The Role of CD4+ Resident Memory T Cells in Local Immunity in the Mucosal Tissue – Protection Versus Pathology –

Hirahara, Kiyoshi; Kokubo, Kota; Aoki, Ami; Kiuchi, Masahiro; Nakayama, Toshinori

doi:10.3389/fimmu.2021.616309

Cited by 34 publications

(26 citation statements)

References 97 publications

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“…Recent studies have pointed out that the TME plays a key role in cancer proliferation, invasion, and metastasis and helps predict the prognosis of the disease ( Wang et al, 2021 ). CD4 + MTCs in the microenvironment can make a rapid and direct immune response to protect the host against the invasion of cancer cells ( Hirahara et al, 2021 ). These findings suggest that it is a potential therapeutic target ( Quail and Joyce, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of hub genes related to CD4+ memory T cell infiltration with gene co-expression network predicts prognosis and immunotherapy effect in colon adenocarcinoma

Tang

Yu²,

Zhang³

et al. 2022

Front. Genet.

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Background: CD4+ memory T cells (CD4+ MTCs), as an important part of the microenvironment affecting tumorigenesis and progression, have rarely been systematically analyzed. Our purpose was to comprehensively analyze the effect of CD4+ MTC infiltration on the prognosis of colon adenocarcinoma (COAD).Methods: Based on RNA-Seq data, weighted gene co-expression network analysis (WGCNA) was used to screen the CD4+ MTC infiltration genes most associated with colon cancer and then identify hub genes and construct a prognostic model using the least absolute shrinkage and selection operator algorithm (LASSO). Finally, survival analysis, immune efficacy analysis, and drug sensitivity analysis were performed to evaluate the role of the prognostic model in COAD.Results: We identified 929 differentially expressed genes (DEGs) associated with CD4+ MTCs and constructed a prognosis model based on five hub genes (F2RL2, TGFB2, DTNA, S1PR5, and MPP2) to predict overall survival (OS) in COAD. Kaplan–Meier analysis showed poor prognosis in the high-risk group, and the analysis of the hub gene showed that overexpression of TGFB2, DTNA, S1PR5, or MPP2 was associated with poor prognosis. Clinical prediction nomograms combining CD4+ MTC-related DEGs and clinical features were constructed to accurately predict OS and had high clinical application value. Immune efficacy and drug sensitivity analysis provide new insights for individualized treatment.Conclusion: We constructed a prognostic risk model to predict OS in COAD and analyzed the effects of risk score on immunotherapy efficacy or drug sensitivity. These studies have important clinical significance for individualized targeted therapy and prognosis.

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Section: Discussionmentioning

confidence: 99%

Identification of hub genes related to CD4+ memory T cell infiltration with gene co-expression network predicts prognosis and immunotherapy effect in colon adenocarcinoma

Tang

Yu²,

Zhang³

et al. 2022

Front. Genet.

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“…In addition, in the lungs of mice, CD4 + T RM cells that were induced by repeated exposure to Aspergillus fumigatus caused an inflammatory response ( 13 ). Thus, Th2 T RM cells play an important role in type 2 inflammatory responses in local tissues ( 81 ) ( Figure 2 ).…”

Section: Th2 Cells In the Induction Of Inflammationmentioning

confidence: 99%

Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis

et al. 2022

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Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, to trigger inflammatory responses. Emerging evidence reveals that Th2 cells also contribute to the repair of injured tissues after inflammatory reactions. However, when the tissue repair process becomes chronic, excessive, or uncontrolled, pathological fibrosis is induced, leading to organ failure and death. Thus, proper control of Th2 cells is needed for complete tissue repair without the induction of fibrosis. Recently, the existence of pathogenic Th2 (Tpath2) cells has been revealed. Tpath2 cells produce large amounts of Th2 cytokines and induce type 2 inflammation when activated by antigen exposure or tissue injury. In recent studies, Tpath2 cells are suggested to play a central role in the induction of type 2 inflammation whereas the role of Tpath2 cells in tissue repair and fibrosis has been less reported in comparison to conventional Th2 cells. In this review, we discuss the roles of conventional Th2 cells and pathogenic Th2 cells in the sequence of tissue inflammation, repair, and fibrosis.

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“…A key feature of Trm cells is their ability to be retained in barrier tissues for prolonged periods of time and their rapid response when encountering the same antigen ( 73 ). Trm cells are characterized by the expression of C-type lectin CD69 and integrin CD103 ( 74 ). In our mouse model of LVV, approximately 10% of the CD4 + T cells infiltrating the vascular tissue expressed CD103.…”

Section: Vasculitogenic T Cells In Gcamentioning

confidence: 99%

Vasculitogenic T Cells in Large Vessel Vasculitis

Watanabe¹,

Hashimoto²

2022

Front. Immunol.

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Vasculitis is an autoimmune disease of unknown etiology that causes inflammation of the blood vessels. Large vessel vasculitis is classified as either giant cell arteritis (GCA), which occurs exclusively in the elderly, or Takayasu arteritis (TAK), which mainly affects young women. Various cell types are involved in the pathogenesis of large vessel vasculitis. Among these, dendritic cells located between the adventitia and the media initiate the inflammatory cascade as antigen-presenting cells, followed by activation of macrophages and T cells contributing to vessel wall destruction. In both diseases, naive CD4+ T cells are polarized to differentiate into Th1 or Th17 cells, whereas differentiation into regulatory T cells, which suppress vascular inflammation, is inhibited. Skewed T cell differentiation is the result of aberrant intracellular signaling, such as the mechanistic target of rapamycin (mTOR) or the Janus kinase signal transducer and activator of transcription (JAK-STAT) pathways. It has also become clear that tissue niches in the vasculature fuel activated T cells and maintain tissue-resident memory T cells. In this review, we outline the most recent understanding of the pathophysiology of large vessel vasculitis. Then, we provide a summary of skewed T cell differentiation in the vasculature and peripheral blood. Finally, new therapeutic strategies for correcting skewed T cell differentiation as well as aberrant intracellular signaling are discussed.

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The Role of CD4+ Resident Memory T Cells in Local Immunity in the Mucosal Tissue – Protection Versus Pathology –

Cited by 34 publications

References 97 publications

Identification of hub genes related to CD4+ memory T cell infiltration with gene co-expression network predicts prognosis and immunotherapy effect in colon adenocarcinoma

Identification of hub genes related to CD4+ memory T cell infiltration with gene co-expression network predicts prognosis and immunotherapy effect in colon adenocarcinoma

Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis

Vasculitogenic T Cells in Large Vessel Vasculitis

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