The Role of CT in the Staging and Follow-Up of Testicular Tumors: Baseline, Recurrence and Pitfalls

Pierre, Thibaut; Selhane, Fatine; Zareski, Élise; Garcia, Camilo; Fizazi, Karim; Loriot, Yohann; Patrikidou, Anna; Naoun, Natacha; Bernard‐Tessier, Alice; Lebâcle, C.; Blanchard, Pierre; Rocher, Laurence; Balleyguier, Corinne

doi:10.3390/cancers14163965

Cited by 8 publications

(2 citation statements)

References 69 publications

(82 reference statements)

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“…The staging of testicular tumors is based on the American Joint Committee on Cancer (AJCC) group. Stage IA tumors are described as limited neoplastic cells in the testicles without lymphovascular invasion and normal tumor marker levels [ 10 ]. Radical inguinal orchiectomy is curative in 75% of cases.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of a Non-seminomatous Testicular Cancer Metastasis to the Duodenum: A Case Report

Assi,

Awwad,

Baraghithi

et al. 2024

Cureus

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Testicular cancer is among the most common solid tumors in young men. Gastrointestinal tract (GIT) metastasis of testicular cancer has been rarely reported. In addition, metastasis occurs most commonly through retroperitoneal lymph nodes. Manifestations like abdominal pain and obstruction can be present if metastasis to GIT was considered. We report here a case of a 34-year-old male who was admitted to our GIT unit complaining of episodic epigastric pain. Computed Tomogram (CT) scan demonstrated a soft tissue like lesion involving the lumen of duodenum. Moreover, the patient had a right radical orchiectomy 18 months prior to the presentation due to a stage IA non-seminomatous germ cell tumor with no lymphovascular invasion and free surgical margins. Esophagogastroduodenoscopy (EGD) revealed a malignant appearing duodenal lesion and biopsy showed that it was compatible with germ cell tumor. Metastatic embryonal carcinoma to duodenum was diagnosed and confirmed by immunohistochemical stains. Then, the patient’s situation was discussed and decided to be on a plan of four cycles of chemotherapy regimens. Testicular malignancy metastasis to GIT is uncommon, but it’s important to know that there is a contact between GIT and testicular lymphatic drainage through para-aortic lymph nodes. So, even if it’s rare to occur, it’s still possible, and we should always be concerned about it. Mostly, diagnosis of testicular tumors begins with evaluating tumor markers such as alpha-fetoprotein (AFP), beta-subunit of human chorionic gonadotropin (B-hCG), and lactate dehydrogenase (LDH). But in contrast, all of these markers were within the normal range of their values in our case. Suspicion for metastasis and GIT involvement must be raised when dealing with a young male who had a history of testicular tumor such as embryonal carcinoma which was reported here in our case. That is very essential for avoiding potential complications and saving time in order to start management.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of a Non-seminomatous Testicular Cancer Metastasis to the Duodenum: A Case Report

Assi,

Awwad,

Baraghithi

et al. 2024

Cureus

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“…There are various important diagnostic values in diagnosing testicular cancer. Ultrasonography (US) is the most common first-line imaging modality in patients with suspected testicular cancer [7] , but it is not able to confidently distinguish between benign and malignant testicular masses [9][10][11] . Computed tomography (CT) imaging plays a crucial role in the initial staging of disease prior to orchidectomy [12] .…”

Section: Testicular Cancermentioning

confidence: 99%

The current use of artificial intelligence in testicular cancer: a systematic review

Chuluunbaatar,

Bansal,

Brodie

et al. 2023

Art Int Surg

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Testicular cancer is often overshadowed by other cancers despite being the most common cancer in men aged 15 to 34 years. This systematic review focuses on the potential of machine learning and deep learning techniques in the areas of testicular cancer imaging and histopathology, where artificial intelligence (AI) could assist in diagnosis, evaluation, and prognostication. Various studies have highlighted AI’s ability to accurately distinguish between benign and malignant lesions and characterisation within malignant lesions using magnetic resonance imaging (MRI) radiomics. Models have also been used in predicting histopathological findings to allow for greater accuracy and reproducibility. Further work is required to explore AI implementation in ultrasound imaging, which is the cheapest and most used modality.

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Single-cell RNA sequencing technology in human spermatogenesis: Progresses and perspectives

Jia,

Wang,

Zhou

et al. 2023

Mol Cell Biochem

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The Role of CT in the Staging and Follow-Up of Testicular Tumors: Baseline, Recurrence and Pitfalls

Cited by 8 publications

References 69 publications

A Rare Case of a Non-seminomatous Testicular Cancer Metastasis to the Duodenum: A Case Report

A Rare Case of a Non-seminomatous Testicular Cancer Metastasis to the Duodenum: A Case Report

The current use of artificial intelligence in testicular cancer: a systematic review

Single-cell RNA sequencing technology in human spermatogenesis: Progresses and perspectives

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