The role of antiparasite treatment experiments in assessing the impact of parasites on wildlife

Pedersen, Amy B.; Fenton, Andy

doi:10.1016/j.pt.2015.02.004

Cited by 80 publications

(75 citation statements)

References 81 publications

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“…Parasitism, hormonal changes and behavioural time reallocation can alter body condition and lead to reductions in fitness [29][30][31][32]. For example, low body condition in parasitized Iberian hares (Lepus granatensis) contributes to reduced antipredator defence and higher host mortality [33].…”

Section: Introductionmentioning

confidence: 99%

Changes in physiological stress and behaviour in semi-free-ranging red-capped mangabeys ( Cercocebus torquatus ) following antiparasitic treatment

2016

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Parasites are ubiquitous in wildlife populations, but physiological and behavioural responses of hosts to infection are difficult to measure. We experimentally treated semi-free-ranging red-capped mangabeys (Cercocebus torquatus) in Nigeria with antiparasitic drugs and examined subsequent changes in glucocorticoid production and individual behaviour. Because both parasites and stress impact energy balance and health, we measured (i) behavioural time re-allocation via activity budgets, (ii) social relationships (e.g. social connectivity and dominance hierarchy stability) and (iii) body condition. We collected triplicate faecal samples (n ¼ 441) from 49 individuals prior to and following treatment. Cortisol levels fluctuated in parallel with parasite abundance. Elevations in cortisol, but not parasitism, were related to reduced body condition. Behaviour also shifted according to infection status, with uninfected individuals spending more time foraging and less time resting and vigilant compared with when they were infected. Time spent feeding, travelling or socializing did not differ between pre-and posttreatment time periods. Group cohesion, but not dominance stability, changed following treatment, suggesting parasite-induced social avoidance. Together, these findings show a coordinated response to infection that promotes host tolerance through stress and energy conservation, reduces transmission risk and increases protection when infected hosts are vulnerable.

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Section: Introductionmentioning

confidence: 99%

Changes in physiological stress and behaviour in semi-free-ranging red-capped mangabeys ( Cercocebus torquatus ) following antiparasitic treatment

2016

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“…Of the 13 scoping reviews, 10 provided some details of the search strategy, although most lacked sufficient detail to repeat the searches. Three reviews included vote-counting (Brearley et al., 2013, Fagre et al., 2015, Pedersen and Fenton, 2015). These reviews weighted all included studies equally and failed to account for either the size of the studies or the magnitude of study effects.…”

Section: Resultsmentioning

confidence: 99%

“…In the single paper that was chosen for an extended analysis, Pedersen and Fenton 2015, as no details of search strategy or inclusion criteria were provided, a systematic search resulted in an additional thirty-one papers missing from the published literature review (see Supplement file). Vote-counting is performed and the authors discuss an apparent lack of non-significant/negative evidence across insect-specific treatments where only a small number of single studies show positive effects.…”

Section: Resultsmentioning

confidence: 99%

“…And finally, as an example of how a lack of transparency, comprehensiveness and critical appraisal and the use of vote-counting can severely limit the usefulness of a review, one paper, Pedersen and Fenton (2015) is examined in depth.…”

Section: Methodsmentioning

confidence: 99%

“…The following is the supplementary data related to this article:Relevant studies omitted from Pedersen and Fenton (2015).…”

Section: Supplementary Datamentioning

confidence: 99%

See 2 more Smart Citations

On the benefits of systematic reviews for wildlife parasitology

Haddaway

Watson

2016

International Journal for Parasitology: Parasites and Wildlife

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Systematic reviews and meta-analyses are widely accepted as the best means to synthesise quantitative or qualitative scientific evidence. Many scientific fields have embraced these more rigorous review techniques as a means to bring together large and complex bodies of literature and their data. Unfortunately, due to perceived difficulties and unfamiliarity with processes, other fields are not using these options to review their literature. One way to provide guidance for a specific field is to examine critically recent reviews and meta-analyses and to explain the advantages and disadvantages of the various review techniques. In this paper, we examine review papers in the emerging field of wildlife parasitology and compare five different literature review types—configurative narrative review, aggregative scoping review, aggregative literature review, aggregative meta-analysis, and aggregative systematic review. We found that most literature reviews did not adequately explain the methodology used to find the literature under review. We also found that most literature reviews were not comprehensive nor did they critically appraise the literature under review. Such a lack severely reduces the reliability of the reviews. We encourage all authors to consider using systematic reviews in the future, and for authors and peer-reviewers to be aware of the limitations of non-systematic reviews.

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Validation of an LC–MS/MS method for assessment of fenbendazole sulfone drug residue in northern bobwhite liver

Henry

Patel

Henry

et al. 2023

Biomedical Chromatography

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The Northern Bobwhite (Colinus virginianus) is an economically important game bird within the Rolling Plains Ecoregion. Within this region, bobwhite is experiencing extreme cyclic population fluctuations which are resulting in a net decline in total population. It is suspected that within this region two helminth parasites, an eyeworm (Oxyspirura petrowi) and a cecal worm (Aulonocephalus pennula), are contributing to this phenomenon. However, this has been difficult to study as the primary mode of investigation would be the deployment of anthelmintic treatment. Unfortunately, no registered treatments for wild bobwhite currently exist. Thus, utilizing an anthelmintictreatment for wild bobwhite would require registration of that treatment with the U.S. Food and Drug Administration (FDA). As bobwhite are game birds that are hunted, they are considered food-producing animals to the FDA, and as such require the assessment for the withdrawal of the drug residues to be assessed for human food safety. In this study, we optimized and validated a bioanalytical method for the quantification of fenbendazole sulfone in bobwhite following the U.S. FDA Center for Veterinary Medicine Guidance for Industry #208 [VICH GL 49 (R)] for assessment of fenbendazole sulfone drug residue in Northern bobwhite liver. The official method for quantifying fenbendazole sulfone in domestic chicken (Gallus gallus) was adapted for use in bobwhite. The validated method quantitation range is 2.5-30 ng/mL for fenbendazole with an average recovery of 89.9% in bobwhite liver.

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The role of antiparasite treatment experiments in assessing the impact of parasites on wildlife

Cited by 80 publications

References 81 publications

Changes in physiological stress and behaviour in semi-free-ranging red-capped mangabeys ( Cercocebus torquatus ) following antiparasitic treatment

Changes in physiological stress and behaviour in semi-free-ranging red-capped mangabeys ( Cercocebus torquatus ) following antiparasitic treatment

On the benefits of systematic reviews for wildlife parasitology

Validation of an LC–MS/MS method for assessment of fenbendazole sulfone drug residue in northern bobwhite liver

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