The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs

Boyle, E; Freeman, Patricia C.; Goudie, A. C.; Mangan, F. R.; Thomson, M.

doi:10.1111/j.2042-7158.1976.tb04081.x

Cited by 67 publications

(21 citation statements)

References 9 publications

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“…The claim has been made that the copper salts of a variety of ligands including antiinflammatory drugs (AID) possess AI activity greater than the ligand itself [11. The observation that copper complexes of certain AID, including aspirin, reduced gastric side effects of the AID produced in the rat [ 1] has been verified by others [5]. The observation that copper complexes of certain AID, including aspirin, reduced gastric side effects of the AID produced in the rat [ 1] has been verified by others [5].…”

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confidence: 81%

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A comparison of the anti-inflammatory effects of copper aspirinate and other copper salts in the rat and guinea pig

Lewis¹

1978

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A comparison of the anti-inflammatory (AI) activity of copper compounds in models of kaolin-induced paw oedema and u.v. erythema in the rat and guinea pig is described. The results demonstrated considerable species variation, the guinea pig being more sensitive to the AI and irritant effects of copper aspirinate and the other copper compounds. The route of administration of these compounds was also an important factor in interpreting AI activity obtained. Indeed, the counter-irritation effects of the copper compounds may be largely responsible for the AI activity obtained after subcutaneous administration. The comparison between copper aspirinate and aspirin, performed in order to determine whether a copper complex of an AI drug was more active than the parent AI compound, failed to produce a clear difference in activity although copper aspirinate was more effective than aspirin in certain cases. It is concluded that this study highlights the complexities of copper therapy against inflammatory processes and furthermore indicates the importance of species, the model of inflammation and route of drug administration in interpreting data obtained with copper containing compounds.

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confidence: 81%

“…Considerable interest has centred recently on the anti-inflammatory (AI) activity of copper salts [1][2][3][4][5]. The claim has been made that the copper salts of a variety of ligands including antiinflammatory drugs (AID) possess AI activity greater than the ligand itself [11.…”

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confidence: 99%

A comparison of the anti-inflammatory effects of copper aspirinate and other copper salts in the rat and guinea pig

Lewis¹

1978

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“…Since tetrakis-g-2-[3-trifluoromethyl)phenyl] aminonicotinatodicopper (II) [Cu(II)2 (niflumate)4] is known to be a more effective anti-inflammatory agent [1,4] and analgesic agent [5] than niflumic acid and Cu(II)2(niflumate)4 is an effective antiulcer agent [1,2,6] unlike niflumic acid, which is ulcerogenic, the question arose as to the difference in mechanistic effectiveness of these compounds in modulating polymorphonuclear leukocyte (PMNL) reactivity in response to inflammation.…”

Section: Introductionmentioning

confidence: 99%

Modulation of polymorphonuclear leukocyte responsiveness by copper (II)2 (niflumate)4

et al. 1995

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Antiinflammatory activities and modulations of PMNL responses produced by treatment with tetrakis-mu-2-[3-(trifluoromethyl)-phenyl]aminonicotinatodicopper (II) [Cu(II)2(niflumate)4] and niflumic acid were studied in isologous serum-induced rat pleurisy. Doses of 10 or 30 mg/kg (35 or 106 mumol/kg) of niflumic acid or Cu(II)2(niflumate)4 (8 or 23 mumol/kg) caused significant (p < 0.01) reductions in pleural exudate and number of polymorphonuclear leukocytes (PMNLs) in the exudate. While both doses of Cu(II)2(niflumate)4 produced significant dose-related reductions in both parameters, only the higher dose of niflumic acid produced a significant dose-related reduction in both parameters. Boyden chamber measurements of N-formyl-methionyl-leucyl-phenylalanine (f-MLP) chemotaxis by PMNLs incubated with 10 or 30 micrograms/ml niflumic acid (35 or 106 nmol/ml) or Cu(II)2(niflumate)4 (8 or 23 nmol/ml) were significantly (p < 0.01 to p < 0.001) decreased in dose-related fashions. Chemotaxis of PMNLs from pleuritic rats treated orally with 10 or 30 mg/kg niflumic acid or Cu(II)2(niflumate)4 was significantly (p < 0.001) inhibited by the larger dose of niflumic acid and both doses of Cu(II)2(niflumate)4. Opsonized zymosan (OZ)-stimulated chemiluminescence (CL) of PMNLs from pleuritic rats treated orally with these same doses of niflumic acid or Cu(II)2(niflumate)4 was only significantly (p < 0.05 or p < 0.01 respectively) decreased by the larger doses. Superoxide (O2-) production by these cells was significantly decreased by the larger dose of niflumic acid (p < 0.05) while both doses of Cu(II)2(niflumate)4 produced significant (p < 0.05 to p < 0.01) decreases.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…These animals were divided into four groups, 4 animals of nearly the same body weight to each group, and were designated as groups 1-4. The rabbits of each group were caged together, and 2 animals from each cage were given a daily oral dose of 16 mg/kg indomethacin per kilogram body weight [Boyle et a!., 1976]. The other 2 animals in each group were used as controls.…”

Section: Methodsmentioning

confidence: 99%

Effect of indomethacin on the histological structure and cholinesterase activity of taste buds

State¹,

Siraffy²,

Hamed³

et al. 1980

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The present work was undertaken to study the effect of indomethacin on the histological structure and cholinesterase activity of taste buds. 16 adult rabbits were divided into four groups; 2 animals of each group were given a daily oral dose of indomethacin and the other 2 animals were used as controls. The animals were sacrificed at 7, 12,17 and 30 days, respectively. The areas containing circumvallate and foliate papillae were excised for the study of their histological structure and cholinesterase activity. Administration of indomethacin was followed by a decrease in cholinesterase activity and a shrinkage of the reactive zones of the perigemmal, intragemmal and subgemmal plexuses; the cholinesterase activity eventually disappeared on the 17th day. On the 30th day, it reappeared in the above-mentioned sites. The taste buds did not show any degenerative changes and were similar to those of the controls. The significance of these findings is discussed.

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The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs

Cited by 67 publications

References 9 publications

A comparison of the anti-inflammatory effects of copper aspirinate and other copper salts in the rat and guinea pig

A comparison of the anti-inflammatory effects of copper aspirinate and other copper salts in the rat and guinea pig

Modulation of polymorphonuclear leukocyte responsiveness by copper (II)2 (niflumate)4

Effect of indomethacin on the histological structure and cholinesterase activity of taste buds

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