The Role of Circular RNAs in Cerebral Ischemic Diseases: Ischemic Stroke and Cerebral Ischemia/Reperfusion Injury

Yang, Jian; Chen, Mengli; Cao, Yanxiang; Li, Qing; Zhu, Fubao

doi:10.1007/978-981-13-1426-1_25

Cited by 65 publications

(39 citation statements)

References 168 publications

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“…These processes can facilitate rapid changes in the ischemic-sensitive transcriptome. In addition, post-ischemic pathophysiological changes can be fine-tuned by the regulation of post-transcriptional RNA levels 98 via non-coding RNAs, RNA-binding proteins, and epigenetic post-transcriptional modifications 99,100 . The "eraser" of m 6 A methylation, FTO, is highly enriched in the brain, where its deletion results in impaired dopaminergic neurotransmission and congenital microcephaly 101 .…”

Section: Epigenetic Regulations In Ischemia-reperfusion Injurymentioning

confidence: 99%

N6-methyladenosine (m6A) methylation in ischemia–reperfusion injury

Yao

Han

et al. 2020

Cell Death Dis

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Ischemia-reperfusion (I/R) injury is common during surgery and often results in organ dysfunction. The mechanisms of I/R injury are complex, diverse, and not well understood. RNA methylation is a novel epigenetic modification that is involved in the regulation of various biological processes, such as immunity, response to DNA damage, tumorigenesis, metastasis, stem cell renewal, fat differentiation, circadian rhythms, cell development and differentiation, and cell division. Research on RNA modifications, specifically N6-methyladenosine (m 6 A), have confirmed that they are involved in the regulation of organ I/R injury. In this review, we summarized current understanding of the regulatory roles and significance of m 6 A RNA methylation in I/R injury in different organs.

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Section: Epigenetic Regulations In Ischemia-reperfusion Injurymentioning

confidence: 99%

N6-methyladenosine (m6A) methylation in ischemia–reperfusion injury

Yao

Han

et al. 2020

Cell Death Dis

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“…CircRNA is more diverse in neuronal tissue than other tissues [2] and plays critical roles in brain diseases, such as cerebrovascular disease and neurodegenerative disease. [3,4] Recently, evidences suggested that the key role of circRNAs in the molecule mechanism of glioma development, [5,6] where some circRNA promote glioma malignancy [7,8] and some circRNA inhibit glioma progression. [9] It is still few evidences of the role of circZNF609 in glioma carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

CircZNF609/miR-134-5p/BTG-2 axis regulates proliferation and migration of glioma cell

Tong

Zhao

Wang

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives MicroRNAs are abundant in eukaryotic cells and play key roles in cancers. Circular RNAs (CircRNAs) served as the competing endogenous RNAs (ceRNAs) in mediating multiple cell processes. This study aims to define the role of CircRNA CircZNF609/miR‐134‐5p in glioma as well as the underlying regulating mechanism. Methods Relative expression of miR‐134‐5p, CircZNF609 and BTG‐2 mRNA was determined by quantitative real‐time PCR. Cell proliferation was analysed by CCK‐8 assay. Cell migration was assessed by cell wound scratch assay. The direct regulatory of miR‐134‐5p on BTG‐2 and CircZNF609 was verified by luciferase report gene assay. Key findings MiR‐134‐5p was significantly upregulated in glioma cells. The overexpression of miR‐134‐5p inhibited cell proliferation and migration of glioma cell U251 and U87. Reversely, knock‐down of miR‐134‐5p enhanced cell proliferation and migration. Both BTG‐2 and CircZNF609 are the direct targets of miR‐134‐5p, and their expression could be negatively regulated by miR‐134‐5p. CircZNF609 was significantly upregulated in U251 and U87 cells and acted as an oncogene to promote cell proliferation and cell migration of glioma cell U251 and U87. Conclusions These data proved that CircZNF609 served as a competing RNA to bind miR‐134‐5p that promoted BTG‐2 expression leading to reduced proliferation and migration of glioma cell.

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“…1 Since the brain tissue is the most sensitive organ to hypoxia, cerebral ischemia results in dysfunction of the brain, as well as other organs that are controlled by the cerebral ischemic regions. 1,2 Ischemic stroke is among the leading causes of deaths and disability in the world and brings heavy nancial and mental burden to both society and family. 3 It has been surveyed that approximately 15 million people suffer from stroke worldwide each year.…”

Section: Introductionmentioning

confidence: 99%

“…However, this process bears risks of worsening the original brain damage caused by ischemia. 2 That is because that various free radicals are released during the reperfusion progress. 2,7 The excessive free radicals may result in oxidative damage, leading to the activation of inammatory cascade reaction, promotion of cellular apoptosis and breakdown of blood-brain barrier, which are much more sophisticated than ischemia alone.…”

Section: Introductionmentioning

confidence: 99%

“…2 That is because that various free radicals are released during the reperfusion progress. 2,7 The excessive free radicals may result in oxidative damage, leading to the activation of inammatory cascade reaction, promotion of cellular apoptosis and breakdown of blood-brain barrier, which are much more sophisticated than ischemia alone. 5,8 Therefore, intervention of I/R injury is critical for treatment of patients with ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

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