It is an intriguing question of how people can reduce stress in which situations where internal moral standards are violated. Addressing this question, moral disengagement theory has been proposed to explain different cognitive mechanisms which ease people into engaging or witnessing moral transgressions. Several findings showed that moral disengagement tendencies might be explained by individual differences as well as contextual factors. Beyond showing the correlations between moral disengagement processes and individual differences and contextual factors, it is also valuable to investigate if there is an effective way to intervene in moral disengagement. This review article addresses the previously shown evidence regarding individual differences, contextual factors, and interventions, which in turn aim to enrich our understanding of the underlying psychological mechanisms to reduce unethical behaviors. Taken together, Honesty-Modesty, Agreeableness, Conscientiousness, Psychopathy, and Machiavellianism were found to be individual differences associated with moral disengagement. Additionally, less research yielded that attachment styles, political attitudes, moral identity, and moral emotions might be important to experience moral disengagement. Although several studies showed that individual differences are related to being more prone to moral disengagement, these studies had rarely been considered in intervention programs aiming to reduce immoral behaviors. Programs that have been designed to reduce moral disengagement overlook the long-term effects. Additionally, interventions often focus on the work environment and adolescence. In the future, interventions that include longitudinal designs considering the role of individual differences and different contexts might contribute to the relevant literature.