The role of Cdc14 phosphatases in the control of cell division

Clifford, Dawn M.; Chen, Chun-Ti; Roberts, Rachel H.; Feoktistova, Anna; Wolfe, Benjamin; Chen, Jun‐Song; McCollum, Dannel; Gould, Kathleen L.

doi:10.1042/bst0360436

Cited by 30 publications

(30 citation statements)

References 16 publications

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“…It has numerous roles in mitotic exit, as has been extensively reviewed Amon 2008;Clifford et al 2008;Queralt and Uhlmann 2008a;Mocciaro and Schiebel 2010;Meitinger et al 2012). One of its important functions is to promote the transition from APC Cdc20 to APC Cdh1 , by dephosphorylating CDK sites on Cdh1 that block its association with the APC/C (Visintin et al 1997;Zachariae et al 1998;Jaspersen et al 1999).…”

Section: The Apc/cmentioning

confidence: 99%

Mitotic Exit and Separation of Mother and Daughter Cells

2012

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Productive cell proliferation involves efficient and accurate splitting of the dividing cell into two separate entities. This orderly process reflects coordination of diverse cytological events by regulatory systems that drive the cell from mitosis into G1. In the budding yeast Saccharomyces cerevisiae, separation of mother and daughter cells involves coordinated actomyosin ring contraction and septum synthesis, followed by septum destruction. These events occur in precise and rapid sequence once chromosomes are segregated and are linked with spindle organization and mitotic progress by intricate cell cycle control machinery. Additionally, critical parts of the mother/daughter separation process are asymmetric, reflecting a form of fate specification that occurs in every cell division. This chapter describes central events of budding yeast cell separation, as well as the control pathways that integrate them and link them with the cell cycle.

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Section: The Apc/cmentioning

confidence: 99%

Mitotic Exit and Separation of Mother and Daughter Cells

2012

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“…Related mechanisms have been identified in budding yeast and humans, showing that they are conserved and so play a significant part in cell cycle controls in all eukaryotic organisms (Darieva et al, 2006;Fu et al, 2008). Cdc14p proteins form a class of phosphatases that have important and diverse roles in controlling cell cycle progression, through regulating a number of crucial target substrate proteins, to couple nuclear and cytoplasmic divisions (Simanis, 2003;Stegmeier and Amon, 2004;Vázquez-Novelle et al, 2005;Clemente-Blanco et al, 2006;Clifford et al, 2008a). In budding yeast, one function of Cdc14p is to control cell cycle-specific gene expression through regulating the nuclear localisation of transcription factors required for this process.…”

Section: Introductionmentioning

confidence: 99%

Regulation of cell cycle-specific gene expression in fission yeast by the Cdc14p-like phosphatase Clp1p

Papadopoulou

Chen

Mead

et al. 2010

Journal of Cell Science

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SummaryRegulated gene expression makes an important contribution to cell cycle control mechanisms. In fission yeast, a group of genes is coordinately expressed during a late stage of the cell cycle (M phase and cytokinesis) that is controlled by common cis-acting promoter motifs named pombe cell cycle boxes (PCBs), which are bound by a trans-acting transcription factor complex, PCB binding factor (PBF). PBF contains at least three transcription factors, a MADS box protein Mbx1p and two forkhead transcription factors, Sep1p and Fkh2p. Here we show that the fission yeast Cdc14p-like phosphatase Clp1p (Flp1p) controls M-G1 specific gene expression through PBF. Clp1p binds in vivo both to Mbx1p, a MADS box-like transcription factor, and to the promoters of genes transcribed at this cell cycle time. Because Clp1p dephosphorylates Mbx1p in vitro, and is required for Mbx1p cell cycle-specific dephosphorylation in vivo, our observations suggest that Clp1p controls cell cycle-specific gene expression through binding to and dephosphorylating Mbx1p.

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“…In Saccharomyces cerevisiae and Schizosaccharomyces pombe, these enzymes accomplish analogous functions during mitosis and cytokinesis (Stegmeier and Amon, 2004;Clifford et al, 2008;. In vertebrates, the situation is more complex since a duplication of the CDC14 gene occurred.…”

Section: Introductionmentioning

confidence: 99%

Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis

Clément

Solnica‐Krezel

Gould

2012

Developmental Dynamics

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Background: Cyclin-dependent kinases (Cdks) and their counteracting phosphatases are key regulators of cell cycle progression. In yeasts, the Cdc14 family of phosphatases promotes exit from mitosis and progression through cytokinesis by reversing phosphorylation of Cdk1 substrates. In vertebrates, CDC14 paralogs, CDC14A and CDC14B, have so far been implicated in processes ranging from DNA damage repair, meiosis, centrosome duplication to ciliogenesis. However, the question of whether CDC14 paralogs can functionally compensate for each other has yet to be addressed. Results: Here, using antisense morpholino oligonucleotides to inhibit Cdc14A1 function, we observed that Cdc14A1 depleted zebrafish embryos displayed ventrally curved body and left-right asymmetry defects, similar to Cdc14B deficient embryos and zebrafish mutants with cilia defects. Accordingly, we found that Cdc14A1, like Cdc14B, plays a role in ciliogenesis in the Kupffer's vesicle (KV) and other ciliated tissues, and can do so independently of its function in cell cycle. Furthermore, we observed reciprocal suppression of KV cilia length defects of Cdc14A1 and Cdc14B deficient embryos by cdc14b and cdc14a1 RNAs, respectively. Conclusions: Together, these studies demonstrate for the first time that Cdc14A and Cdc14B have overlapping functions in the ciliogenesis process during zebrafish development.

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The role of Cdc14 phosphatases in the control of cell division

Cited by 30 publications

References 16 publications

Mitotic Exit and Separation of Mother and Daughter Cells

Mitotic Exit and Separation of Mother and Daughter Cells

Regulation of cell cycle-specific gene expression in fission yeast by the Cdc14p-like phosphatase Clp1p

Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis

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