The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model

Hortu, İsmet; Özçeltik, Gökay; Karadadaş, Elif; Erbaş, Oytun; Yiğittürk, Gürkan; Ulukuş, Murat

doi:10.1007/s11596-020-2213-1

Cited by 12 publications

(14 citation statements)

References 33 publications

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“…Moreover, in this case, peritoneal macrophages have an increased ability to secrete chemotactic protein-1 of monocytes-MCP-1 [12], which may indicate an increased recruitment of macrophages and be one of the main points in the pathogenesis of endometriosis [13]. Evidence in favor of this is the data obtained in the abovementioned work using rats as a model object [10]. The authors showed that oxytocin not only lowers the level of VEGF, but also reduces proinflammatory activation, decreasing the level of MCP-1 and TNF-α [10].…”

Section: Introductionmentioning

confidence: 88%

“…Evidence in favor of this is the data obtained in the abovementioned work using rats as a model object [10]. The authors showed that oxytocin not only lowers the level of VEGF, but also reduces proinflammatory activation, decreasing the level of MCP-1 and TNF-α [10]. Macrophages carry out their protective function by phagocytosis, the secretion of cytokines and participation in the complement system.…”

Section: Introductionmentioning

confidence: 98%

“…Therefore, VEGF can be considered as a potential target for the treatment of endometriosis. It has been shown that the use of oxytocin leads to a decrease in its level and correlates with a decrease in ectopic foci of endometriosis in a rat model [10].…”

Section: Introductionmentioning

confidence: 99%

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Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization

Toniyan

Povorova²,

Gorbacheva³

et al. 2021

Biomedicines

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(1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton. In this study, we describe two clinical cases involving rare localization of extragenital endometriosis (umbilicus) and compare them with genital endometriosis of different localization (ovaries and uterus), as well as eutopic endometrium obtained with separate diagnostic curettage without confirmed pathology. (2) Methods: The relative content of actin and tubulin cytoskeleton proteins was determined by Western blotting, and the expression of genes encoding these proteins was determined by RT-PCR in the obtained intraoperative biopsies. The content of 5hmC was estimated by dot blot experiments, and the methylase/demethylase and acetylase/deacetylase contents were determined. (3) Results: The obtained results indicate that the content of the actin-binding protein alpha-actinin1 significantly increased (p < 0.05) in the groups with endometriosis, and this increase was most pronounced in patients with umbilical endometriosis. In addition, both the mRNA content of the ACTN1 gene and 5hmC content increased. It can be assumed that the increase in 5hmC is associated with a decrease in the TET3 demethylase content. Moreover, in the groups with extragenital endometriosis, alpha- and beta-tubulin content was decreased (p < 0.05) compared to the control levels. (4) Conclusions: In analyzing the results, further distance of ectopic endometrial foci from the eutopic localization may be associated with an increase in the content of alpha-actinin1, probably due to an increase in the expression of its gene and an increase in migration potential. In this case, a favorable prognosis can be explained by a decrease in tubulin content and, consequently, a decrease in the rate of cell division.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 98%

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Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization

Toniyan

Povorova²,

Gorbacheva³

et al. 2021

Biomedicines

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“…Notably, several studies suggested that there is no association of age with progression of endometriosis [40]. On the other hand, other studies suggest that typical lesions of endometriosis can increase over time [33,72]. Therefore, further research is needed, in order to determine the best approach at the proper timing for adolescent endometriosis.…”

Section: Management Of Endometriosis In Adolescence and Treatment Opt...mentioning

confidence: 99%

Medical and Behavioral Aspects of Adolescent Endometriosis: A Review of the Literature

et al. 2022

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The majority of young women will experience discomfort associated with menstrual cycles and miss out on education and social opportunities. Endometriosis, the presence of endometrial glands and stroma outside of uterus, is the most common cause of secondary dysmenorrhea and characterized by pain despite treatment with nonsteroidal anti-inflammatory drugs and hormonal agents. The true prevalence of adolescent endometriosis is not clear. Delay in diagnosis leads to persistent pain, affects quality of life, and potentially contributes to disease progression and subfertility. A laparoscopic diagnosis is the gold standard, but the surgical appearance may differ from adults, as endometriotic lesions are usually red or clear, making their identification a challenge for gynecologists who are unexperienced with endometriosis in adolescents. A personalized medical–surgical treatment is regarded as the most effective therapeutic strategy to achieve remission of symptoms, suppress disease progression, and protect future fertility. Studies have demonstrated how adolescent endometriosis negatively affects patients’ quality of life and psychosocial functioning. Development of therapeutic interventions targeting psychosocial function and quality of life is imperative for adolescent patients.

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“…Sucking stimulus triggers oxytocin release, which gives rise to milk ejection. In addition, sucking is responsible for the strong emotional connection between mother and newborn through the skin-to-skin contact [27][28][29]. Prolonged breastfeeding may increase the duration of postpartum amenorrhea and promote circulation of oxytocin [30].…”

mentioning

confidence: 99%

Effects of Breastfeeding on Endometriosis-Related Pain: A Prospective Observational Study

Porta¹,

Sangiuliano

Cavalli

et al. 2021

IJERPH

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Endometriosis is a gynecological estrogen-dependent disease whose commonest pain symptoms are dysmenorrhea, dyspareunia, and acyclic chronic pelvic pain (CPP). Hormonal changes occurring during breastfeeding seem to reduce pain and disease recurrence. The aim of this observational prospective study was to assess the effect of breastfeeding on pain and endometriotic lesions in patients with endometriosis and to evaluate a possible correlation between the duration of breastfeeding, postpartum amenorrhea, and pain. Out of 156 pregnant women with endometriosis enrolled, 123 who breastfed were included in the study and were monitored for 2 years after delivery; 96/123 exclusively breastfed for at least 1 month. Mode of delivery, type and duration of breastfeeding, intensity of pain symptoms, and lesion size before pregnancy and during the 24-month follow-up were analyzed. All patients experienced a significant reduction in dysmenorrhea proportional to the duration of breastfeeding. CPP was significantly reduced only in women who exclusively breastfed. No significant improvement in dyspareunia was observed. Ovarian endometriomas were significantly reduced. Therefore, breastfeeding, particularly if exclusive, may cause improvement in dysmenorrhea and CPP proportional to the duration of breastfeeding, as well as a reduction in the size of ovarian endometriomas.

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The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model

Cited by 12 publications

References 33 publications

Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization

Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization

Medical and Behavioral Aspects of Adolescent Endometriosis: A Review of the Literature

Effects of Breastfeeding on Endometriosis-Related Pain: A Prospective Observational Study

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