The role of children and adults as a reservoir of pathogens during the seasonal rise in the incidence of upper respiratory tract infections

Соломай, Т. В.; Семененко, Т А; Филатов, Н Н; Колбутова, К. Б.; Олейникова, Д. Ю.; Каражас, Н В

doi:10.22627/2072-8107-2020-19-3-5-11

Cited by 17 publications

(5 citation statements)

References 32 publications

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“…Около 90% случаев инфекционного мононуклеоза обусловлены ВЭБ. При этом отдельный статистический учет случаев заболеваний ВЭБ-инфекцией в Российской Федерации не ведется [21].…”

Section: ключевые моменты что известно о предмете исследования?unclassified

Possibilities of a biobank for serological monitoring of infectious morbidity

Svitich,

Zverev,

Solomay

et al. 2023

Cardiovasc Ther Prev

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Currently, monitoring infectious morbidity, control and forecasting the epidemic process is a topical health problem.Aim. To analyze the capabilities of the biobank for serological monitoring of infectious diseases using the Epstein- Barr virus (EBV), which is associated with infectious mononucleosis, as well as somatic pathology, including cancer.Material and methods. Using the quantitative enzyme- linked immunosorbent assay for specific antibodies to various EBV proteins, we studied blood serum samples from healthy individuals (2010, 2016, 2019, 2020, 2021 and 2022) from the collection of the N. F. Gamaleya National Center of Epidemiology and Microbiology.Results. For the first time, the intensity of EBV epidemic process among apparently healthy adult residents of the capital was assessed using samples of biological material and a biobank information database. At the time of examination, 0,8% of individuals were not infected with EBV, and 9,4% suffered reactivation of a chronic infection. There were no significant changes in detection rate of markers over the years.Conclusion. Certified collections of blood sera can be effectively used to study population immunity, the prevalence of individual infections, population protection nationwide, etc.

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Section: ключевые моменты что известно о предмете исследования?unclassified

Possibilities of a biobank for serological monitoring of infectious morbidity

Svitich,

Zverev,

Solomay

et al. 2023

Cardiovasc Ther Prev

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“…Подтверждением тому, что ВЭБинфекция как у детей, так и у взрослых может проходить под маской респираторного заболевания, являются ре зультаты исследования мазков из рото и носоглот ки у пациентов с инфекциями верхних дыхательных путей на наличие генетического материала ВЭБ, вирусов гриппа А и В, парагриппа, РСвирусов, метапневмовирусов, сезонных коронавирусов, риновирусов, бокавирусов, аденовирусов и бак терий Mycoplasma pneumoniae и Chlamydophila pneumoniae, в ходе которого установлено, что ВЭБ занял первое место по частоте выявления, которая составила 37,14% у взрослых и 33,72% -у детей [22].…”

Section: оригинальные статьи Original Articlesunclassified

“…Проведенные исследования показали, что включение определения ДНК ВЭБ в систему мо ниторинга возбудителей гриппа и ОРВИ позволя ет повысить этиологическую расшифровку и дать оценку циркуляции ВЭБ в период сезонного эпиде мического подъема ОРВИ [22].…”

Section: оригинальные статьи Original Articlesunclassified

“…Проведенное исследование показало, что инфицирование SARSCoV2 являет ся триггером репродукции ВЭБ в клетках хозяина, что, в свою очередь, определяет тяжесть клини ческих проявлений [24,48]. Не исключена реак тивация ВЭБ при инфицировании возбудителями гриппа и острых респираторных заболеваний [22].…”

Section: оригинальные статьи Original Articlesunclassified

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Scientific Substantiation of the Creation and Prospects for the Development of an Epidemiological Surveillance System for Infection Caused by the Epstein-Barr Virus

Solomay

Симонова

Semenenko

2022

Epidemiology and Vaccinal Prevention

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Relevance. At the present stage, the Russian Federation does not have a coherent system of supervision and control of infection caused by the Epstein-Barr virus (EBV), while there is an epidemiological problem with this pathology, requiring the development and adoption of a set of adequate management decisions. The goal is to scientifically substantiate the creation of an epidemiological surveillance system (ES) for EBV -infection in Russia. Materials and methods. Based on the results of previous studies, an assessment of the manifestations of the epidemic process of EBV infection and measures aimed at each of its links was carried out. Results. The structure and content of the system of epidemiological surveillance of EBV infection are presented. Conclusion. To implement and improve the effectiveness of EBV-infection control, it is necessary to adjust existing and develop new regulatory and methodological documents that allow introducing: a standard definition of the case of EBV-infection and new approaches to accounting and registration; studies of nasopharyngeal smear material for the presence of EBV genetic material as part of the monitoring of influenza and ARVI pathogens; algorithms for the examination of patients with diagnoses that do not exclude the presence of active EBV-infection, as well as organ, tissue and cell donors with the determination of a complex of nonspecific immunological markers (neopterin, melatonin, C-reactive protein, ALT); standard operating procedures for medical professionals for the identification and isolation of patients with active EBV-infection, clinical and laboratory diagnostics, registration and accounting, the use of personal protective equipment and nonspecific immunoprophylaxis. Also, improving the control of EBVinfection is impossible without continuing scientific research; professional training of medical workers on the clinic, diagnosis, epidemiology and prevention of EBV-infection; development of modern visual methods and means of informing the population about the clinic and prevention of EBV-infection.

