The role of biomaterials in overcoming barriers to regeneration in the central nervous system

Führmann, Tobias; Shoichet, Molly S.

doi:10.1088/1748-605x/aac2f6

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…Regenerative medicine has recently begun to offer new paradigms in the treatment of CNS disorders, with many regenerative strategies underpinned by biomaterial-based approaches [5]. Biomaterials have been used to enhance the survival of therapeutic cells transplanted into the CNS [6], provide essential structural or mechanical support [7], and act as depots to enable local drug or gene therapy delivery [8,9].…”

Section: Main Textmentioning

confidence: 99%

Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine

et al. 2020

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Section: Main Textmentioning

confidence: 99%

Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine

et al. 2020

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“…Ghuman and Modo [76] propose that, moreover, the ideal biomaterial must protect the implanted cells from the host response and interact positively with the immune response. In this way, the incorporation of different biomaterials in cell therapy targeting the CNS has been shown to promote cell survival, integration, and differentiation [77].…”

Section: Biomaterials In Nose-to-brain Therapiesmentioning

confidence: 99%

Nose-to-Brain: The Next Step for Stem Cell and Biomaterial Therapy in Neurological Disorders

Villar-Gómez

Ojeda-Hernández

López-Muguruza

et al. 2022

Cells

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Neurological disorders are a leading cause of morbidity worldwide, giving rise to a growing need to develop treatments to revert their symptoms. This review highlights the great potential of recent advances in cell therapy for the treatment of neurological disorders. Through the administration of pluripotent or stem cells, this novel therapy may promote neuroprotection, neuroplasticity, and neuroregeneration in lesion areas. The review also addresses the administration of these therapeutic molecules by the intranasal route, a promising, non-conventional route that allows for direct access to the central nervous system without crossing the blood–brain barrier, avoiding potential adverse reactions and enabling the administration of large quantities of therapeutic molecules to the brain. Finally, we focus on the need to use biomaterials, which play an important role as nutrient carriers, scaffolds, and immune modulators in the administration of non-autologous cells. Little research has been conducted into the integration of biomaterials alongside intranasally administered cell therapy, a highly promising approach for the treatment of neurological disorders.

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“…This tissue loss results in a hostile environment for transplanted cells and causes deficient engraftment with poor cell viability (Boisserand et al, 2016). In recent years, the incorporation of different biomaterials to cell therapy in CNS has shown to promote cell survival, integration, and differentiation (Führmann and Shoichet, 2018). In this way, chitosan-based biomaterials have been employed in combination with stem/precursor cells to build a way to neuro-regeneration ( Table 3).…”

Section: Chitosan-based Materials and Cell Therapy To The Cnsmentioning

confidence: 99%

“…However, these stem cells need a neurogenic microenvironment to achieve migration and differentiation (Gáge and Temple, 2013). Recent advances in biomaterials have encouraged the search to overcome these challenges, either on their own or as vehicles for stem cell, genetic material, or bioactive molecule delivery (Führmann and Shoichet, 2018). These biomaterials can have a natural or synthetic origin.…”

Section: Introductionmentioning

confidence: 99%

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Ojeda-Hernández

Canales-Aguirre

Matías‐Guiu

et al. 2020

Front. Bioeng. Biotechnol.

133

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It is well known that the central nervous system (CNS) has a limited regenerative capacity and that many therapeutic molecules cannot cross the blood brain barrier (BBB). The use of biomaterials has emerged as an alternative to overcome these limitations. For many years, biomedical applications of chitosan have been studied due to its remarkable biological properties, biocompatibility, and high versatility. Moreover, the interest in this biomaterial for CNS biomedical implementation has increased because of its ability to cross the BBB, mucoadhesiveness, and hydrogel formation capacity. Several chitosanbased biomaterials have been applied with promising results as drug, cell and gene delivery vehicles. Moreover, their capacity to form porous scaffolds and to bear cells and biomolecules has offered a way to achieve neural regeneration. Therefore, this review aims to bring together recent works that highlight the potential of chitosan and its derivatives as adequate biomaterials for applications directed toward the CNS. First, an overview of chitosan and its derivatives is provided with an emphasis on the properties that favor different applications. Second, a compilation of works that employ chitosan-based biomaterials for drug delivery, gene therapy, tissue engineering, and regenerative medicine in the CNS is presented. Finally, the most interesting trends and future perspectives of chitosan and its derivatives applications in the CNS are shown.

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The role of biomaterials in overcoming barriers to regeneration in the central nervous system

Cited by 11 publications

References 15 publications

Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine

Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine

Nose-to-Brain: The Next Step for Stem Cell and Biomaterial Therapy in Neurological Disorders

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

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