The Role of Corneal Innervation in LASIK-Induced Neuropathic Dry Eye

Chao, Cecilia; Golebiowski, Blanka; Stapleton, Fiona

doi:10.1016/j.jtos.2013.09.001

Cited by 140 publications

(134 citation statements)

References 131 publications

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“…8,9 Furthermore, studies have analyzed nerve regeneration in the SBNP as an indicator of corneal recovery following surgical refractive correction and other ocular surgery. [10][11][12] Hence, in vivo confocal microscopy of the SBNP has become an important technique for gauging the status of corneal innervation in the living human eye.…”

Section: Introductionmentioning

confidence: 99%

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change

Lum¹,

Golebiowski²,

Swarbrick³

2017

The Ocular Surface

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Section: Introductionmentioning

confidence: 99%

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change

Lum¹,

Golebiowski²,

Swarbrick³

2017

The Ocular Surface

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“…Various types of corneal epithelial disorders including PEDs have been found to result from insults to the trigeminal nerve and are known collectively as neurotrophic keratopathies (Belmonte et al, 2004a). Clinical causes of loss or impairment of trigeminal nerve function and reduced corneal sensation include herpes simplex virus or herpes zoster ophthalmicus virus infection (Cobo, 1988;Holland and Schwartz, 1999;Liesegang, 1985); complications of surgery for acoustic neurioma or trigeminal neuralgia (Blau et al, 1969;Rosenberg et al, 1981) or of ophthalmic surgeries such as penetrating keratoplasty, LASIK, and photorefractive keratectomy (Benitez-del-Castillo et al, 2001;Bragheeth and Dua, 2005;Campos et al, 1992;Chao et al, 2014;Chuck et al, 2000;Ishikawa et al, 1994;Kalyvianaki et al, 2006;Kohlhaas, 1998;Kumano et al, 2003;Lee et al, 2006;Linna et al, 2000;Mathers et al, 1988;Matsui et al, 2001;Melki and Azar, 2001;Nassaralla et al, 2003;Nejima et al, 2005;Rao et al, 1985;Stachs et al, 2010;Tugal Tutkun et al, 1993;Vestergaard et al, 2013;Wilson, 2001); thermal or chemical burns of the cornea; toxic keratopathy such as that resulting from abuse of topical anesthetics or bblockers (Chen et al, 2004;Rosenwasser, 1989;Spinelli et al, 1984;Van Buskirk, 1979;Willis and Laibson, 1970); contact lens wear; diabetes mellitus (Cousen et al, 2007;Davidson et al, 2012a,b;…”

Section: Clinical Basis For Study Of Substance Pmentioning

confidence: 99%

Peptide therapies for ocular surface disturbances based on fibronectin–integrin interactions

Nishida

Inui

Nomizu

2015

Progress in Retinal and Eye Research

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The condition of the corneal epithelium is a critical determinant of corneal transparency and clear vision. The corneal epithelium serves as a barrier to protect the eye from external insults, with its smooth surface being essential for its optical properties. Disorders of the corneal epithelium include superficial punctate keratopathy, corneal erosion, and persistent epithelial defects (PEDs). The prompt resolution of these disorders is important for minimization of further damage to the cornea. Currently available treatment modalities for corneal epithelial disorders are based on protection of the ocular surface in order to allow natural healing to proceed. PEDs remain among the most difficult corneal conditions to treat, however. On the basis of characterization of the pathobiology of PEDs at the cell and molecular biological levels, we have strived to develop new modes of treatment for these defects. These treatments rely on two key concepts: provision of a substrate, such as the adhesive glycoprotein fibronectin, for the attachment and migration of corneal epithelial cells, and activation of these cells by biological agents such as the combination of substance P and insulin-like growth factor-1 (IGF-1). Central to both approaches is the role of the fibronectin-integrin system in corneal epithelial wound healing. Determination of the minimum amino acid sequences required for the promotion of corneal epithelial wound closure by fibronectin (PHSRN) and by substance P (FGLM-amide) plus IGF-1 (SSSR) has led to the development of peptide eyedrops for the treatment of PEDs that are free of adverse effects of the parent molecules.

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“…The main proposed cause of dry eye after LASIK surgery is iatrogenic corneal nerve damage. During the procedure of the anterior stromal flap and excimer laser ablation of the cornea, both the dense sub-basal nerve plexus and stromal corneal nerves are disrupted [3]. Immediately after the procedure, patients present symptoms of dry eye syndrome, including dryness, burning sensation, stinging, photophobia, ocular discomfort, and even reduction of postoperative visual acuity [4].…”

Section: Introductionmentioning

confidence: 99%

Plasma Rich in Growth Factors for the Treatment of Dry Eye after LASIK Surgery

et al. 2018

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Purpose: The aim of this study was to evaluate the use of plasma rich in growth factors (PRGF) eye drops in patients with dry eye disease after laser-assisted in situ keratomileusis (LASIK) surgery. Material and Methods: This is a longitudinal, retrospective, comparative, and descriptive study of 77 eyes of 42 patients with dry eye disease following LASIK surgery. This study was designed to evaluate the efficacy of PRGF treatment compared to conventional therapy (control group). Outcome measures including signs and symptoms of dry eye disease were evaluated before and after treatment. The percentage of change before and after treatment for each clinical variable measured was compared between both groups. Results: There were 1–4 treatment cycles with PRGF eye drops (1 cycle = 6 weeks). Results showed a statistically significant improvement in the Ocular Surface Disease Index (38.12%), visual analogue scale scores for frequency (41.89%) and severity (42.47%), and the Schirmer test scores (88.98%) after PRGF treatment (p < 0.05). No adverse events were reported after PRGF treatment. Conclusions: These results suggest that PRGF eye drops are effective for the improvement of dry eye symptoms in patients who underwent LASIK surgery in comparison to the conventional therapy. The treatment with PRGF is an alternative for patients who suffer from postoperative dry eye.

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The Role of Corneal Innervation in LASIK-Induced Neuropathic Dry Eye

Cited by 140 publications

References 131 publications

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change

Changes in Corneal Subbasal Nerve Morphology and Sensitivity During Orthokeratology: Onset of Change

Peptide therapies for ocular surface disturbances based on fibronectin–integrin interactions

Plasma Rich in Growth Factors for the Treatment of Dry Eye after LASIK Surgery

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