The Role of Curcumin in Post-Ischemic Brain

Abstract

Progressive accumulation of misfolded amyloid and tau protein in intracellular and extracellular spaces is the most crucial etiopathological feature of brain ischemia, synaptic damage, or neural communication impairment. Clinical data suggest that dietary intake of curcumin enhances neurogenesis and offers neuroprotection. Curcumin is a natural polyphenolic compound with diverse and attractive biological properties. It may prevent aging-associated changes in cellular proteins, such as β-amyloid peptide and tau protein, that lead to protein insolubility and aggregation after ischemic brain damage. Therefore, curcumin seems to be a promising supplementary agent against neurodegeneration development after brain ischemia. The aim of this chapter is to highlight our current understanding of the neuroprotective role of curcumin in cerebral ischemia-reperfusion injury. The limitations and adverse events of curcumin are also presented.

Effect of the Bioactive Compound Curcumin on Conditions After Ischemic Stroke: A Systematic Review

“…Curcumin is a bioactive compound with significant antiinflammatory, antiapoptotic, and antioxidant properties. This results in agree to previous studies stating curcumin as a traditional medicine has anti-infl ammatory, anti-infective, antitumor, antibacterial, and antioxidant properties, and is believed to have a positive effect on ischemic stroke (Goozee et al, 2016;Hagl et al, 2015;Manca et al, 2015;Park et al, 2021;Rusek & Czuczwar, 2021). The anti-inflammatory, antioxidant and neuroprotective properties contained in curcumin help control ischemic stroke by preventing more severe brain impact (Ułamek-Kozioł et al, 2020).…”

“…It has high antioxidant properties, anti-infl ammatory properties, anti-apoptosis, and is able to protect the blood brain barrier (BBB). In addition, many studies showed that curcumin plays role in promoting neurogenesis and as neuroprotection useful for repairing brain cells in ischemic stroke patients Li et al, 2015;Rusek & Czuczwar, 2021;Ułamek-Kozioł et al, 2020).…”

“…Ischemic stroke leads to many complications like memory loss, motor dysfunction, fatigue, mental state change, and Alzheimer (Béjot et al, 2016). In addition, the incidence of ischemic stroke is associated with continuous treatment, infl icting unfavorable consequences in terms of socio-economic to a country (Béjot et al, 2016;Rusek & Czuczwar, 2021). Death due to stroke in young adults are currently starting to increase significantly, especially in developing countries in which the incidence of stroke is indeed common (Feigin et al, 2017).…”