The role of deubiquitinating enzymes in gastric cancer (Review)

Sun, Jianfang; Shi, Xiaojing; Mamun, M. A. A.; Gao, Yongshun

doi:10.3892/ol.2019.11062

Cited by 19 publications

(18 citation statements)

References 141 publications

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“…Therefore, USP43 may provide a potential target for the treatment of CRC. Recent reports indicated that the abnormal expression of USP43 in CRC and breast cancer tissues is associated with a poorer prognosis [14,29]. Those results are consistent with our study.…”

Section: Discussionsupporting

confidence: 94%

USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer

Ye¹,

Wang²,

Huang³

et al. 2021

J. Cancer

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Colorectal cancer is one of the most common malignant tumors of the digestive tract. In this study, we had examined the biological role of USP43 in colorectal cancer. USP43 protein and mRNA abundance in clinical tissues and five cell lines were analyzed with quantitative real-time PCR test (qRT-PCR) and western blot. USP43 overexpression treated DLD1 cells and USP43 knockdown treated SW480 cells were used to study cell proliferation, migration, colony formation, invasion, and the expression of epithelial-mesenchymal transformation (EMT) biomarkers. Moreover, ubiquitination related ZEB1 degradation was studied with qRT-PCR and western blot. The relationships between USP43 and ZEB1 were investigated with western blot, co-immunoprecipitation, migration, and invasion. USP43 was highly expressed in colorectal cancer tissues. USP43 overexpression and knockdown treatments could affect cell proliferation, colony formation, migration, invasion, and the expression of EMT associated biomarkers. Moreover, USP43 can regulate ZEB1 degradation through ubiquitination pathway. USP43 could promote the proliferation, migration, and invasion of colorectal cancer. Meanwhile, USP43 can deubiquitinate and stabilize the ZEB1 protein, which plays an important role in the function of colorectal cancer.

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Section: Discussionsupporting

confidence: 94%

USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer

Ye¹,

Wang²,

Huang³

et al. 2021

J. Cancer

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“…The human genome encodes approximately 103 DUBs which divided into six families: ubiquitin-specific proteases (USPs), Josephins and JAB1/MPN/MOV34 metalloenzymes, ubiquitin C-terminal hydrolases (UCHs), motif interacting with Ub-containing novel DUB family (MINDY) and ovarian tumour proteases (OTUs). 43 Analysis of purified CoV PLPs and the X-ray crystal structure of SCoV PLpro reveal new information on viral DUB activity. 44 There is evidence for the structural relationship between SCoV PLpro and ubiquitin C-terminal hydrolase (UCH-L1), ubiquitin-specific protease 14 (USP14) and herpes-associated ubiquitin-specific protease (HAUSP or USP7).…”

Section: Dubs and Deisgylatingmentioning

confidence: 99%

“…The DUBs, a large group of cysteine proteases, cleave ubiquitin or ubiquitin‐like proteins from proteins and other substrates. The human genome encodes approximately 103 DUBs which divided into six families: ubiquitin‐specific proteases (USPs), Josephins and JAB1/MPN/MOV34 metalloenzymes, ubiquitin C‐terminal hydrolases (UCHs), motif interacting with Ub‐containing novel DUB family (MINDY) and ovarian tumour proteases (OTUs) 43 …”

Section: Dubs and Deisgylatingmentioning

confidence: 99%

Interactions between SARS coronavirus 2 papain‐like protease and immune system: A potential drug target for the treatment of COVID‐19

Mahmoudvand

Shokri

2021

Scand J Immunol

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The innate immune system is the first line of defence against viral infection and characterized by production of type I interferons (IFN-α and β). 1 Antiviral response relies on pattern-recognition receptors (PRRs) of the innate immune system which recognize pathogen-associated molecular patterns (PAMPs). 2 The response is initiated by cytoplasmic protein sensors such as RIG-I (retinoic acid-inducible gene I), melanoma differentiation-associated protein 5 (MDA5) and membrane sensors as toll-like receptors (TLR3, 7, 8 and 9). 3 Type I IFNs induce the activation of signal transducer and activator of transcription (STAT) factors that induce the expression of hundreds of IFN-stimulated genes (ISGs) which act as antiviral effectors to control viral replication and spread. 4 Many viruses encode proteins that antagonize both the innate and adapted arms of the immune response. 5 All CoVs encode at least one papain-like protease (PLpro) with deubiquitinating (DUB), deISGylating (deISG) and other activities that elicit the appropriate innate immune response. 6 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) recently entered the human population at the end of 2019 from Hunnan seafood market in Wuhan, China. 7 The virus causes a pandemic infection in more than 119 million people with a case fatality ratio (CFR) of 1.4% with substantially higher ratios in older age groups, 0.32% in those aged <60 years, 6.4% in those aged ≥60 years and up to 13.4% in those aged 80 years or older. 8,9 This raises an urgent need to develop an effective treatment based on identifying targets for viral factors which blocked or reduced innate immune responses. A majority of the newly reported studies showed that PLpro,

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“…Deubiquitination is the reverse reaction of ubiquitination, is mediated by multiple deubiquitinases, which are responsible for removing ubiquitin from the substrates, and plays a vital role in the regulation of protein stability, activity, and its subcellular localization (Farshi, 2015;Reyes-Turcu et al, 2009;Sun, Liu, et al, 2020). So far, there has been about 80 deubiqutinases identified and mainly classified in 5 distinct families, including ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), ovarian tumor proteases (OTUs), Machado-Joseph disease (MJD) protein domain proteases, and JAMM motif zinc metalloproteases (Sun, Shi, et al, 2020;Young et al, 2019). Similar to ubiquitination, deubiquitination regulates various cellular processes, including DNA damage response, cell cycle, apoptosis, DNA replication, and tumorigenesis (Brinkmann et al, 2015).…”

Section: The Ubiquitination and Deubiquitination In Atr-chk1 Signaling Pathwaymentioning

confidence: 99%

The post translational modification of key regulators of ATR signaling in DNA replication

Chen

Yuan

2021

GENOME INSTAB. DIS.

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DNA replication is one of the most critical psychological process, which mainly consists of three steps: initiation, elongation, and termination. Precise regulation through all stages of DNA replication is essential for maintaining genome integrity in proliferating cells. During each cell cycle, the complete genetic information existing in the DNA needs to be duplicated and passed on to the daughter cells. The DNA replication machinery is confronted with many challenges and stresses owing to endogenous and exogenous facts that could harm the faithful duplication of the DNA. The abnormality of DNA replication could cause genomic instability and tumorigenesis. ATR is a master regulator of cells in response to DNA replication stress to safeguard genomic stability and prevent tumorigenesis. In the past years, the key functions of post-translational modification (PTM) in ATR signaling transduction has been explored. ATR signaling is complicatedly and tightly regulated by multiple PTMs, such as phosphorylation, acetylation, ubiquitination, SUMOylation and so on. Here, we summarize how the ATR signaling pathway is tightly regulated by PTM. Furthermore, we describe the critical roles of ATR signaling in DNA replication and safeguarding genomic stability. In the past years, the key functions of post-translational modification (PTM) in DNA replication has been explored. These findings benefit for us better understand the complicated mechanism of DNA replication signaling pathway.

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The role of deubiquitinating enzymes in gastric cancer (Review)

Cited by 19 publications

References 141 publications

USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer

USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer

Interactions between SARS coronavirus 2 papain‐like protease and immune system: A potential drug target for the treatment of COVID‐19

The post translational modification of key regulators of ATR signaling in DNA replication

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