2020
DOI: 10.5114/ada.2019.90060
|View full text |Cite
|
Sign up to set email alerts
|

The role of endocan and selected pro-inflammatory cytokines in systemic lupus erythematosus

Abstract: Introduction Systemic lupus erythematosus (SLE) is a multisystem inflammatory autoimmune disease with a wide spectrum of clinical manifestations. Cytokines such as interleukin-1 (IL-1) and tumour necrosis factor α (TNF-α) are involved in its pathogenesis. Endocan is a novel marker of endothelial dysfunction and is likely to be engaged in proinflammatory processes in SLE. Aim To determine whether endocan serum concentration in SLE patients vary from healthy controls. … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
3
0
1

Year Published

2022
2022
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 8 publications
(4 citation statements)
references
References 27 publications
0
3
0
1
Order By: Relevance
“…SLE studies confirmed VEGF association with disease activity [112][113][114]. Other studies found statistically lower VEGF levels in healthy controls compared with SLE [115], as well as AS patients [116][117][118]. A meta-analysis has demonstrated that VEGF levels may be a marker of inflammatory activity in RA and may play an important role in the inflammatory process, and higher VEGF levels were strongly correlated with the presence of RA [40].…”
Section: Discussionmentioning
confidence: 87%
“…SLE studies confirmed VEGF association with disease activity [112][113][114]. Other studies found statistically lower VEGF levels in healthy controls compared with SLE [115], as well as AS patients [116][117][118]. A meta-analysis has demonstrated that VEGF levels may be a marker of inflammatory activity in RA and may play an important role in the inflammatory process, and higher VEGF levels were strongly correlated with the presence of RA [40].…”
Section: Discussionmentioning
confidence: 87%
“…SLE patients not only have an increase in the prevalence of CAD, but also have the characteristics of severe coronary artery disease and an earlier age of onset. The serum endocan concentration of SLE patients was significantly higher than that of healthy people (55). Serum endocan level are positively correlated with cIMT, body mass index (BMI) and erythrocyte sedimentation rate in patients with SLE (56).…”
Section: Endocan and Atherosclerosismentioning
confidence: 94%
“…Studies found that it was significantly associated with cIMT. It may be a potential biomarker of early atherosclerosis [34,149,150].…”
Section: Other Biomarkersmentioning
confidence: 99%