The Role of Bone Scintigraphy in the Diagnosis of Rheumatoid Arthritis According to the 2010 ACR/EULAR Classification Criteria

Kim, Ji Young; Cho, Soo Kyung; Han, Minkyung; Choi, Yun Young; Bae, Sang Cheol; Sung, Yoon Kyoung

doi:10.3346/jkms.2014.29.2.204

Cited by 16 publications

(21 citation statements)

References 16 publications

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“…Patients of the Department of Orthopedics of the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, who had clinically confirmed RA (as per ACR/EULAR criteria [13]) during at least the past 3 months [3]) from February 3, 2017 to January 1, 2018 were included in this study. Patients aged 18 years and older were included in this study.…”

Section: Methodsmentioning

confidence: 99%

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Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial

Yin

et al. 2018

Med Sci Monit

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BackgroundCalcitriol (1 alpha, 25-dihydroxy vitamin D3) is a good vitamin D supplement but can cause hypercalcemia. Whereas, 22-oxa-1 alpha, 25-dihydroxy vitamin D3 (22-oxa-calcitriol) has less hypercalcemic activity than calcitriol and is reported to be effective for cell-proliferative diseases. The objective of the study was to compare renal function and blood tests of arthritis patients receiving calcitriol supplements with those receiving 22-oxa-calcitriol supplements.Material/MethodsA total of 369 patients with clinically confirmed rheumatoid arthritis were included in this phase II trial. Patients received lactose powder (the placebo group, n=123), 50 000 IU/week of 22-oxa-calcitriol (the treatment group, n=123), or 50 000 IU/week of calcitriol (the control group, n=123) for 6 weeks. At the time of enrollment and after 6 weeks of supplementation, renal function tests, blood tests, and secondary outcome measures were evaluated. One-way ANOVA and the chi-squared test for independence were performed for continuous data and constant data at a 95% of confidence level.ResultsBoth 22-oxa-calcitriol and calcitriol successfully decreased swollen joints in patients with rheumatoid arthritis, and both improved Health Assessment Questionnaire Disease Activity Index scores and serum vitamin D levels. The intensity of improvement of serum vitamin D levels in both groups was the same (P<0.0001, q=0.24); however, calcitriol caused hypercalcemia (P<0.0001, q=12.59).ConclusionsThis study found that 22-oxa-calcitriol was a good option for vitamin D supplementation in rheumatoid arthritis patients.

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Section: Methodsmentioning

confidence: 99%

“…Patients aged 18 years and older were included in this study. Active RA was defined as at least 4 swollen joints (out of 70 examined) [13]. Patients who had erosions in radiographic images, morning stiffness (at least half an hour in duration) were included in this study.…”

Section: Methodsmentioning

confidence: 99%

Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial

Yin

et al. 2018

Med Sci Monit

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“…Several studies reported that bone scintigraphy did not discriminate active inflammatory joint from inactive joint in RA patients [ 61 62 ] and was inferior to ultrasonography to detect early RA [ 63 ]. However, recent study showed that TPBS had better diagnostic performance than conventional bone scintigraphy and was helpful in the diagnosis of RA in patients with insufficient evidence of RA [ 64 65 ].…”

Section: Main Bodymentioning

confidence: 99%

Bone scintigraphy in patients with pain

Shin

Kim

2017

Korean J Pain

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Nuclear medicine imaging is widely used in pain medicine. Low back pain is commonly encountered by physicians, with its prevalence from 49% to 70%. Computed tomography (CT) or magnetic resonance imaging (MRI) are usually used to evaluate the cause of low back pain, however, these findings from these scans could also be observed in asymptomatic patients. Bone scintigraphy has an additional value in patients with low back pain. Complex regional pain syndrome (CRPS) is defined as a painful disorder of the extremities, which is characterized by sensory, autonomic, vasomotor, and trophic disturbances. To assist the diagnosis of CRPS, three-phase bone scintigraphy is thought to be superior compared to other modalities, and could be used to rule out CRPS due to its high specificity. Studies regarding the effect of bone scintigraphy in patients with extremity pain have not been widely conducted. Ultrasound, CT and MRI are widely used imaging modalities for evaluating extremity pain. However, SPECT/CT has an additional role in assessing pain in the extremities.

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“…Conventional radiography [Ostergaard et al, ] and ultrasound [Szkudlarek et al, ; Scheel et al, ; Balint et al, ] imaging techniques continue to be widely used for detection and clinical assessment of RA as they are readily available, fast, and inexpensive [Brown, ]. Magnetic resonance imaging (MRI) [Borrero et al, ] and bone scan [Kim et al, ] are also used for detection of RA as they help identify regions with higher concentrations of white blood cells and metabolic activity compared with the healthy sites. These diagnostic techniques are invasive/active imaging modalities that require injecting contrast agents or exposure to ionizing radiation, and are generally located in specialty radiologic imaging facilities.…”

Section: Introductionmentioning

confidence: 99%

Pre‐Clinical Testing of Microwave Radiometer and a Pilot Study on the Screening Inflammation of Knee Joints

Ravi

Sharma

Arunachalam

2019

Bioelectromagnetics

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This article presents the pre‐clinical evaluation of our custom‐built, single‐band microwave radiometer centered at 1.3 GHz for deep tissue thermometry, and a pilot study on volunteers for passive detection of inflammation in knee joints. The electromagnetic (EM) compatibility of the battery‐operated radiometer for clinical use was assessed as per International Special Committee on Radio Interference (CISPR) 22 standard. The ability to detect inflammation in knee joints was assessed using a substrate integrated waveguide antenna connected to the radiometer. EM compatibility tests carried out in the laboratory indicated device immunity to intentional radiated interference up to −20 dBm injected power in the global system for mobile communication frequency band, and pre‐compliance to CISPR 22 standard. Radiometer temperature measurements recorded at the lateral and medial aspects of both knees of 41 volunteers indicated mean temperature greater than 33°C for the diseased sites compared with the mean temperature of 28°C measured for the healthy sites. One‐way analysis of variance statistics indicated significantly (P < 0.005) higher radiometer temperature at the diseased sites unlike the healthy sites. Thus, the EM pre‐compliance of the device and the potential to measure deep tissue inflammation were demonstrated. Bioelectromagnetics. 2019;40:402–411. © 2019 Bioelectromagnetics Society.

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The Role of Bone Scintigraphy in the Diagnosis of Rheumatoid Arthritis According to the 2010 ACR/EULAR Classification Criteria

Cited by 16 publications

References 16 publications

Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial

Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial

Bone scintigraphy in patients with pain

Pre‐Clinical Testing of Microwave Radiometer and a Pilot Study on the Screening Inflammation of Knee Joints

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