The Role of Collagen Bioscaffolds, Foamed Collagen, and Living Skin Equivalents in Wound Healing

Landsman, Adam; Taft, Drew; Riemer, Kevin

doi:10.1016/j.cpm.2009.08.012

Cited by 31 publications

(23 citation statements)

References 8 publications

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“…It has been shown that MSCs exhibit similar biological functions to dermal fibroblasts in the wound‐healing process, and similarly to fibroblasts they migrate toward injured tissues . These MSCs by themselves have the capability of secreting fibronectin, growth factors, and collagen which are essential for matrix reorganization increasing the strength and integrity of injured tissue , , , . Here we show that MSC‐coated sutures may have a beneficial effect in the wound healing by increasing the collagen depositions in the sutured tissues.…”

Section: Discussionsupporting

confidence: 52%

Mesenchymal stem cell‐coated sutures enhance collagen depositions in sutured tissues

Casado

Blázquez

Jorge

et al. 2014

Wound Repair Regeneration

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Sutures are commonly used for surgical procedures and new sutures are being developed to improve wound healing. In the past decade, it has been extensively shown that mesenchymal stem cells (MSCs) have a wound healing potential. To benefit the overall wound healing process, we aimed to analyze the usage of pretreated sutures for improving the implantation of MSCs in the tissues. Our results firstly showed that suture pretreatments with gelatin, poly-L-lysine, and NaOH improved the adhesive strength of MSCs to sutures. These cells remained surrounding the sutured tissue and no significant phenotypic changes were found in those cells cultured onto pretreated sutures. In vivo experiments showed that the implantation of MSCs by suturing increases the collagen content in the sutured tissue. Moreover, proteomics analysis of secreted proteins showed that collagen alpha-1(I) chain was the most abundant collagen found. To our knowledge, this is the first report that aimed to improve the implantation of MSCs in tissue by suture pretreatments. Moreover, in vivo experiments suggest that MSC-coated sutures may enhance wound healing and tissue remodeling through the release of different collagen types being applicable for those patients that tend to have difficulty healing.

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Section: Discussionsupporting

confidence: 52%

Mesenchymal stem cell‐coated sutures enhance collagen depositions in sutured tissues

Casado

Blázquez

Jorge

et al. 2014

Wound Repair Regeneration

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“…Collagen not only confers strength and integrity to the tissue matrix but also plays an important role in homeostasis and epithelialization in the later stages of wound healing [15]. Hydroxyproline is an uncommon amino acid present in the collagen fibers of granulation tissues.…”

Section: Discussionmentioning

confidence: 99%

Wound repair and anti-inflammatory potential of Lonicera japonica in excision wound-induced rats

Chen

Liou

Tzeng

et al. 2012

BMC Complement Altern Med

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BackgroundLonicera japonica Thunb. (Caprifoliaceae), a widely used traditional Chinese medicinal plant, is used to treat some infectious diseases and it may have uses as a healthy food and applications in cosmetics and as an ornamental groundcover. The ethanol extract of the flowering aerial parts of L. japonica (LJEE) was investigated for its healing efficiency in a rat excision wound model.MethodsExcision wounds were inflicted upon three groups of eight rats each. Healing was assessed by the rate of wound contraction in skin wound sites in rats treated with simple ointment base, 10% (w/w) LJEE ointment, or the reference standard drug, 0.2% (w/w) nitrofurazone ointment. The effects of LJEE on the contents of hydroxyproline and hexosamine during healing were estimated. The antimicrobial activity of LJEE against microorganisms was also assessed. The in vivo anti-inflammatory activity of LJEE was investigated to understand the mechanism of wound healing.ResultsLJEE exhibited significant antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans, and Candida tropicalis. The ointment formulation prepared with 10% (w/w) LJEE exhibited potent wound healing capacity as evidenced by the wound contraction in the excision wound model. The contents of hydroxyproline and hexosamine also correlated with the observed healing pattern. These findings were supported by the histopathological characteristics of healed wound sections, as greater tissue regeneration, more fibroblasts, and angiogenesis were observed in the 10% (w/w) LJEE ointment-treated group. The results also indicated that LJEE possesses potent anti-inflammatory activity, as it enhanced the production of anti-inflammatory cytokines that suppress proinflammatory cytokine production.ConclusionsThe results suggest that the antimicrobial and anti-inflammatory activities of LJEE act synergistically to accelerate wound repair.

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“…Collagen may be harvested from a variety of sources including living and nonliving bovine, porcine, and equine skin. Once harvested (via a proprietary process), a native collagen bioscaffold matrix is created that stabilizes the vascular and cellar components, which become incorporated into the wound bed 1. Preliminary findings suggest that collagen-containing wound dressings may have several advantageous features.…”

Section: Introductionmentioning

confidence: 99%

Collagen-based wound dressings for the treatment of diabetes-related foot ulcers: a systematic review

Holmes¹,

Wrobel²,

MacEachern³

et al. 2013

DMSO

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BackgroundDiabetic foot ulcers are a major source of morbidity, limb loss, and mortality. A prolonged inflammatory response, extracellular matrix degradation irregularities, and increased bacteria presence have all been hypothesized as major contributing factors in the delayed healing of diabetic wounds. Collagen components such as fibroblast and keratinocytes are fundamental to the process of wound healing and skin formation. Wound dressings that contain collagen products create a biological scaffold matrix that supports the regulation of extracellular components and promotes wound healing.MethodsA systematic review of studies reporting collagen wound dressings used in the treatment of Diabetic foot ulcers was conducted. Comprehensive searches were run in Ovid MEDLINE, PubMed, EMBASE, and ISI Web of Science to capture citations pertaining to the use of collagen wound dressings in the treatment of diabetic foot ulcers. The searches were limited to human studies reported in English.ResultsUsing our search strategy, 26 papers were discussed, and included 13 randomized designs, twelve prospective cohorts, and one retrospective cohort, representing 2386 patients with diabetic foot ulcers. Our design was not a formal meta-analysis. In those studies where complete epithelialization, 58% of collagen-treated wounds completely healed (weighted mean 67%). Only 23% of studies reported control group healing with 29% healing (weighted mean 11%) described for controls.ConclusionCollagen-based wound dressings can be an effective tool in the healing of diabetic foot wounds. The current studies show an overall increase in healing rates despite limitations in study designs. This study suggests that future works focus on biofilms and extracellular regulation, and include high risk patients.

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The Role of Collagen Bioscaffolds, Foamed Collagen, and Living Skin Equivalents in Wound Healing

Cited by 31 publications

References 8 publications

Mesenchymal stem cell‐coated sutures enhance collagen depositions in sutured tissues

Mesenchymal stem cell‐coated sutures enhance collagen depositions in sutured tissues

Wound repair and anti-inflammatory potential of Lonicera japonica in excision wound-induced rats

Collagen-based wound dressings for the treatment of diabetes-related foot ulcers: a systematic review

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