The role of different fetal pulmonary artery Doppler indices in the prediction of neonatal respiratory distress syndrome

Khalil, Osama; Ghany, Hosny Abdel; Osman, Nasr Mohamed M.; Abdel‐Hamid, Mohamed

doi:10.21608/mjmr.2022.221988

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…As the main imaging examination method of NRDS, chest X-ray has the advantages of simple operation and convenient use, but it lacks specificity in the early stage. In addition, it is easy for clinicians to have errors in judging the condition [ 23 ]. Moreover, X-ray examination has ionizing radiation and newborns are particularly sensitive to it.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, X-ray examination has ionizing radiation and newborns are particularly sensitive to it. In order to understand the recovery of the lungs, chest X-ray examination is often needed, which will inevitably lead to high ionizing radiation damage due to many times of X-ray examination [ 23 , 24 ]. Therefore, there is an urgent need for efficient, convenient, and safe examination methods to study the pulmonary condition of NRDS infants [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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The Role and Clinical Value of Optimized Fetal Main Pulmonary Artery Doppler Parameters in the Diagnosis and Prognosis Monitoring of Neonatal Respiratory Distress Syndrome

Zhang

2022

Computational and Mathematical Methods in Medicine

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Objective. A retrospective study was conducted to explore the role and clinical value of optimized fetal main pulmonary artery Doppler parameters in the diagnosis and prognosis monitoring of neonatal respiratory distress syndrome (NRDS). Methods. Pregnant women admitted to our hospital for delivery from March 2019 to June 2021 were included in the study. There were 372 singleton pregnant women who voluntarily underwent ultrasound and Doppler examinations with informed consent for the study. The AT/ET ratio of the middle segment of the main pulmonary artery, the middle part of the left (or right) pulmonary artery, and the proximal segment of the intrapulmonary artery was measured by ultrasonic Doppler. According to the outcome of the newborn, it was divided into NRDS group ( n =90) and non-NRDS group ( n =282) to compare the differences of fetal AT/ET ratio at three Doppler sampling locations and the differences of fetal AT/ET ratio in different gestational weeks. Using Pearson’s correlation analysis, the correlation among the Doppler parameters of fetal main pulmonary artery, the ratio of AT and AT/ET, gestational weeks, and the efficiency of prenatal prediction of NRDS was evaluated by receiver-operating characteristic (ROC). In addition, the diagnostic efficiency of fetal main pulmonary artery Doppler parameter AT/ET ratio and amniotic fluid method for prenatal prediction of NRDS was compared. Results. Compared with the non-NRDS group, the gestational age, gestational age at delivery, and birth weight in the NRDS group were significantly lower than those in the non-NRDS group. The 1 min Apgar score of newborns was less than 7, and the proportion of newborns transferred to NICU was significantly higher than that in the control group. Compared with non-NRDS group, AT was significantly shortened, AT/ET ratio was significantly decreased, and ET was significantly prolonged in NRDS group. The fetal aortic blood flow parameters AT, ET, and AT/ET ratio in different gestational weeks were significantly different among the three groups. The AT/ET ratio in the middle segment of the aorta in NRDS group was lower than that in non-NRDS group. The ratio of AT/ET was still correlated with the occurrence of postpartum NRDS. The AUC value of NRDS predicted by AT/ET ratio was 0.984. In the combined determination of amniotic fluid Lh and S ratio and PG, the diagnostic accuracy of prenatal prediction of neonatal respiratory distress syndrome was 100.005%, 98.43%, and 95.56%, respectively. The accuracy of fetal aortic AT/ET ratio in prenatal prediction of neonatal respiratory distress syndrome was 100.005%, 95.28%, and 95.57%, respectively. The order of Kappa coefficient from high to low was amniotic fluid PG/L/S ratio, fetal main pulmonary artery blood flow parameter AT/ET ratio, amniotic fluid L/S ratio, OD650, amniotic fluid PG, and foam test. Conclusion. Fetal main pulmonary artery Doppler AT/ET ratio may be a very potential parameter for prenatal noninvasive prediction of NRDS. The fetal main pulmonary artery Doppler flow spectrum may be a very potential alternative to amniocentesis to evaluate FLM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Role and Clinical Value of Optimized Fetal Main Pulmonary Artery Doppler Parameters in the Diagnosis and Prognosis Monitoring of Neonatal Respiratory Distress Syndrome

