The role of cytokines in cardiac surgery

Tønnesen, Else; Christensen, Vibeke Brix; Toft, Palle

doi:10.1016/0167-5273(96)02568-5

Cited by 50 publications

(31 citation statements)

References 61 publications

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“…In particular, an uncontrolled and prolonged stimulation of polymorphonuclear cells, as occurs in clinical conditions such as respiratory distress syndrome, septicemia, postischemic organ reperfusion, and rheumatoid arthritis (4,18), can determine tissue damaging and multiorgan failure.…”

Section: Discussionmentioning

confidence: 99%

Monitoring of monocyte functional state after extracorporeal circulation: A flow cytometry study

Sbrana

Parri

Filippis

et al. 2004

Cytometry Part B Clinical

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Results: Cardiac surgery with CPB induced down-modulation of surface molecules expression on peripheral monocytes, especially at 24 h after CPB, for CD18, CD11a, and CD11b (P < 0.003) and for the CD15 adhesive cluster (P ‫؍‬ 0.0028) and HLA-DR (P < 0.001). At 4 h after CPB, downregulation was observed for CD14 (P ‫؍‬ 0.004), CD45 (P ‫؍‬ 0.014), and CD15 (P ‫؍‬ 0.0056). A loss of MPO was detected in venous peripheral (at 24 h after CPB, P ‫؍‬ 0.01) or coronary (at reperfusion, P < 0.02) blood. The CD15 cluster complex exhibited a down-modulation in coronary blood (at reperfusion, P ‫؍‬ 0.0003). Spontaneous intracellular production of IL-1␤, IL-6, and IL-8 decreased at 24 h after CPB (P < 0.05).Conclusions: The down-modulation of integrins and adhesive receptor expression and the loss of MPO suggest a strong activation and shedding reaction of circulating monocyte after CPB, further exacerbated by contact with coronary ischemic vessels. The changes of differentiation antigens may reflect the appearance of a partially immature population immediately after CPB. The reduced proinflammatory cytokine production, observed at 24 h after CPB, suggests a functional polarization of circulating monocytes.

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Section: Discussionmentioning

confidence: 99%

Monitoring of monocyte functional state after extracorporeal circulation: A flow cytometry study

Sbrana

Parri

Filippis

et al. 2004

Cytometry Part B Clinical

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“…29 This interleukin, classified as a proinflammatory cytokine, is associated with the diffuse inflammatory response that arises from CPB. 30 Aortic postclamping followed by reperfusion after release of the cross-clamp is often used for CPB. Recent data demonstrate that this reperfusion accelerates the synthesis and the release of IL-6 in the absence of endotoxin.…”

Section: Discussionmentioning

confidence: 99%

Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides

Tasiemski

Hammad

Vandenbulcke

et al. 2002

Blood

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Chromogranin A (CGA) and chromogranin B (CGB) are acidic proteins stored in secretory organelles of endocrine cells and neurons. In addition to their roles as helper proteins in the packaging of pep-tides, they may serve as prohormones to generate biologically active peptides such as vasostatin-1 and secretolytin. These molecules derived from CGA and CGB, respectively, possess antimicrobial properties. The present study demonstrates that plasmatic levels of both vasostatin-1 and secretolytin increase during surgery in patients undergoing cardiopulmonary bypass (CPB). Vasostatin-1 and secretoly-tin, initially present in plasma at low levels , are released just after skin incision. Consequently, they can be added to enk-elytin, an antibacterial peptide derived from proenkephalin A, for the panoply of components acting as a first protective barrier against hypothetical invasion of pathogens, which may occur during surgery. CGA and CGB, more commonly viewed as markers for endocrine and neuronal cells, were also found to have an immune origin. RNA messengers coding for CGB were amplified by reverse transcription-polymerase chain reaction in human monocytes, and immunocyto-chemical analysis by confocal micros-copy revealed the presence of CGA or CGB or both in monocytes and neutro-phils. A combination of techniques including confocal microscopic analysis, mass spectrometry measurement, and antibac-terial tests allowed for the identification of the positive role of interleukin 6 (IL-6) in the secretolytin release from mono-cytes in vitro. Because IL-6 release is known to be strongly enhanced during CPB, we suggest a possible relationship between IL-6 and the increased level of secretolytin in patients undergoing CPB. (Blood. 2002;100:553-559)

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“…Ein Überwiegen der proinflammatorischen Zytokine, z.B. durch die Einschwemmung von Endotoxin bei Sepsis oder bei schwerem Trauma, bewirkt eine Reihe von Symptomen wie Fieber, Schläfrigkeit, Kachexie bis hin zu Hypotension, Gerinnungsstörungen und Schock [46]. Die Produktion proinflammatorischer Zytokine wird durch die Wirkung von Anästhetika beeinflußt [6,28,38,40,43].…”

Section: Introductionunclassified

Zytokinfreisetzung und Verteilung mononukleärer Zellen im peripheren Blut unter dem Einfluß der Allgemeinnarkose

et al. 1998

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The role of cytokines in cardiac surgery

Cited by 50 publications

References 61 publications

Monitoring of monocyte functional state after extracorporeal circulation: A flow cytometry study

Monitoring of monocyte functional state after extracorporeal circulation: A flow cytometry study

Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides

Zytokinfreisetzung und Verteilung mononukleärer Zellen im peripheren Blut unter dem Einfluß der Allgemeinnarkose

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