The role of calcium gluconate in electrochemical activation of titanium for biomimetic coating of calcium phosphate

Shibli, S.M.A.; Mathai, Suja

doi:10.1002/jbm.a.31809

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Thus, much effort has been devoted to apply bioactive and osteoconductive nano HA materials as coatings on implant materials for orthopedic applications (Webster et al 2002;Choi et al 2004;Bigi et al 2005;Sato et al 2005Sato et al , 2006Sato et al , 2007Balasundaram et al 2006;Evis et al 2006;Narayanan et al 2008;Teng et al 2008;Ciobanu et al 2007;Shibli and Mathai 2008). For instance, recently it has been reported that enhanced cell functions were observed on titanium coated with nano HA by an electrochemical method (Narayanan et al 2008).…”

Section: Osteoblast Adhesionmentioning

confidence: 99%

Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants

Zhang

Chen²,

Rodríguez³

et al. 2008

IJN

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Natural bone consists of hard nanostructured hydroxyapatite (HA) in a nanostructured protein-based soft hydrogel template (ie, mostly collagen). For this reason, nanostructured HA has been an intriguing coating material on traditionally used titanium for improving orthopedic applications. In addition, helical rosette nanotubes (HRNs), newly developed materials which form through the self-assembly process of DNA base pair building blocks in body solutions, are soft nanotubes with a helical architecture that mimics natural collagen. Thus, the objective of this in vitro study was for the fi rst time to combine the promising attributes of HRNs and nanocrystalline HA on titanium and assess osteoblast (bone-forming cell) functions. Different sizes of nanocrystalline HA were synthesized in this study through a wet chemical precipitation process following either hydrothermal treatment or sintering. Transmission electron microscopy images showed that HRNs aligned with nanocrystalline HA, which indicates a high affi nity between both components. Some of the nanocrystalline HA formed dense coatings with HRNs on titanium. More importantly, results demonstrated enhanced osteoblast adhesion on the HRN/ nanocrystalline HA-coated titanium compared with conventional uncoated titanium. Among all the HRN/nanocrystalline HA coatings tested, osteoblast adhesion was the greatest when HA nanometer particle size was the smallest. In this manner, this study demonstrated for the fi rst time that biomimetic HRN/nanocrystalline HA coatings on titanium were cytocompatible for osteoblasts and, thus, should be further studied for improving orthopedic implants.

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Section: Osteoblast Adhesionmentioning

confidence: 99%

Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants

Zhang

Chen²,

Rodríguez³

et al. 2008

IJN

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“…Moreover, this method ensures the sol's homogeneity, the possibility to regulate polycondensate molecules, a large number of metalorganic and inorganic metal salt compounds, used as precursors, as well as the possibility to obtain multiingredient coatings of high purity on different bases. 7,8 Another important factor affecting the final quality of the products that come into contact with blood is the proper resistance of the modified surface to medical sterilisation. Presently, cardiovascular implants are usually sterilised with ethylene oxide (EO) and with pressurisedwater steam in an autoclave.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties of a Ti67 alloy after EO and steam sterilization

Walke¹,

Basiaga²,

Paszenda³

et al. 2016

Mater. Tehnol.

