2014
DOI: 10.1515/jpem-2013-0355
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The role of anti-Mullerian and inhibin B hormones in the evaluation of 46,XY disorders of sex development

Abstract: AMH and inhibin B are valuable, and reliable noninvasive parameters for the detection of functioning testicular tissues in prepubertal patients.

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Cited by 14 publications
(22 citation statements)
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“…Hypergonadotropic hypogonadism was not always present during the postnatal gonadotropin surge, indicating that FSH and LH have high specificity but low sensitivity to predict gonadal failure, as previously described [Morel et al, 2002]. It has been proposed that testosterone, anti-müllerian hormone, and inhibin B should be measured instead [Hafez et al, 2014]. Though detection of the latter two was not available in our service, low testosterone levels in all patients during minipuberty and impaired testosterone response to hCG stimulation without increase in testosterone precursors in most infants were suggestive of the diagnosis.…”
Section: Discussionmentioning
confidence: 79%
“…Hypergonadotropic hypogonadism was not always present during the postnatal gonadotropin surge, indicating that FSH and LH have high specificity but low sensitivity to predict gonadal failure, as previously described [Morel et al, 2002]. It has been proposed that testosterone, anti-müllerian hormone, and inhibin B should be measured instead [Hafez et al, 2014]. Though detection of the latter two was not available in our service, low testosterone levels in all patients during minipuberty and impaired testosterone response to hCG stimulation without increase in testosterone precursors in most infants were suggestive of the diagnosis.…”
Section: Discussionmentioning
confidence: 79%
“…Therefore, one clinical implication of our normative model is its potential use as a reference for a healthy population in assessing the role of inhibin B as a pre-pubertal marker of Sertoli cell function. This has a number of potential clinical implications, including the assessment of functioning testicular tissue in hypogonadotrophic hypogonadism, anorchia and disorders of sexual development [ 2 , 31 ]. We have reported our experience in assessing inhibin B as a marker of gonadotoxicity in young males treated for malignancy in childhood [ 11 ], but the interpretation was limited by the absence of a normative model for inhibin B in childhood.…”
Section: Discussionmentioning
confidence: 99%
“…Like AMH, inhibin B is a useful serum marker for the existence of functional testicular tissue. A recent study in DSD patients that assessed cut-off levels for inhibin B to discriminate between the absence and presence of testicular tissue reported a positive predictive value of 86% and a negative predictive value of 90% for inhibin B levels <41.9 pg/mL [Hafez et al, 2014]. Serum inhibin B is low in patients with partial testicular dysgenesis ( Fig.…”
Section: Dysgenetic Dsdmentioning
confidence: 94%
“…In patients with dysgenetic DSD, serum AMH is low or undetectable ( Fig. 2 ), reflecting the number of [Rey et al, 1999;Josso et al, 2012;Lindhardt Johansen et al, 2013;Hafez et al, 2014]. Because of absent or insufficient AMH action during fetal life, these patients present with müllerian remnants.…”
Section: Dysgenetic Dsdmentioning
confidence: 99%