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“…Неухильне зростання кількості захворювань, спричинених ВЕБ як серед дорослих, так і дітей, що пов'язане з його специфічною тропністю до імунокомпетентних клітин, довічною персистенцією і латентним перебігом обумовлює необхідність всебічного вивчення і розробки ефективних методів лікування [3,4,5]. Удосконалення методів лабораторної діагностики ВЕБ-інфекції призвело до істинного збільшення рівня захворюваності [4,6].…”

Section: вступunclassified

Prediction of the course and consequences of infectious mononucleosis caused by the Epstein-Barr virus

Pavlikova

2021

Actual Problems of Modern Medicine

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Abstract. The study of the role of Epstein-Barr viral infection in the occurrence of various pathological conditions in humans is of great importance. This is due to the significant epidemiological role, since upon reaching the age of majority, more than 90% of people are infected of Epstein-Barr virus. The steady increase in the number of diseases caused by Epstein-Barr virus both among adults and children, which is associated with its specific tropism for immunocompetent cells, lifelong persistence and latent course necessitates a comprehensive study and development of effective treatment methods. Purpose of the work: to assess clinical and immunological parameters in order to identify a protracted course and predict unfavorable outcomes in patients with infectious mononucleosis caused by the Epstein-Barr virus. Materials and methods: To achieve this purpose, 60 patients with infectious mononucleosis were examined, among them 38 women (63.3%), 22 men (36.7%). The average age of the patients was 24.3±4.3 years. The material for the study was the patient's serum obtained in the dynamics of the disease. The complex of examination of patients with Infectious mononucleosis included clinical and biochemical methods, enzyme-linked immunosorbent assay, polymerase chain reaction method, immunogram. The research results were processed by the method of variation and correlation statistics using the Statistica 10.0 for Windows program. Results. The analysis of the obtained results made it possible to establish that in patients with infectious mononucleosis, changes were revealed in the system of cellular and humoral immunity and its multidirectionality. The progressive nature of changes in immune parameters indicates the formation of a secondary cellular immune imbalance, activation of the humoral link, a change in the balance of immunoregulatory mediators towards Th2 cells. In the acute period, statistically significant violations of the cellular link of immunity were established, which were characterized by an increase in the number of cells with killer activity: mature T-lymphocytes (CD3+), cytotoxic T-suppressor cells (CD8+), cells expressing the activation marker CD25+ (IL-2 receptor ) and increased Th1/Th2. Conclusions. Thus, changes in the cellular and humoral links of immunity in a favorable course of myocardial infarction are characterized by activation of the cellular and humoral links of immunity, which is manifested by an increase in the content of lymphocytes in the peripheral blood with the [CD3+; CD4+; CD8+; CD16+; CD20+], Th1 cells, IgA and IgM; (p<0.05) with a tendency to normalization during the period of convalescence. With the formation of chronic forms of Epstein-Barr viral infection, a progressive nature of changes in immune parameters is noted, which indicates the formation of a secondary lymphocytic cellular imbalance, activation of the humoral link, a change in the balance of immunoregulatory mediators towards Th2 (a decrease in the content of [CD3+; CD4+; CD8+; CD16+]; an increase in the content of CD20+; IgG levels; Th2 (IL-4+) Th1/Th2 (p<0.05) due to an increase in the relative content of Th2 cells.

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The role of children and adults as a reservoir of pathogens during the seasonal rise in the incidence of upper respiratory tract infections

Cited by 17 publications

References 32 publications

Possibilities of a biobank for serological monitoring of infectious morbidity

Possibilities of a biobank for serological monitoring of infectious morbidity

Scientific Substantiation of the Creation and Prospects for the Development of an Epidemiological Surveillance System for Infection Caused by the Epstein-Barr Virus

Prediction of the course and consequences of infectious mononucleosis caused by the Epstein-Barr virus

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