The role of conventional and functional MRI in diagnosis of breast masses

Teama, Atef Hammad; Hassanien, Omar Ahmed; Hashish, Amal Abd-Eltawab; Shaarawy, Hagar Ahmed

doi:10.1016/j.ejrnm.2015.05.014

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…Several authors have demonstrated that the number of benign breast lesions among the lesions with type I contrast enhancement kinetic was larger than that among lesions with type II or type III contrast kinetics. It means that the lesions with type I contrast kinetic tend to be benign (36,40–42). In addition, the number of malignant breast lesions was larger among the lesions with type III contrast enhancement kinetic than that among the lesions with type I or type II contrast enhancement kinetics (36,40–42).…”

Section: Discussionmentioning

confidence: 99%

Accuracy of multiparametric MRI in distinguishing the breast malignant lesions from benign lesions: a meta-analysis

et al. 2020

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Background The sensitivity of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for detecting breast cancer was high and the specificity was relatively low. However, diffusion-weighted imaging (DWI) has a high specificity in the diagnosis of malignant lesions. Purpose To evaluate the accuracy of the multiparametric MRI (mp-MRI) in distinguishing the breast malignant lesions from the benign lesions. Material and Methods A comprehensive search of the PubMed, Embase, and Cochrane Library electronic databases was conducted up to March 2020. Data were analyzed for the following indexes: pooled sensitivity and specificity; positive likelihood ratio; negative likelihood ratio; diagnostic odds ratio; and the area under the curve. Results A total of 2356 patients with 1604 malignant and 967 benign breast lesions were included from 22 studies. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve for mp-MRI were 0.93, 0.85, 6.3, 0.08, 81, and 0.96, respectively. The pooled sensitivity, specificity, and area under the curve for DCE-MRI alone were 0.95, 0.71, and 0.92, respectively. The pooled sensitivity, specificity, and area under the curve for DWI alone were 0.88, 0.84, and 0.93, respectively. Conclusion The mp-MRI did not improve the sensitivity but increased the specificity for the diagnosis of breast malignant lesions.

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Section: Discussionmentioning

confidence: 99%

Accuracy of multiparametric MRI in distinguishing the breast malignant lesions from benign lesions: a meta-analysis

et al. 2020

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“…Similarly, Teama and co-workers 19 found that of 10 patients with malignant lesion of their study, 6 patients showed restricted diffusion and out of 21 patients with benign breast lesions 19 patients showed non-restricted diffusion. The explanation of this phenomenon is from understanding the mode of action of DWI.…”

Section: Resultsmentioning

confidence: 62%

“…Similarly, benign and malignant lesions had different ADC levels inCai et al 5 . In Teamaet alstudy has been found that the mean ADC value was significantly lower (0.5-0.9 • 10×3 mm 2 /s) for malignant lesion in comparison with that of benign lesions (1.7-2.7 • 10×3 mm 2 /s) 19 . InBostanBozkurt et al (2016) 23 study, it has been found that the mean ADC values of malignant lesions were significantly different from that of benign lesions (1.04±0.29x10-3 mm 2 /s, Vs. 1.61±0.50x10-3 mm 2 /s) respectively, with high statistical significant difference (p=0.03).…”

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confidence: 92%

“…InFusco et al study, DCE-MRI has shown high sensitivity and specificity for breast cancer detection (89%, 100%) respectively 22 . InTeama et al study, they found that DCE-MRI had sensitivity(92.3%), specificity (81%) and accuracy (85.3%) 19 . InMatar study, the sensitivity of using DWI was 85% specificity of 93.33%, positive predictive value of 94.4%, negative predictive value of 82.4% with diagnostic accuracy of 90.3% 15 .…”

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confidence: 92%

“…In contrast, Teama and Coworkers reported a raised specificity from 81% to 90.5% and a slightly improved PPV from 75% to 77.8% without any improvement in sensitivity (53.8%). NPV was 76% and accuracy was 76.5% when combine both modalities 19 . In Hassan et al study, applying an ADC threshold of 1.3×10*3 mm2/s sensitivity increased (on conventional DCE-MRI basis) from 86.95% up to 93.47% and the specificity from 91.22% to 96.49% in detection of malignancy with PPV of 95.55% in comparison to 86.95% for enhancement kinetics alone, which would have avoided biopsy for 10.5% (6/57) of benign lesions without missing any cancers 14 .…”

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confidence: 97%

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The Role of Dynamic Contrast Enhanced and Diffusion Weighted MRI in Characterization of Suspicious Breast Masses

Abdullah

Othman

Hussein

2017

EJHM

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Background: Early detection and diagnosis of breast cancer are mandatory for accurate management. Traditionally, mammography and ultrasound are the basic imaging techniques for the detection and localization of breast masses. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities. Aim of study: to evaluate the role of either diffusion weighted images-MRI or dynamic contrast enhanced MRI in differentiating malignant from benign breast lesions comparing with histopathology results. Patients and Methods: from November 2016 to July 2017, a total of 20 patients presented with suspicious breast lesions BIRADS (4&5) were included in the study. All participants underwent breast DWI and DCE-MRI. Results were compared with histopathological results as a standard final diagnostic method. Results: the study included 20 female patients with suspicious breast lesions, there was 15 (75%) malignant lesions while benign lesions, while benign lesions were 5 (25%) cases. DCE-MRI was found to have a sensitivity of 86.7% and specificity of 80%. ADC cutoff value was found to have a value of 1.143*10-3 , which was the best to differentiate between benign and malignant breast masses. DWI MRI was found to have sensitivity of 93.3% and a specificity of 80%. Conclusion: DW-MRI alone gave the same performance as in combination with DCE-MRI. The comparison of DWI and DCE-MRI provides a dramatic superiority in the sensitivity, specificity and accuracy of breast DWI-MRI over other modality.

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Breast Lesions: Diagnosis Using Diffusion Weighted Imaging at 1.5T and 3.0T—Systematic Review and Meta-analysis

Shi

Yao

et al. 2018

Clinical Breast Cancer

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The role of conventional and functional MRI in diagnosis of breast masses

Cited by 7 publications

References 26 publications

Accuracy of multiparametric MRI in distinguishing the breast malignant lesions from benign lesions: a meta-analysis

Accuracy of multiparametric MRI in distinguishing the breast malignant lesions from benign lesions: a meta-analysis

The Role of Dynamic Contrast Enhanced and Diffusion Weighted MRI in Characterization of Suspicious Breast Masses

Breast Lesions: Diagnosis Using Diffusion Weighted Imaging at 1.5T and 3.0T—Systematic Review and Meta-analysis

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