The role of circadian rhythm in choroid plexus functions

Quintela, Telma; Furtado, André; Duarte, Ana Catarina; Gonçalves, Isabel; Myung, Jihwan; Santos, Cecília R. A.

doi:10.1016/j.pneurobio.2021.102129

Cited by 26 publications

(23 citation statements)

References 139 publications

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“…To exclude the impact of the circadian rhythm changes in choroid on the test results, all examinations were performed between 8:00 and 16:00. 7 AL measurement was performed using Lenstar LS900 non-contact biometrics. The patient was in a sitting position with the mandible on the jaw rack.…”

Section: Methodsmentioning

confidence: 99%

The relationship between choroidal thickness and axis length and corneal curvature in high myopia

Guan²,

Wei³

et al. 2022

Pak J Med Sci

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Objectives: To measure choroidal thickness (CT) in highly myopia eyes using enhanced depth imaging spectral-domain optical tomography (EDI SD-OCT) and explore the relationship between the CT and axial length (AL) and corneal curvature. Methods: This study assessed 66 eyes of 33 patients with both eyes of high myopia (equivalent sphericity ≥-6D or AL≥26mm) who underwent treatment at the department of ophthalmology, fourth hospital of Hebei Medical University from August 2020 to August 2021(High-myopia group). The control group included 54 eyes from 27 healthy volunteers. The patients in the two groups were 18~40 years old. EDI SD-OCT was used to measure the CT of subfoveal choroidal thickness (SFCT) and CT from fovea to nasal and temporal sides at an interval of 500~2500μm. The intraocular pressure, diopter, ocular axis, corneal curvature, and CT were compared between the two groups. The correlation between CT, diopter and AL was measured by Pearson’s r. Results: The diopter, AL, vertical corneal curvature, and CT in the high-myopia group were significantly higher than those in the control group (P<0.05). There was significant correlation between SFCT and AL in both groups (P<0.05). There was a negative correlation between AL and CT in high-myopia group (r=-0.395, P<0.05), and a positive correlation between AL and CT in control group (r=0.29, P<0.05). There was a weak correlation between AL and gender, intraocular pressure, and horizontal corneal curvature(P<0.05), and a negative correlation between AL and diopter (r=-0.861, P<0.001). Conclusion: EDI SD-OCT can quantitatively measure the CT of high myopia. The CT of patients with high myopia was significantly thinner than that of the control group of the same age. There was a significant correlation between diopter, AL and CT, suggesting that AL is a parameter indicating the degree of myopia, and the change of CT may play a role in the occurrence and development of high myopia. doi: https://doi.org/10.12669/pjms.38.7.6409 How to cite this:Lu H, Guan Y, Wei G, Li N. The relationship between choroidal thickness and axis length and corneal curvature in high myopia. Pak J Med Sci. 2022;38(7):1999-2004. doi: https://doi.org/10.12669/pjms.38.7.6409 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Methodsmentioning

confidence: 99%

The relationship between choroidal thickness and axis length and corneal curvature in high myopia

Guan²,

Wei³

et al. 2022

Pak J Med Sci

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“…Expression of critical clock genes and their products has been detected in the cells of the choroid plexus, which have a circadian oscillator modulated by estrogens (Quintela et al, 2013(Quintela et al, , 2018Yamaguchi et al, 2020) and in explants of choroid plexus maintained in vitro, including from the 4V, the circadian rhythmicity remained and even exceeded that of the suprachiasmatic nucleus (Myung et al, 2018). Thus, the choroid plexus seems to affect the master clock in the suprachiasmatic nucleus most probably by biochemical signaling through the cerebrospinal fluid (Quintela et al, 2021).…”

Section: Choroid Plexusmentioning

confidence: 99%

Organization of the ventricular zone of the cerebellum

Gómez-González

Becerra-González²,

Martínez-Mendoza³

et al. 2022

Front. Cell. Neurosci.

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The roof of the fourth ventricle (4V) is located on the ventral part of the cerebellum, a region with abundant vascularization and cell heterogeneity that includes tanycyte-like cells that define a peculiar glial niche known as ventromedial cord. This cord is composed of a group of biciliated cells that run along the midline, contacting the ventricular lumen and the subventricular zone. Although the complex morphology of the glial cells composing the cord resembles to tanycytes, cells which are known for its proliferative capacity, scarce or non-proliferative activity has been evidenced in this area. The subventricular zone of the cerebellum includes astrocytes, oligodendrocytes, and neurons whose function has not been extensively studied. This review describes to some extent the phenotypic, morphological, and functional characteristics of the cells that integrate the roof of the 4V, primarily from rodent brains.

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“…During the last decades, a considerable number of studies had given significance to these issues (Kavakli et al, 2022; Quintela et al, 2021; Stangherlin et al, 2021; Yao et al, 2021). In this review, we summarize several diseases associated with clock mechanisms and some clock‐based therapeutic strategies for clinical implementation of chronotherapy in a near future (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythm and disease: Relationship, new insights, and future perspectives

Neves

Albuquerque

Quintela

et al. 2022

Journal Cellular Physiology

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The circadian system is responsible for internal functions and regulation of the organism according to environmental cues (zeitgebers). Circadian rhythm dysregulation or chronodisruption has been associated with several diseases, from mental to autoimmune diseases, and with life quality change. Following this, some therapies have been developed to correct circadian misalignments, such as light therapy and chronobiotics. In this manuscript, we describe the circadian‐related diseases so far investigated, and studies reporting relevant data on this topic, evidencing this relationship, are included. Despite the actual limitations in published work, there is clear evidence of the correlation between circadian rhythm dysregulation and disease origin/development, and, in this way, clock‐related therapies emerge as great progress in the clinical field. Future improvements in such interventions can lead to the development of successful chronotherapy strategies, deeply contributing to enhanced therapeutic outcomes.

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The role of circadian rhythm in choroid plexus functions

Cited by 26 publications

References 139 publications

The relationship between choroidal thickness and axis length and corneal curvature in high myopia

The relationship between choroidal thickness and axis length and corneal curvature in high myopia

Organization of the ventricular zone of the cerebellum

Circadian rhythm and disease: Relationship, new insights, and future perspectives

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