The Role of Dynamic Histone Modifications in Learning Behavior

Fischer, André

doi:10.1007/7854_2019_108

Cited by 5 publications

(2 citation statements)

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“…Histone PTMs in general, and histone acetylation in particular, have received extensive attention in studies of memory formation over the past 15 years and have been extensively reviewed elsewhere [ 102 ], so we will only touch on it briefly. The emerging consensus is that histone modifications are rapidly induced during memory consolidation and return to baseline levels thereafter, thus playing a temporally-restricted role compared to DNA methylation [ 103 ].…”

Section: A Brief Review Of Epigenetic Modificationsmentioning

confidence: 99%

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

Creighton

Stefanelli

Reda

et al. 2020

IJMS

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The neuronal epigenome is highly sensitive to external events and its function is vital for producing stable behavioral outcomes, such as the formation of long-lasting memories. The importance of epigenetic regulation in memory is now well established and growing evidence points to altered epigenome function in the aging brain as a contributing factor to age-related memory decline. In this review, we first summarize the typical role of epigenetic factors in memory processing in a healthy young brain, then discuss the aspects of this system that are altered with aging. There is general agreement that many epigenetic marks are modified with aging, but there are still substantial inconsistencies in the precise nature of these changes and their link with memory decline. Here, we discuss the potential source of age-related changes in the epigenome and their implications for therapeutic intervention in age-related cognitive decline.

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Section: A Brief Review Of Epigenetic Modificationsmentioning

confidence: 99%

Epigenetic Mechanisms of Learning and Memory: Implications for Aging

Creighton

Stefanelli

Reda

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…1 ). As such, the study of behavioral epigenetics has impacted multiple fields broadly related to experience-dependent learning processes in the brain, including those for understanding stress and anxiety (e.g., reviewed in ( Kwapis and Wood, 2014 ; Kim et al, 2018 ), drug addiction (e.g., Rogge and Wood, 2013 ; López and Wood, 2015 ; Mews and Calipari, 2017 ), including habit formation and relapse ( Malvaez et al, 2018 ; Pribut et al, 2021 ; reviewed in Werner et al, 2021 ), as well as for understanding fundamental memory processes like its formation (e.g., Levenson and Sweatt, 2005 ; Oliveira, 2016 ; Woldemichael et al, 2014 ), extinction (e.g., Malvaez et al, 2013 ; reviewed in Marshall and Bredy, 2019 ), reconsolidation, forgetting or extinction ( Hemstedt et al, 2017 ; Hitchcock et al, 2018 ; Stafford and Lattal, 2011 ; Lattal and Wood, 2013 ), the distinction between recent versus remote memories ( Gräff et al, 2014 ; Parrish et al, 2010 ; Day and Sweatt, 2011 ; White and Wood, 2014 ; Zovkic and Sweatt, 2013 ; Jarome and Lubin, 2014 ), and for different types of memory (e.g., pain, Rahn et al, 2013 ; aversive, Kwapis and Wood, 2014 ; appetitive, Tuesta and Zhang, 2014 ) and memory disease (e.g., Fischer, 2019 ). Recent literature suggests that the impact of epigenetic processes on learning and memory extends to the sensory systems.…”

Section: Introductionmentioning

confidence: 99%