The Role of Diet in Regulation of Macrophages Functioning

Varaeva, Y.; Kirichenko, Tatiana V.; Шапошникова, Н. Н.; Nikityuk, D. B.; Starodubova, A. V.

doi:10.3390/biomedicines10092087

Cited by 6 publications

(1 citation statement)

References 109 publications

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“…Other groups have investigated ways of increasing myeloid function. For example, diet has been suggested as a means of increasing myeloid function ( 106 ). More developed as a locus for drug development are receptors and cell signaling pathways known to regulate myeloid cell function.…”

Section: Other Approaches To Increase the Immune Responsementioning

confidence: 99%

Classical and nonclassical effects of angiotensin-converting enzyme: How increased ACE enhances myeloid immune function

Bernstein,

Cao,

Shibata

et al. 2024

Journal of Biological Chemistry

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Section: Other Approaches To Increase the Immune Responsementioning

confidence: 99%

Classical and nonclassical effects of angiotensin-converting enzyme: How increased ACE enhances myeloid immune function

Bernstein,

Cao,

Shibata

et al. 2024

Journal of Biological Chemistry

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Innate immunity champions: The diverse functions of macrophages

Biscu,

Zouzaf,

Cicia

et al. 2024

Eur J Immunol

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Macrophages are instrumental in maintaining tissue homeostasis, modulating inflammation, and driving regeneration. The advent of omics techniques has led to the identification of numerous tissue‐specific macrophage subtypes, thereby introducing the concept of the “macrophage niche”. This paradigm underscores the ability of macrophages to adapt their functions based on environmental cues, such as tissue‐specific signals. This adaptability is closely linked to their metabolic states, which are crucial for their function and role in health and disease. Macrophage metabolism is central to their ability to switch between proinflammatory and anti‐inflammatory states. In this regard, environmental factors, including the extracellular matrix, cellular interactions, and microbial metabolites, profoundly influence macrophage behavior. Moreover, diet and gut microbiota significantly impact macrophage function, with nutrients and microbial metabolites influencing their activity and contributing to conditions like inflammatory bowel disease. Targeting specific macrophage functions and their metabolic processes is leading to the development of novel treatments for a range of chronic inflammatory conditions. The exploration of macrophage biology enriches our understanding of immune regulation and holds the promise of innovative approaches to managing diseases marked by inflammation and immune dysfunction, offering a frontier for scientific and clinical advancement.

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Macrophage polarization and metabolic reprogramming in abdominal aortic aneurysm

Hou,

Zhou,

et al. 2024

Immunity Inflam & Disease

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BackgroundAbdominal aortic aneurysm (AAA) is a macrovascular disease with high morbidity and mortality in the elderly. The limitation of the current management is that most patients can only be followed up until the AAA diameter increases to a threshold, and surgical intervention is recommended. The development of preventive and curative drugs for AAA is urgently needed. Macrophage‐mediated immune inflammation is one of the key pathological links in the occurrence and development of AAA.AimsThis review article aims to evaluate the impact of immunometabolism on macrophage biology and its role in AAA.MethodsWe analyze publications focusing on the polarization and metabolic reprogramming in macrophages as well as their potential impact on AAA, and summarize the potential interventions that are currently available to regulate these processes.ResultsThe phenotypic and functional changes in macrophages are accompanied by significant alterations in metabolic pathways. The interaction between macrophage polarization and metabolic pathways significantly influences the progression of AAA.ConclusionMacrophage polarization is a manifestation of the gross dichotomy of macrophage function into pro‐inflammatory killing and tissue repair, that is, classically activated M1 macrophages and alternatively activated M2 macrophages. Macrophage functions are closely linked to metabolic changes, and the emerging field of immunometabolism is providing unique insights into the role of macrophages in AAA. It is essential to further investigate the precise metabolic changes and their functional consequences in AAA‐associated macrophages.

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The Role of Diet in Regulation of Macrophages Functioning

Cited by 6 publications

References 109 publications

Classical and nonclassical effects of angiotensin-converting enzyme: How increased ACE enhances myeloid immune function

Classical and nonclassical effects of angiotensin-converting enzyme: How increased ACE enhances myeloid immune function

Innate immunity champions: The diverse functions of macrophages

Macrophage polarization and metabolic reprogramming in abdominal aortic aneurysm

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