Liver-specific contrast agents (CAs) can improve the Magnetic resonance imaging (MRI) detection of focal and diffuse liver lesions by increasing the lesion-to-liver contrast. A novel Mn­(II) complex, Mn-BnO-TyrEDTA, with a lipophilic group-modified ethylenediaminetetraacetic acid (EDTA) structure as a ligand to regulate its behavior in vivo, is superior to Gd-EOB-DTPA in terms of a liver-specific MRI contrast agent. An MRI study on mice demonstrated that Mn-BnO-TyrEDTA can be rapidly taken up by hepatocytes with a combination of hepatobiliary and renal clearance pathways. Bromosulfophthalein (BSP) inhibition imaging, biodistribution, and cellular uptake studies confirmed that the mechanism of hepatic targeting of Mn-BnO-TyrEDTA is the hepatic uptake of the amphiphilic anion contrast agent mediated by organic anion transporting polypeptides (OATPs) expressed by functional hepatocytes.

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Objective We conducted this meta-analysis to assess the effectiveness of parathyroid gland autotransplantation in preserving parathyroid function during thyroid surgery for thyroid neoplasms. Methods We conducted a search by using PubMed, Embase, and the Cochrane Library electronic databases for studies that were published up to January 2019. The reference lists of the retrieved articles were also reviewed. Two authors independently assessed the methodological quality and extracted the data. A random-effects model was used to calculate the overall combined risk estimates. Publication bias was evaluated with a funnel plot using Egger’s and Begg’s tests. Results A total of 25 independent studies involving 10,531 participants were included in the meta-analysis. Compared with patients who did not undergo parathyroid gland autotransplantation, the overall pooled relative risks for patients who underwent parathyroid gland autotransplantation were 1.75 (95% CI: 1.51–2.02, p<0.001) for postoperative hypoparathyroidism, 1.72 (95% CI: 1.45–2.05, p<0.001) for protracted hypoparathyroidism, 1.06 (95% CI: 0.44–2.58, p = 0.894) and 0.71 (95% CI: 0.22–2.29, p = 0.561) for biochemical hypoparathyroidism and biochemical hypocalcemia at 6 months postoperatively, respectively, and 1.89 (95% CI: 1.33–2.69, p<0.001) and 0.22 (95% CI: 0.09–0.52, p = 0.001) for biochemical hypoparathyroidism and biochemical hypocalcemia at 12 months postoperatively, respectively. The pooled relative risks for patients who underwent one parathyroid gland autotransplantation and patients who underwent two or more parathyroid gland autotransplantations were 1.71 (95% CI: 1.25–2.35, p = 0.001) and 2.22 (95% CI: 1.43–3.45, p<0.001) for postoperative hypoparathyroidism, 1.09 (95% CI: 0.59–2.01, p = 0.781) and 0.55 (95% CI: 0.16–1.87, p = 0.341) for hypoparathyroidism at 6 months postoperatively compared with those of patients who did not undergo parathyroid gland autotransplantation. Conclusions Parathyroid gland autotransplantation is significantly associated with increased risk of postoperative and protracted hypoparathyroidism, and the number of autoplastic parathyroid glands is positively correlated with the incidence of postoperative hypoparathyroidism.

Conjugated and short-molecule capping ligands have been demonstrated as a valid strategy for achieving high-efficiency perovskite nanocrystal (NCs) light-emitting diodes (LEDs) owing to their advantage of allowing efficient carrier transport between NCs. However, monotonously utilizing conjugated ligands cannot achieve sufficient surface modification/passivation for perovskite NCs, leading to their poor photoluminescence quantum yield (PLQY) and dispersibility. This work designs a complementary ligand synthesis method to obtain high-quality methylamine lead bromide (MAPbBr 3 ) NCs and then leverage them into efficient LEDs. The complementary ligand system combines a conjugated ligand 3-phenyl-2-propen-1-amine (PPA) and a long-chain ligand didodecyldimethylammonium bromide (DDAB) together with a well-known inductive inorganic ligand ZnBr 2 . With such complementary ligand engineering, we significantly improve the emissive features of MAPbBr 3 NCs (PLQY: 99% ± 0.7%). Simultaneously, the complementary ligand strategy facilitated the adequate charge transportation in related NCs films and modified the interfacial energy-level alignment when the NCs assemble as an emitting layer into LEDs. Finally, based on this NCs synthesis method, highefficiency green LEDs were achieved, exhibiting the maximum luminance of 1.59 × 10 4 cd m −2 , a current efficiency of 23.7 cd A −1 , and an external quantum efficiency of 7.8%. Our finding could provide a new avenue for further development of LEDs and their commercial application.

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