The role of antithrombin in diagnosis and treatment of sepsis

Lopatin, A.; Red'kin, Iu V; Samoylenko, V. V.; Petrovskaya, E. L.; Molchanov, I. V.

doi:10.17116/anaesthesiology201803119

Cited by 5 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Некробиотические последствия тканевой гипоперфузии ведут к формированию синдрома эндогенной токсемии [23]. Известно, что воспалительная реакция на любое повреждение или некроз представляет собой единый воспалительно-коагуляционный ответ [24,25]. Уменьшение гемокоагуляционных нарушений при тяжелом течении ОПМП несомненно скажется на улучшении микроциркуляции и перфузии органов и тканей.…”

Section: Introductionunclassified

Hemocoagulation Disorders and Intoxication in Severe Acute Post-Manipulation Pancreatitis in the Experiment

Prudkov,

Rantsev,

Sarapultsev

et al. 2024

Урал. мед. журнал

View full text Add to dashboard Cite

Introduction. Acute post-manipulation pancreatitis (APMP) is a frequent complication aﬅer interventions on the major duodenal papilla. The APMP incidence reaches 15 %, of which 5–10 % are severe. The goal of the research is to determine the possibility of correcting hemocoagulation disorders and reducing endogenous toxemia syndrome severity in APMP.Materials and methods. A comparative study was performed in 40 animals (nonlinear albino rats) with severe acute pancreatitis on APMP experimental model. L-17 compound from a new group of organic compounds substituted thiadiazines at a daily dose of 40 mg/kg was used.Results. The development of hemocoagulation disorders and severe toxemia in animals with an experimental model of APMP has been shown. The indicators of the severity of hemocoagulation disorders and toxemia were studied in experimental APMP against the background of the introduction of the compound L-17 from the group of substituted thiadiazines.Discussion. The course of APMP in the experiment is accompanied by the development of severe hemocoagulation disorders and severe toxemia. Eﬀective indicators reﬂecting the severity of APLP are D-dimers (hemocoagulation) and albumin binding capacity (toxemia).Conclusion. The course of experimental severe APMP is accompanied by pronounced hemocoagulation disorders development involved in the pathogenesis and progression of multiple organ dysfunction, that is characterized by a high level of endogenous toxemia. The course of experimental APMP against the background of the introduction of the compound L-17 is marked by a decrease in the severity of hemocoagulation disorders and the level of endogenous toxemia.

show abstract

Section: Introductionunclassified

Hemocoagulation Disorders and Intoxication in Severe Acute Post-Manipulation Pancreatitis in the Experiment

Prudkov,

Rantsev,

Sarapultsev

et al. 2024

Урал. мед. журнал

View full text Add to dashboard Cite

show abstract

Impact of gastrointestinal insufficiency on survival of children with sepsis

Tretiakova,

Shen,

Tretiakov

2023

Anaes. i reanim.

View full text Add to dashboard Cite

Septic shock

Бицадзе

Sukontseva

Akinshina

et al. 2020

Akušerstvo, ginekologiâ i reprodukciâ

View full text Add to dashboard Cite

The problem of sepsis and septic shock has recently become more and more actual. In obstetrics and gynaecology, the number of cases of sepsis has more than doubled over the past 10 years. The review examines the clinical forms of septic conditions, risk factors, pathogenesis of sepsis and septic shock, the main pathogens of septic conditions. Special attention is paid to neonatal sepsis. The relationship between septic shock and viral infections is considered in the context of the novel coronavirus infection caused by SARS-CoV-2 (COVID-19) pandemic. Hemostasis abnormalities have been demonstrated in patients with septic shock, including disseminated intravascular coagulation (DIC). The importance of determining the level of ADAMTS-13 to refine the forecast is discussed.

show abstract

The role of antithrombin in diagnosis and treatment of sepsis

Cited by 5 publications

References 54 publications

Hemocoagulation Disorders and Intoxication in Severe Acute Post-Manipulation Pancreatitis in the Experiment

Hemocoagulation Disorders and Intoxication in Severe Acute Post-Manipulation Pancreatitis in the Experiment

Impact of gastrointestinal insufficiency on survival of children with sepsis

Septic shock

Contact Info

Product

Resources

About