were 0.219 (95% confidence interval, 0.124-0.385)and 5.02 (95% confidence interval, 2.56-9.86) in Blacks in comparison to 0.048 (95% confidence interval, 0.026-0.088) and 36.87 (95% confidence interval, 17.00-79.96) in Whites (P < .05) and 0.028 (95% confidence interval, 0.013-0.060) and 86.68 (95% confidence interval, 31.46-238.81) in Hispanics (P < .05), respectively. As for soluble ...

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The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women : early- versus late-onset pre-eclampsia

Cited by 28 publications

References 50 publications

A Role of sFlt-1 in Oxidative Stress and Apoptosis in Human and Mouse Pre-Eclamptic Trophoblasts1

A Role of sFlt-1 in Oxidative Stress and Apoptosis in Human and Mouse Pre-Eclamptic Trophoblasts1

Possible Common Aetiology behind Maternal Preeclampsia and Congenital Heart Defects in the Child: a Cardiovascular Diseases in Norway Project Study

Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors

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