The role of bariatric surgery in the treatment of diabetes

Tham, Ji Chung; Howes, Noah; Roux, Carel W. le

doi:10.1177/2040622313513313

Cited by 22 publications

(18 citation statements)

References 74 publications

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“…Food intake is reduced following bariatric surgery as a consequence of either reducing the size of stomach through insertion of a gastric band, or the removal of a part of the stomach or reducing the length of the small intestine. Long-term studies indicate this type of surgery, is not effective for weight loss [5], but also ameliorate a variety of obesity-related diseases such as DM and CVD [8]. However, some adverse effects may be expected due to the magnitude of the procedure [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

et al. 2020

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Different adipokines secreted from adipose tissue, exert a range of physiological effects. The aim of present systematic review and meta-analysis was to critically investigate the consequence of bariatric surgery on circulating adipokines, that is, adiponectin, leptin, visfatin, resistin, plasminogen activator inhibitor, and chemerin. After systematically checking the following electronic databases: ISI web of Science, Scopus and PubMed without limitation in time and language up to February 2019, a pool based on a random effect model was established. Eighty-five eligible studies were entered for quantitative analysis. Our meta-analysis revealed that circulating adiponectin increased significantly after bariatric surgery [Standardized mean difference (SMD)=1.401, 95% CI: 1.101, 1.701, p<0.001]; whilst leptin (SMD=–2.178, 95% CI: –2.433, –1.923, p<0.001), PAI-1 (–14.928 ng/ml 95% CI: –21.794, –8.063, p<0.001), and chemerin (–50.238 ng/ml 95% CI: –85.708, –14.768, p<0.001) decreased. However, serum visfatin (2.05 ng/ml, 95% CI: –5.07, 9.17, p=0.573) and resistin (–2.080 ng/ml, 95% CI: –5.352, 1.192, p=0.21) were unchanged. In conclusion, bariatric surgery is associated with a reduction in specific adipokines including leptin, chemerin, and PAI-1, whereas adiponectin is raised, adaptations that could be indicative of improved fat mass and function.

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Section: Introductionmentioning

confidence: 99%

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

et al. 2020

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“…Bariatric surgery can lead to significant improvement of type 2 diabetes mellitus (T2DM) in morbidly obese patients [ 1 , 2 ]. A meta-analysis by Buchwald et al [ 3 ] has shown that laparoscopic adjustable gastric banding (LAGB) and biliopancreatic diversion (BPD) induces remission of T2DM in 50% and up to 95% of bariatric T2DM patients, respectively.…”

Section: Introductionmentioning

confidence: 99%

Insulin Sensitivity and Secretion in Obese Type 2 Diabetic Women after Various Bariatric Operations

et al. 2016

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Objective: To compare the effects of biliopancreatic diversion (BPD) and laparoscopic gastric banding (LAGB) on insulin sensitivity and secretion with the effects of laparoscopic gastric plication (P). Methods: A total of 52 obese women (age 30-66 years) suffering from type 2 diabetes mellitus (T2DM) were prospectively recruited into three study groups: 16 BPD; 16 LAGB, and 20 P. Euglycemic clamps and mixed meal tolerance tests were performed before, at 1 month and at 6 months after bariatric surgery. Beta cell function derived from the meal test parameters was evaluated using mathematical modeling. Results: Glucose disposal per kilogram of fat free mass (a marker of peripheral insulin sensitivity) increased significantly in all groups, especially after 1 month. Basal insulin secretion decreased significantly after all three types of operations, with the most marked decrease after BPD compared with P and LAGB. Total insulin secretion decreased significantly only following the BPD. Beta cell glucose sensitivity did not change significantly post-surgery in any of the study groups. Conclusion: We documented similar improvement in insulin sensitivity in obese T2DM women after all three study operations during the 6-month postoperative follow-up. Notably, only BPD led to decreased demand on beta cells (decreased integrated insulin secretion), but without increasing the beta cell glucose sensitivity.

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“…T2DM rate increases alongside with increment of obesity over the world. An estimate of 170 million people affected by T2DM worldwide was recently reported [5]. The first treatment of T2DM is surely lifestyle modification alongside with pharmacotherapy.…”

Section: Introductionmentioning

confidence: 99%

Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

Fallahi-shahabad

Mazidi

Tavasoli

et al. 2016

Indian J Gastroenterol

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The role of bariatric surgery in the treatment of diabetes

Cited by 22 publications

References 74 publications

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis

Insulin Sensitivity and Secretion in Obese Type 2 Diabetic Women after Various Bariatric Operations

Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

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