The role of bariatric surgery in the treatment of type 2 diabetes mellitus

Leong, Wen B.; Taheri, Shahrad

doi:10.4997/jrcpe.2012.301

Cited by 12 publications

(9 citation statements)

References 41 publications

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“…To date, the most effective treatment for both weight reduction and glycaemic control is bariatric (metabolic) surgery, with a 58% to 95% reported rate of T2D remission, particularly following either a biliopancreatic diversion (BPD) or a Roux‐en‐Y gastric bypass (RYGB). The percentage of patients achieving T2D remission varies, depending on how diabetes remission is defined .…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

Insulin‐associated weight gain in obese type 2 diabetes mellitus patients: What can be done?

Brown

Guess

Dornhorst

et al. 2017

Diabetes Obesity Metabolism

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Insulin therapy (IT) is initiated for patients with type 2 diabetes mellitus when glycaemic targets are not met with diet and other hypoglycaemic agents. The initiation of IT improves glycaemic control and reduces the risk of microvascular complications. There is, however, an associated weight gain following IT, which may adversely affect diabetic and cardiovascular morbidity and mortality. A 3 to 9 kg insulin-associated weight gain (IAWG) is reported to occur in the first year of initiating IT, predominantly caused by adipose tissue. The potential causes for this weight gain include an increase in energy intake linked to a fear of hypoglycaemia, a reduction in glycosuria, catch-up weight, and central effects on weight and appetite regulation. Patients with type 2 diabetes who are receiving IT often have multiple co-morbidities, including obesity, that are exacerbated by weight gain, making the management of their diabetes and obesity challenging. There are several treatment strategies for patients with type 2 diabetes, who require IT, that attenuate weight gain, help improve glycaemic control, and help promote body weight homeostasis. This review addresses the effects of insulin initiation and intensification on IAWG, and explores its potential underlying mechanisms, the predictors for this weight gain, and the available treatment options for managing and limiting weight gain.

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Section: Therapeutic Interventionsmentioning

confidence: 99%

Insulin‐associated weight gain in obese type 2 diabetes mellitus patients: What can be done?

Brown

Guess

Dornhorst

et al. 2017

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

show abstract

“…The most common procedures carried out in the NHS are laparoscopic adjustable gastric banding , laparoscopic Rouxen-Y gastric bypass and laparoscopic sleeve gastrectomy. 8,9 A study by Angrisani et al estimated that the total number of bariatric procedures performed worldwide in 2013 was 468,609, of which 95.7% were carried out laparoscopically. The most commonly performed procedure was Roux-en-Y gastric bypass (45%); followed by sleeve gastrectomy (37%), which is the most frequently performed procedure in the USA; and adjustable gastric band (10%).…”

Section: Bariatric Surgerymentioning

confidence: 99%

“…8,9 Besides body weight reduction, surgery also results in an improvement of insulin resistance or remission of type 2 diabetes. 17 Thus, bariatric interventions are the most effective treatments for patients with obesity complicated type 2 diabetes.…”

Section: Bariatric Surgerymentioning

confidence: 99%

“…It is widely demonstrated that weight reduction is essential for patients with metabolic syndrome and other obesity-related comorbidities. 9,15,16 Therefore, to target body weight reduction, most of the treatments are based on dietary interventions, lifestyle modifi cations, anti-obesogenic drugs, bariatric surgery and a combination of methods. 11,13,14 By far, bariatric surgery is the most effective single therapy.…”

Section: Metabolic Syndromementioning

confidence: 99%

“…Bariatrics has been shown to exceed the success of other treatment modalities that are available today against obesity and its comorbidities. 7,8,9 Compared to lifestyle interventions, glycaemic control, dyslipidaemia, cardiovascular risk and quality of life are more likely to improve after bariatric surgery. In addition, bariatric surgery is a long-term cost-effective successful intervention.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bariatric Surgery as a Treatment for Metabolic Syndrome

Cordero

Oben

2017

Journal of the Royal College of Physicians of Edinburgh

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Obesity is the pandemic of the 21st century. Obesity comorbidities, including hypertension, dyslipidaemia and glucose intolerance de ne metabolic syndrome, which increases mortality risk and decreases the quality of life. Compared with lifestyles (diet and physical activity) and pharmacological interventions, bariatric surgery is by far the most effective treatment for obesity and its comorbidities. This minimally invasive surgical treatment is based on an increase of satiety (by hormonal regulation and decreasing stomach volume) or a decrease in nutrient retention (gastric and/or intestinal resection). Bariatric surgery has widely demonstrated a bene cial effect on excess body weight loss, cardiovascular risk, dyslipidaemia, non-alcoholic fatty liver disease or glucose homeostasis, among other obesity-related metabolic diseases. This review describes current efforts for the implementation of bariatric surgery in metabolic syndrome, which are mainly focused on the formulation of key de nition criteria for targeting the most suitable population for this therapeutic approach. Patients should undergo appropriate nutritional and psychological follow up in order to achieve and maintain weight loss milestones and a healthy metabolic status.Keywords: bariatric surgery, diabetes, dyslipidaemia, hypertension, metabolic syndrome, obesity Declaration of interests: No confl ict of interests declared AbstractIntroduction

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Obesity and Type 2 Diabetes

Khalil

Taheri

2014

Molecular Mechanisms Underpinning the Development of Obesity

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The role of bariatric surgery in the treatment of type 2 diabetes mellitus

Cited by 12 publications

References 41 publications

Insulin‐associated weight gain in obese type 2 diabetes mellitus patients: What can be done?

Insulin‐associated weight gain in obese type 2 diabetes mellitus patients: What can be done?

Bariatric Surgery as a Treatment for Metabolic Syndrome

Obesity and Type 2 Diabetes

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