The role of chromium supplementation in cardiovascular risk factors: A comprehensive reviews of putative molecular mechanisms

Gossa Al-Saadde, Dhiaa lattef; Haider, Ali Murtaza; Ali, Arsalan; Abdu Musad Saleh, Ebraheem; Turki Jalil, Abduladheem; Abdulelah, Furqan M.; Romero-Parra, Rosario Mireya; Tayyib, Nahla A.; Ramírez-Coronel, Andrés Alexis; Alkhayyat, Ameer S.

doi:10.1016/j.heliyon.2023.e19826

Cited by 9 publications

(5 citation statements)

References 104 publications

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“…98 Several epidemiological findings have confirmed that Cr (III) supplementation helps to improve CVD. 94,[99][100][101] Overall, the results of several studies have shown the positive role of Cr (III) supplementation in carbohydrate and lipid metabolism, 102 blood pressure changes, 103 the levels of oxidative stress markers, 104 and inflammatory indices. 101 However, Cr (VI) exerts opposing effects to those of Cr (III) and can induce oxidative stress, chronic inflammation, endothelial dysfunction, cell death, genetic development, and instability.…”

Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 99%

“…Individuals suffering from CVD have shown lower plasma Cr (III) levels compared with healthy subjects. 94 Cr (III) has also been reported to regulate blood pressure, 95 improve the blood lipid profile, 96 and act as an anti-inflammatory and antioxidative agent, which inhibits both NF-κB activation and proinflammatory and cytokine inflammatory mediator generation and enhances antioxidant enzyme activity. 94,95 Naturally occurring chromium is usually present as trivalent Cr (III) whereas hexavalent Cr (VI) in the environment is almost totally derived from human activities.…”

Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 99%

“…94 Cr (III) has also been reported to regulate blood pressure, 95 improve the blood lipid profile, 96 and act as an anti-inflammatory and antioxidative agent, which inhibits both NF-κB activation and proinflammatory and cytokine inflammatory mediator generation and enhances antioxidant enzyme activity. 94,95 Naturally occurring chromium is usually present as trivalent Cr (III) whereas hexavalent Cr (VI) in the environment is almost totally derived from human activities. While the general population is mainly exposed to trivalent chromium Cr (III) through food and dietary supplements 97 those at risk from Cr (VI) are primarily those involved in industrial processes such as galvanizing, painting, leather manufacture, steel production, and corrosion prevention.…”

Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 99%

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Heavy Metal Exposure and Cardiovascular Disease

Pan,

Gong,

Liang

2024

Circulation Research

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Heavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of reactive oxygen species, which can then exacerbate reactive oxygen species generation and induce inflammation, resulting in endothelial dysfunction, lipid metabolism distribution, disruption of ion homeostasis, and epigenetic changes. Over time, heavy metal exposure eventually results in an increased risk of hypertension, arrhythmia, and atherosclerosis. Strengthening public health prevention and the application of chelation or antioxidants, such as vitamins and beta-carotene, along with minerals, such as selenium and zinc, can diminish the burden of cardiovascular disease attributable to metal exposure.

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Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 99%

Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 99%

Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 99%

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Heavy Metal Exposure and Cardiovascular Disease

Pan,

Gong,

Liang

2024

Circulation Research

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“…Furthermore, the role of selenoproteins in the regulation of cellular functions and of Zn in the insulin-signaling pathway and clearance were mentioned in the literature as important mechanisms that could help to explain the effects of supplementation with these minerals on glucose metabolism [99,126]. On the other hand, Cr is known to enhance the transport of glucose into cells through the trafficking of glucose transporter type 4 (GLUT-4) [127], whereas vitamins B9 and B12 normalize homocysteine levels and in this way contribute to the maintenance of insulin sensitivity [104].…”

Section: Effects Of Micronutrient Supplementation On Glucose Homeostasismentioning

confidence: 99%

The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

Rudzka,

Kapusniak,

Zielińska

et al. 2024

Applied Sciences

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Micronutrient deficiencies co-occur with obesity throughout the world. While many factors may contribute to this, microbiota dysbiosis is certainly one that has received a lot of attention in recent years. This work aimed to review the current state of knowledge on the role of micronutrients in obesity and the effects of interventions in microbiota on the micronutrient status of humans. Gathered evidence suggested that the supplementation of most of the deficient micronutrients for people with excess weight may have a considerable, positive impact on lipid and glucose homeostasis and a small effect on weight loss. Interestingly, the doses of micronutrient supplementation that allowed for achieving the best results for most of the minerals and vitamins exceeded the tolerable upper intake levels. To avoid negative effects associated with an overdose of vitamins and minerals, applying microbiota interventions could be considered. Pro- and prebiotics were shown to improve the micronutrient status of humans, and several publications indicated that when applied together with vitamins and minerals, they could give greater benefits than each of these treatments alone. Therefore, supplementation with vitamins, minerals, and pro/pre/synbiotics in obesity treatment plans may be recommended; however, further research is required to mitigate risks and optimize the effects achieved.

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“…Chromium picolinate (CP) is a kind of organic chromium with good stability. CP has the effects of lowering blood glucose, alleviating oxidative stress, lowering blood lipids, improving cardiovascular diseases, and promoting weight loss [ 16 , 17 , 18 , 19 , 20 ]. As it has good hypoglycemic effects, it is clinically used for diabetes treatment.…”

Section: Introductionmentioning

confidence: 99%

Chromium Picolinate Regulates Bone Metabolism and Prevents Bone Loss in Diabetic Rats

Zheng,

Yan,

Shao

et al. 2024

Molecules

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Diabetic osteoporosis (DOP) is an abnormal metabolic disease caused by long-term hyperglycemia. In this study, a model rat of streptozotocin (STZ)-induced diabetes was established, and chromium picolinate (5 mg·kg−1) was given; the changes in blood glucose and body weight were detected before and after administration; and bone mineral density (BMD), bone morphology, bone turnover markers, inflammatory cytokines, and oxidative stress indicators were observed in each group. We found that after chromium picolinate (CP) intervention for 8 weeks, the blood glucose level was decreased; the BMD, the bone histomorphology parameters, and the pathological structure were improved; the expression of bone resorption-related proteins was downregulated; and the expression of bone formation-related proteins was upregulated. Meanwhile, serum antioxidant activity was increased, and inflammatory cytokine levels were decreased. In conclusion, CP could alleviate DOP by anti-oxidation, inhibition of bone turnover, anti-inflammation, and regulation of the OPG/RANKL/RANK signaling pathway. Therefore, CP has important application values for further development as a functional food or active medicine in DOP treatment.

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The role of chromium supplementation in cardiovascular risk factors: A comprehensive reviews of putative molecular mechanisms

Cited by 9 publications

References 104 publications

Heavy Metal Exposure and Cardiovascular Disease

Heavy Metal Exposure and Cardiovascular Disease

The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

Chromium Picolinate Regulates Bone Metabolism and Prevents Bone Loss in Diabetic Rats

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