The role of bisphenol A in the carcinogenesis process

Chludzińska, Sylwia; Modzelewska, Patrycja; Koda, Mariusz; Lewko, Jolanta; Reszeć, Joanna

doi:10.5114/ms.2018.78689

Cited by 3 publications

(3 citation statements)

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“…BPA is used in many areas of industry, primarily to produce plastics such as polyacrylates, polyesters, polycarbonates, epoxy, and phenolic resins [ 6 ]. Polycarbonates are widely used due to their high durability in a wide temperature range (from −40 °C to +145 °C), hardness, resistance to acids, and transparency [ 7 ]. Both polycarbonates and epoxy resins are used in the manufacture of food storage packaging, e.g., beverage [ 8 ] bottles, baby bottles [ 9 ], and food storage containers [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…BPA has teratogenic, mutagenic, and carcinogenic effects, and can also interfere with the process of chromosome separation during meiosis. It can have a carcinogenic effect and increase susceptibility to cancer [ 7 ]. Extensive research over the past decade has shown a close relationship between BPA exposure and the occurrence of various cancers, especially breast and ovarian cancers.…”

Section: Introductionmentioning

confidence: 99%

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Can Antioxidants Reduce the Toxicity of Bisphenol?

2022

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BPA is still the subject of extensive research due to its widespread use, despite its significant toxicity resulting not only from its negative impact on the endocrine system but also from disrupting the organism’s oxidative homeostasis. At the molecular level, bisphenol A (BPA) causes an increased production of ROS and hence a change in the redox balance, mitochondrial dysfunction, and modulation of cell signaling pathways. Importantly, these changes accumulate in animals and humans, and BPA toxicity may be aggravated by poor diet, metabolic disorders, and coexisting diseases. Accordingly, approaches using antioxidants to counteract the negative effects of BPA are being considered. The preliminary results that are described in this paper are promising, however, it should be emphasized that further studies are required to determine the optimal dosage and treatment regimen to counteract BPA toxicity. It also seems necessary to have a more holistic approach showing, on the one hand, the influence of BPA on the overall human metabolism and, on the other hand, the influence of antioxidants in doses that are acceptable with the diet on BPA toxicity. This is due in part to the fact that in many cases, the positive effect of antioxidants in in vitro studies is not confirmed by clinical studies. For this reason, further research into the molecular mechanisms of BPA activity is also recommended.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Can Antioxidants Reduce the Toxicity of Bisphenol?

2022

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“…The substance also causes serious changes in the intestines, including modification of the permeability of the mucosa, inflammatory changes and disturbances in motility. Exposure to BPA may also result in a higher risk of neoplasm, hypertension and diabetes ( Han and Hong, 2016 ; Chludzińska et al, 2018 ; Farrugia et al, 2021 ; Khan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Influence of bisphenol A and its analog bisphenol S on cocaine- and amphetamine-regulated transcript peptide–positive enteric neurons in the mouse gastrointestinal tract

Makowska,

Fagundes,

Gonkowski

2023

Front. Mol. Neurosci.

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IntroductionBisphenol A (BPA) is used in large quantities for the production of plastics and is present in various everyday objects. It penetrates living organisms and shows multidirectional adverse influence on many internal organs. For this reason, BPA is often replaced in plastic production by other substances. One of them is bisphenol S (BPS), whose effects on the enteric nervous system (ENS) have not been explained.MethodsTherefore, the present study compares the influence of BPA and BPS on the number of enteric neurons immunoreactive to cocaine-and amphetamine-regulated transcript (CART) peptide located in the ENS of the stomach, jejunum and colon with the use of double immunofluorescence method.ResultsThe obtained results have shown that both bisphenols studied induced an increase in the number of CART-positive enteric neurons, and the severity of changes depended on the type of enteric ganglion, the dose of bisphenols and the segment of the digestive tract. The most visible changes were noted in the myenteric ganglia in the colon. Moreover, in the colon, the changes submitted by BPS are more noticeable than those observed after BPA administration. In the stomach and jejunum, bisphenol-induced changes were less visible, and changes caused by BPS were similar or less pronounced than those noted under the impact of BPA, depending on the segment of the gastrointestinal tract and ganglion type studied.DiscussionThe results show that BPS affects the enteric neurons containing CART in a similar way to BPA, and the BPS impact is even stronger in the colon. Therefore, BPS is not neutral for the gastrointestinal tract and ENS.

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Impacts of Environmental Pollution on Brain Tumorigenesis

Pagano

Navarra

Coppola

et al. 2023

IJMS

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Pollutants consist of several components, known as direct or indirect mutagens, that can be associated with the risk of tumorigenesis. The increased incidence of brain tumors, observed more frequently in industrialized countries, has generated a deeper interest in examining different pollutants that could be found in food, air, or water supply. These compounds, due to their chemical nature, alter the activity of biological molecules naturally found in the body. The bioaccumulation leads to harmful effects for humans, increasing the risk of the onset of several pathologies, including cancer. Environmental components often combine with other risk factors, such as the individual genetic component, which increases the chance of developing cancer. The objective of this review is to discuss the impact of environmental carcinogens on modulating the risk of brain tumorigenesis, focusing our attention on certain categories of pollutants and their sources.

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The role of bisphenol A in the carcinogenesis process

Cited by 3 publications

References 27 publications

Can Antioxidants Reduce the Toxicity of Bisphenol?

Can Antioxidants Reduce the Toxicity of Bisphenol?

Influence of bisphenol A and its analog bisphenol S on cocaine- and amphetamine-regulated transcript peptide–positive enteric neurons in the mouse gastrointestinal tract

Impacts of Environmental Pollution on Brain Tumorigenesis

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