The role of E-cadherin and β-catenin in laryngeal cancer

Abstract

Epithelial cadherins with catenins form the E-cadherin-catenin complex that acts on cell-to-cell adhesion. The loss of these complex lead to the reduction or absence of epithelial cadherin expression in the cell membrane, cytoplasmic accumulation of β-catenin and its translocation to the nucleus, contributing to carcinogenic events. The objective of this study was to evaluate the expression of epithelial cadherin and β-catenin in patients with laryngeal tumor. A retrospective study of 52 patients with glottic or supraglottic squamous cell carcinoma was conducted and evaluated according to the tumor site, histological differentiation, TNM stage, survival analysis and compared with the immunohistochemical expression of epithelial cadherin and β-catenin. We observed statistically significant association between the epithelial cadherin expression reduction and supraglottic localization of the lesion, the presence of cervical metastasis, poorly differentiated tumors and locally advanced tumors when in glottic topography. Related to the expression of β-catenin, statistical significance was also found to the presence of cervical metastasis and tumor of low differentiation with the decreased expression of this marker. Regarding survival analysis, the low expression of β-catenin is related to worse overall survival and the reduction of expression of both markers to worse disease-free survival. We concluded that the reduction in expression of the markers studied leads to a prognostic impact as they are related to tumors with greater local aggressiveness and presence of cervical metastasis.

Syzygium cumini extract induced reactive oxygen species‐mediated apoptosis in human oral squamous carcinoma cells

“…Cadherin‐1 (CDH1) or E‐cadherin is a single‐pass transmembrane protein that mediates homophilic cell‐cell interactions . Tumor progression is often associated with the functional loss of cadherin‐1 and the transition to a more motile and invasive phenotype . Further, cadherin‐1 also plays several roles in apoptosis progression .…”

“…28 Tumor progression is often associated with the functional loss of cadherin-1 and the transition to a more motile and invasive phenotype. 28,29 Further, cadherin-1 also plays several roles in apoptosis progression. 30 In this study, S. cumini treatments caused significant upregulation of CDH1 protein and gene expressions.…”

Overview on Molecular Biomarkers for Laryngeal Cancer: Looking for New Answers to an Old Problem

“…A similar observation was reported by Nardi et al who evaluated by IHC analysis the expression of E-cadherin and β-catenin in 52 LSCC tissue samples. The authors showed that E-cadherin and β-catenin decrease lead to a greater local aggression and cervical metastases occurrence [ 53 ]. In a recent retrospective study, EMT-associated markers’ expression (E-cadherin, N-cadherin, β-catenin, and ZEB2) was analyzed in 76 stage I–IVa LSCC patients treated with surgery, with and without LNM, using IHC analysis.…”

The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas

“…Interestingly, low protein expression of E-cadherin in oral SCCs correlates with recurrence, poor cellular differentiation, metastatization and shorter overall survival [152,153]. Moreover, E-cadherin expression is positively correlated with the stages of oral SCC progression, as its expression increases during the transition from dysplasia to oral cancer [154,155].…”