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The techniques of surface modification play a significant role in forming the physical and chemical properties of titanium and its alloys. Among many techniques for the layers' application, chemical and electrochemical methods are particularly interesting, as they make it possible to control the process of depositing thin layers of the material and modifying their properties through a change of reagents and the parameters of the deposition process. A special advantage the methods bring is the possibility to obtain layers that offer a perfect coating for geometrically complex surfaces. Apart from improved haemocompatibility, a significant issue related to the creation of the layers is also a proper set of physicochemical properties. Therefore, the study comprised tests of the physicochemical properties of oxide layers deposited on the surface of samples taken from a Ti-6Al-7Nb alloy. The samples were subject to various surface modifications, i.e., grinding, electrolytic polishing, a SiO2 layer was applied using the sol-gel method and TiO2 by means of an anodic oxide and medical sterilisation methods (EO and steam). The corrosion-resistance tests were performed on the basis of registered anodic polarisation curves and the Stern method. Electrochemical Impedance Spectroscopy (EIS) was also used in order to evaluate the phenomena taking place on the surface of the tested alloys. As a part of the evaluation of the mechanical properties of surface layers created in such a way, hardness tests and tests of the adhesion of those layers to a metallic substrate were made. Measurements of the instrumental hardness were made with the Oliver & Pharr method, whereas the adhesion of the layers to the substrate was measured by means of a scratch test. The suggestion of proper surface treatment variants has perspective significance and will help to develop the technological conditions with specified parameters of the oxide coating's creation on the surface of metallic implants. Keywords: Ti-6Al-7Nb (Ti67) alloy, sol-gel, anodic oxide, scratch-test, nanohardness, EIS, potentiodynamic method Tehnike modifikacije povr{ine igrajo pomembno vlogo pri doseganju fizikalnih in kemijskih lastnosti titana in njegovih zlitin. Med mnogimi tehnikami uporabe tankih plasti so {e posebej zanimive kemijske in elektrokemijske metode, ker omogo~ajo kontrolo postopka depozicije tanke plasti materiala in spreminjanje njihovih lastnosti, z zamenjavo reagentov in parametrov procesa depozicije. Posebna prednost, ki jo omogo~ajo metode, je mo`nost izdelave plasti, ki omogo~ajo popolno prevleko pri geometrijsko kompleksnih povr{inah. Poleg izbolj{ane hemokompatibilnosti je pomembno vpra{anje povezano z nastankom plasti in tudi z doseganjem ustreznih fizikalno kemijskih lastnosti. Zato je {tudija obsegala preizkuse fizikalno kemijskih lastnosti oksidnih plasti, po depoziciji na povr{ini vzorcev iz Ti-6Al-7Nb zlitine. Na vzorcih so bile opravljene razli~ne modifikacije povr{ine: bru{enje, elektrolitsko poliranje, SiO2 plast, izdelana po sol-gel postopku in T...

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“…Many researches have been dedicated to preparing Ti/ HA composite materials in a biomimetic route recently. The so called biomimetic coating technique is to induce the deposition of apatite in simulated body fluid (SBF), 5 with ion concentrations nearly equal to those of human extracellular fluid. It is apparent that this method can be readily adapted to synthesising Ti/HA composite materials since it does not require complex equipment, the objects to be coated can be large or irregularly shaped.…”

Section: Introductionmentioning

confidence: 99%

The biomimetic deposition of carbonate apatite induced by titanium base calcium enriched silica films

Xiao

Liu

Gao

2011

Materials Science and Technology

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In order to obtain a fast biomimetic coating on titanium substrates, calcium enriched silica films were prepared on pure titanium substrates by sol–gel method under the following conditions: pH = 3 and the molar ratio of tetraethyl orthosilicate (TEOS)/H2O/EtOH/Ca2+ = 1∶4∶11∶0·08. The titanium base calcium enriched silica film is soaked in a slightly supersaturated Ca/P solution, with the concentration of calcium ion and phosphate group being 1·5 times of that of simulated body fluid, for seven days, a uniform apatite layer is precipitated onto the surfaces of calcium enriched silica films, which is quite rapidly. The investigation adopted SEM, EDX, Fourier transform infrared spectroscope and XRD to indicate that the coating was carbonate hydroxyapatite. The results show that it is a feasible way to obtain carbonate hydroxyapatite through functionalising the pure titanium substrates by preparing calcium enriched silica films on it from a sol–gel method.

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The role of calcium gluconate in electrochemical activation of titanium for biomimetic coating of calcium phosphate

Cited by 7 publications

References 34 publications

Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants

Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants

Physicochemical properties of a Ti67 alloy after EO and steam sterilization

The biomimetic deposition of carbonate apatite induced by titanium base calcium enriched silica films

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