The role of circular folds in mixing intensification in the small intestine: A numerical study

Zha, Jinping; Zou, Siyu; Hao, Jianyu; Liu, Xinjuan; Delaplace, Guillaume; Jeantet, Romain; Dupont, Didier; Wu, Peng; Chen, Xiao; Xiao, Jie

doi:10.1016/j.ces.2020.116079

Cited by 26 publications

(21 citation statements)

References 38 publications

(44 reference statements)

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“…[5,18,19] to quantify mixing by longitudinal and circumferential contractions using residence time analysis. A recent study has quantified mixing and its dependence on circular folds with varying segmentation amplitude, frequency, and velocity by numerical simulations [20].…”

Section: Introductionmentioning

confidence: 99%

Flow and mixing induced by single, colinear, and colliding contractile waves in the intestine

Agbesi

Chevalier

2022

Phys. Rev. Fluids

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Smooth muscle-lined organs like the gut, the ureter, and the fallopian tubes transport matter by generating traveling contractile waves. Intestinal peristalsis is characterized by rhythmic trains of shallow, low-amplitude myogenic waves and high-amplitude, lumenobliterating neurogenic waves. In this paper, we develop a simple analytical Poiseuille-flow model to predict the flow rates induced by these different contractions as a function of all relevant wave parameters, and compare them to a numerical fluid-solid finite element model. We rationalize experimentally observed bolus to-and-fro motion induced by shallow myogenic waves. We show that occluding waves induce considerable bolus mixing due to an upstream vortex. We then investigate the hydrodynamics induced by two waves propagating either in the same direction (colinear) or in opposite directions, as happens in the digestive tract. For colinear waves, we find that the bolus reflux is maximal at a distance between successive myogenic waves close to the one observed physiologically. Colliding waves create a high pressure region that gives rise to rapid fluid flow, high shear stress, and radial mixing upon annihilation. Our paper provides fundamental insight on the fluid dynamics (reflux, propulsion, and mixing) generated by different contraction patterns of the intestine.

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Section: Introductionmentioning

confidence: 99%

Flow and mixing induced by single, colinear, and colliding contractile waves in the intestine

Agbesi

Chevalier

2022

Phys. Rev. Fluids

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“…The digestion of solid foods such as cooked rice is a complicated process within the human GIT, which includes two aspects: mechanical digestion (chewing with teeth, segmentation, and peristalsis of the GIT) and biochemical and enzymatic interactions (the role of digestive fluids; Capuano & Janssen, 2021; Zha et al, 2021). Saliva and gastric juice play important roles in the digestion of cooked rice.…”

Section: Introductionmentioning

confidence: 99%

The surface mechanics of cooked rice as influenced by gastric fluids measured using a micro texture analyzer

Chen

2022

Journal of Texture Studies

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In this study, a micro texture analyzer (MTA) was employed to explore the texture characteristics of the surface of an individual steamed rice (SR) and fried rice (FR) grain exhibited in four simulated digestion environments in vitro. The elastic modulus, hardness and elastic index of the single cooked rice particle were measured using the MTA. The hardness of SR particles decreased by 66, 81, 89.1, and 95% after simulated digestion in distilled water, HCl, simulated gastric fluid (SGF), and simulated salivary and gastric fluid (SSF + SGF), respectively. This is in line with the most significant volume expansion and structure ruptures when digested in SSF + SGF. Similar mechanical and structural behaviors were shown for FR, but the hardness and elastic modulus decreased less than those of SR under the same digestion conditions. The different surface mechanics are consistent with the reduced expansion and more compact structure with smaller voids in FR during in vitro digestion. This could be attributed to the encapsulation by frying oil on the surface that would retard the diffusion of digestive fluids into the rice kernels. A weak negative correlation was found between the elastic modulus and the moisture content of the cooked rice. The present study has quantitatively assessed the surface mechanics of cooked rice as influenced by gastric fluids using the MTA. This is practically meaningful for gaining an in‐depth understanding of the influence of textural modifications on disintegration of solid foods and release of nutrients during digestion.

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“…Computational Fluid Dynamics (CFD) has been applied extensively to investigate flow characteristics and is a recognized method for designing and optimizing devices in a broad range of conventional engineering applications (Gao et al, 2016;Liu et al, 2019;Mosavi et al, 2019;Shamshirband et al, 2020;Zhang et al, 2016). The method can also be applicable to the study of mixing in human digestive organs, such as the stomach and intestines, whose walls keep wriggling during digestion (Alokaily et al, 2019;Ferrua & Singh, 2010;Zha et al, 2021). This method is quite suited to analyse the mixing process in SERs for exploring various influencing factors, because carrying out in silico experiments can be cost effective, and comprehensive flow field data can be obtained.…”

Section: Introductionmentioning

confidence: 99%

Simulation based investigation of 2D soft-elastic reactors for better mixing performance

Gasow

Jin

et al. 2021

Engineering Applications of Computational Fluid Mechanics

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The role of circular folds in mixing intensification in the small intestine: A numerical study

Cited by 26 publications

References 38 publications

Flow and mixing induced by single, colinear, and colliding contractile waves in the intestine

Flow and mixing induced by single, colinear, and colliding contractile waves in the intestine

The surface mechanics of cooked rice as influenced by gastric fluids measured using a micro texture analyzer

Simulation based investigation of 2D soft-elastic reactors for better mixing performance

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