Zhang

2022

Computational and Mathematical Methods in Medicine

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“…Between PI and RI, there was no statistically significant difference. Using a threshold of 0.3 for At/Et, the existence of RDS was predicted (sensitivity: 77.78 percent , specificity: 83.87 percent) [14]. Elkhalik and his colleague found that 46 (23%) of the fetuses had RDS (+ve) whereas 154 (77%) did not (-ve).…”

Section: Fig (1) Incidence Of Rds and Nicu Admission In All Studied C...mentioning

confidence: 99%

Evaluation of Fetal Lung Maturity Correlated by Various Ultrasound Parameters as Noninvasive Method

El Sheikh,

Tawfiq,

Fazaa

2023

Benha Journal of Applied Sciences

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Background: Neonatal respiratory distress syndrome (RDS) continues to be a major problem in perinatology, contributing to the morbidity and death of preterm babies. To lower the risk of newborn RDS, the major objective of this study was to measure fetal lung maturity utilizing various color Doppler and multiple ultrasonography characteristics. Methods: This research was conducted on a cohort of 100 pregnant women who gave birth at Benha University Hospitals between February 26, 2022 and August 25, 2022, spanning six months. According to the occurrence of RDS, we categorized our study subjects into two groups: Group RDS+: n = 13; group RDS-: n = 87. Regarding (Maternal age, Parity, Type of delivery), there was no statistically significant difference between the two groups, but there was a statistically significant difference between the two groups regarding (Gestational age at Birth and NBW). Results: According to ultrasonography measurements, the Mann-Whitney test revealed no significant changes in the main pulmonary artery diameter (MPA), trans cerebellar diameter, or placental thickness between the study groups. The chi-square test revealed significant differences between proximal tibial epiphysis and thalamic echogenicity (p 0.001). Positive PTE results were seen in 91.95 percent of the non-RDS group compared to 7.69 percent of the RDS group. Thalamic echogenicity was seen in 88.5% of the non-RDS group compared to 15.38% of the RDS group. Conclusions: The development of newborn RDS may be accurately predicted using certain acoustic characteristics. The ultrasonic identification of the proximal tibial ossification sites and thalamic echogenicity demonstrated the highest accuracy in predicting fetal lung maturity.

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Association of maternal serum vitamin D level with fetal pulmonary artery Doppler indices and neonatal respiratory distress syndrome

Amjadi,

Pooransari,

Mirzamoradi

et al. 2024

J of Clinical Ultrasound

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PurposeRespiratory distress syndrome (RDS) is potentially fatal in infants. The present study investigated the association of maternal serum vitamin D level with fetal pulmonary artery Doppler indices and neonatal RDS.MethodsThis cross‐sectional‐analytical study was conducted on 260 mothers admitted for delivery. The maternal serum 25‐hydroxyvitamin D level was measured and fetal main pulmonary artery Doppler indices were evaluated. The neonate's weight, apgar score, RDS, Umbilical cord arterial pH and neonatal intensive care unit admission were recorded.ResultsThere was a significant relationship between RDS and the low level of vitamin D in the mother's serum. Mothers with low vitamin D had higher fetal pulmonary artery pulsatility index (PI) and peak systolic velocity (PSV) and lower acceleration time (AT) to ejection time (ET) ratio. Also, in neonates with RDS, pulmonary artery PI was higher, and PSV and the ratio of AT to ET were significantly lower than neonates without RDS. Neonates with lower one and 5‐min apgar scores were born from mothers with lower vitamin D levels.ConclusionSerum levels of vitamin D in pregnant mothers as well as fetal pulmonary artery Doppler indices are correlated to RDS. There is a significant relationship between the serum level of vitamin D in pregnant mothers and fetal pulmonary artery Doppler indices.

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The role of different fetal pulmonary artery Doppler indices in the prediction of neonatal respiratory distress syndrome

Cited by 3 publications

References 4 publications

The Role and Clinical Value of Optimized Fetal Main Pulmonary Artery Doppler Parameters in the Diagnosis and Prognosis Monitoring of Neonatal Respiratory Distress Syndrome

The Role and Clinical Value of Optimized Fetal Main Pulmonary Artery Doppler Parameters in the Diagnosis and Prognosis Monitoring of Neonatal Respiratory Distress Syndrome

Evaluation of Fetal Lung Maturity Correlated by Various Ultrasound Parameters as Noninvasive Method

Association of maternal serum vitamin D level with fetal pulmonary artery Doppler indices and neonatal respiratory distress syndrome

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