The role of diet in triggering human inflammatory disorders in the modern age

Huang, Edmond Y.; Devkota, Suzanne; Moscoso, Dagmara I.; Chang, Eugene B.; Leone, Vanessa

doi:10.1016/j.micinf.2013.07.004

Cited by 39 publications

(28 citation statements)

References 70 publications

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“…Much of today’s food supply has been processed, modified, stored and transported great distances, in contrast to the traditional diet, where food that was produced locally was consumed shortly after harvest. This shift to the Western diet pattern is hypothesized to increase pro-inflammatory cytokines, modulate intestinal permeability, and alter the intestinal microbiota promoting a low-grade chronic inflammation in the gut [73]. A diet that contains pro-inflammatory foods is an important risk factor in the development of UC.…”

Section: Diet In the Etiology Of Ibdmentioning

confidence: 99%

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

Haskey

Gibson

2017

Nutrients

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Diet has been speculated to be a factor in the pathogenesis of inflammatory bowel disease and may be an important factor in managing disease symptoms. Patients manipulate their diet in attempt to control symptoms, often leading to the adoption of inappropriately restrictive diets, which places them at risk for nutritional complications. Health professionals struggle to provide evidence-based nutrition guidance to patients due to an overall lack of uniformity or clarity amongst research studies. Well-designed diet studies are urgently needed to create an enhanced understanding of the role diet plays in the management of inflammatory bowel disease. The aim of this review is to summarize the current data available on dietary management of inflammatory bowel disease and to demonstrate that dietary modulation may be an important consideration in managing disease. By addressing the relevance of diet in inflammatory bowel disease, health professionals are able to better support patients and collaborate with dietitians to improve nutrition therapy.

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Section: Diet In the Etiology Of Ibdmentioning

confidence: 99%

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

Haskey

Gibson

2017

Nutrients

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“…Considerable evidence strongly suggests that dietary intake, particularly a shift to a westernized diet, contributes to development and progression of diseases such as obesity, metabolic liver disorders, rheumatoid arthritis, and inflammatory bowel disease (Huang et al. 2013). Many factors influence the composition of the intestinal microbiome including dietary components such as lipid and carbohydrate, as well as medical compounds that increase or decrease the survival and growth of specific types of bacteria.…”

Section: Introductionmentioning

confidence: 99%

Daikenchuto (TU‐100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K

Hasebe

Ueno

Musch

et al. 2016

Pharmacology Res & Perspec

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Many pharmaceutical agents not only require microbial metabolism for increased bioavailability and bioactivity, but also have direct effects on gut microbial assemblage and function. We examined the possibility that these actions are not mutually exclusive and may be mutually reinforcing in ways that enhance long‐term of these agents. Daikenchuto, TU‐100, is a traditional Japanese medicine containing ginseng. Conversion of the ginsenoside Rb1 (Rb1) to bioactive compound K (CK) requires bacterial metabolism. Diet‐incorporated TU‐100 was administered to mice over a period of several weeks. T‐RFLP and 454 pyrosequencing were performed to analyze the time‐dependent effects on fecal microbial membership. Fecal microbial capacity to metabolize Rb1 to CK was measured by adding TU‐100 or ginseng to stool samples to assess the generation of bioactive metabolites. Levels of metabolized TU‐100 components in plasma and in stool samples were measured by LC‐MS/MS. Cecal and stool short‐chain fatty acids were measured by GC‐MS. Dietary administration of TU‐100 for 28 days altered the gut microbiota, increasing several bacteria genera including members of Clostridia and Lactococcus lactis. Progressive capacity of microbiota to convert Rb1 to CK was observed over the 28 days administration of dietary TU‐100. Concomitantly with these changes, increases in all SCFA were observed in cecal contents and in acetate and butyrate content of the stool. Chronic consumption of dietary TU‐100 promotes changes in gut microbiota enhancing metabolic capacity of TU‐100 and increased bioavailability. We believe these findings have broad implications in optimizing the efficacy of natural compounds that depend on microbial bioconversion in general.

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“…Thus, the MedDiet has shown favorable effects on the incidence of MetS, plasma lipoprotein concentrations, endothelium vasodilatation, insulin resistance, and antioxidant capacity, as well as cardiovascular and cancer morbidity and mortality [38,39]. On the other hand, the Western diet has been positively associated with low-grade inflammation and contributes to an increased incidence of inflammatory diseases such as T2D, rheumatoid arthritis, inflammatory bowel disease and obesity, among others [40].…”

Section: Inflammation and Dietary Patternsmentioning

confidence: 99%

Dietary Patterns, Foods, Nutrients and Chronic Inflammatory Disorders

Casas¹,

Estruch²

2016

Immunome Res

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The World Health Organization (WHO) recognizes that diet plays an important role in the prevention of several non-infectious diseases. Unhealthy diets that include high intake of red and processed meat, sweets and desserts, potatoes, French fries, and refined grains) is associated with high plasma inflammatory biomarkers and a greater risk of cardiovascular disease (CVD), type 2 diabetes (T2D), cancer and other chronic diseases. On the other hand, prudent dietary patterns such as Mediterranean diet as well as intake of fruit, vegetables, extra virgin olive oil, walnuts, legumes, whole grains, fish, cocoa, coffee, tea and wine is associated with a reduced plasma inflammatory biomarkers and a lower risk of CVD, T2D and other chronic diseases. In respect to nutrients, excessive intake of carbohydrates, saturated fat, trans-fatty acids, and omega-6 polyunsaturated fatty acids (PUFA) may activate the innate immune system, leading to an excessive production of pro inflammatory cytokines associated with a reduced synthesis of anti-inflammatory cytokines. On the other hand, omega-3 PUFA, vitamin E and polyphenols could counter the effects of several inflammatory markers, decreasing, for example, the secretion of circulating and cellular factors involved in the atherosclerotic process.This review explains how healthy dietary patterns, foods and nutrients can reduce chronic inflammatory processes related to CVD, T2D, obesity or cancer and therefore be a good tool to prevent the development of these disorders.

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The role of diet in triggering human inflammatory disorders in the modern age

Cited by 39 publications

References 70 publications

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

Daikenchuto (TU‐100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K

Dietary Patterns, Foods, Nutrients and Chronic Inflammatory Disorders

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