The role of computer-assisted analysis in the evaluation of nuclear characteristics for the diagnosis of precancerous and cancerous lesions by contact laryngoscopy

Tarnawski, Wojciech; Frączek, Marcin; Jeleń, Michał; Kręcicki, Tomasz; Zalesska−Kręcicka, Maria

doi:10.2478/v10039-008-0046-4

Cited by 9 publications

(13 citation statements)

References 14 publications

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“…Tarnawski et al [31] examined 54 patients with various laryngeal pathology intraoperatively during microlaryngoscopy. CE was performed, and biopsies were taken from all patients for histopathological diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…Since the development of contact endoscopy, this technology has been used successfully by several authors in analyzing and diagnosing various pathologies of the larynx, oral cavity, oropharynx, and nasopharynx via “real-time” examination of mucosal cytological detail [4, 26–31, 33–36]. Despite its introduction into otolaryngology, CE has yet to find a place in routine clinical practice despite its potential advantages.…”

Section: Discussionmentioning

confidence: 99%

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Contact Endoscopy as a Novel Technique in the Detection and Diagnosis of Mucosal Lesions in the Head and Neck: A Brief Review

Szeto

Wehrli

Whelan

et al. 2011

Journal of Oncology

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Background. There are a variety of described noninvasive optical detection techniques for evaluation of head and neck mucosal lesions. Contact endoscopy is a promising method of in vivo microscopic examination whereby a rigid telescope is placed on a previously dye-stained mucosa allowing evaluation of the superficial cell layers of the epithelium. This technique produces real-time, magnified images of cellular architecture of surface mucosa comparable to histology without the need for biopsy. In this review, we will briefly summarize the efficacy of CE in the detection of precancerous and cancerous mucosal lesions and its potential as a novel technique in early diagnosis, monitoring, and preoperative assessment of mucosal lesions of the head and neck. Methods. PUBMED, MEDLINE, and COCHRANE search revealed five prospective articles on contact endoscopy for the diagnosis of mucosal lesions in the head and neck. Results. The literature search yielded five prospective studies examining contact endoscopy for the diagnosis of benign versus malignant head and neck mucosal lesions. These reported a sensitivity and specificity of 77–100%, specificity of 66–100% and an accuracy of 72–92%. Conclusion. Contact endoscopy is a promising optical technology that may be a useful adjunct in the evaluation and diagnosis of benign and malignant head and neck mucosal lesions. Future prospective randomized double-blind studies of this detection method are required.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Contact Endoscopy as a Novel Technique in the Detection and Diagnosis of Mucosal Lesions in the Head and Neck: A Brief Review

Szeto

Wehrli

Whelan

et al. 2011

Journal of Oncology

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“…Tarnawski et al [14] performed CE on 54 patients with various laryngeal pathologies intraoperatively during microlaryngoscopy. Their results were based on computerassisted analysis of all CE images for certain nuclear morphometric parameters.They reported, on computerassisted analysis of CE images, 100% sensitivity and specificity for diagnosis of Squamous cell carcinoma and severe dysplasia but overall sensitivity and specificity for all lesions put together was only 91% and 81% respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Only four studies have calculated sensitivity, specificity and accuracy indices. [7,[13][14][15] Common findings on examination of cellular architecture and vascular patterns described by various authors on CE of larynx are tabulated in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…[7][8][9][13][14][15][16][17][18]20] These results have Other conditions: Metaplasia: Presence of squamous epith in the areas where normally columnar epithelium is found, Papilloma: Epith shows convolutions, every convolution having independent vascular axis, papillae with cells arranged in whorls seen, Koilocytosis present, Reinke's Oedema: Homogenous pattern, larger nuclei, increased nuclear density, high nucleus-cytoplasm ratio, surface of vocal cord wholly covered by squamous, Epithelium with transition zone detectable only at the ventricle level been obtained taking the histopathological examination as the gold standard. However, the technique of CE has definite advantages and limitations.…”

Section: Discussionmentioning

confidence: 99%

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Contact Endoscopy - A promising tool for evaluation of laryngeal mucosal lesions

Mishra¹,

Nilakantan

Datta³

et al. 2012

J Laryngol Voice

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Interrater variation of vascular classifications used in enhanced laryngeal contact endoscopy

Mehlum

Døssing

Davaris

et al. 2020

Eur Arch Otorhinolaryngol

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The role of computer-assisted analysis in the evaluation of nuclear characteristics for the diagnosis of precancerous and cancerous lesions by contact laryngoscopy

Cited by 9 publications

References 14 publications

Contact Endoscopy as a Novel Technique in the Detection and Diagnosis of Mucosal Lesions in the Head and Neck: A Brief Review

Contact Endoscopy as a Novel Technique in the Detection and Diagnosis of Mucosal Lesions in the Head and Neck: A Brief Review

Contact Endoscopy - A promising tool for evaluation of laryngeal mucosal lesions

Interrater variation of vascular classifications used in enhanced laryngeal contact endoscopy

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