The role of endomyocardial biopsy in the management of cardiovascular disease: A Scientific Statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology

Cooper, Leslie T.; Baughman, Kenneth L.; Feldman, Arthur M.; Frustaci, Andrea; Jessup, Mariell; Kühl, Uwe; Levine, Glenn N.; Narula, Jagat; Starling, Randall C.; Towbin, Jeffrey A.; Virmani, Renu

doi:10.1093/eurheartj/ehm456

Cited by 657 publications

(729 citation statements)

References 134 publications

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“…To overcome these diagnostic difficulties, endomyocardial biopsy (EMB) with immunohistochemistry is a further diagnostic option, which is widely accepted in the diagnostic cascade of myocardial inflammation. The overall complication rate of EMB is described as 6 % with severe complications appearing in 0.1 % to 0.5 % [25]. Considering the addressed risks in conjunction with its invasive character, EMB seems not to be justifiable in patients with less severe disease stages.…”

Section: Myocardial Inflammationmentioning

confidence: 99%

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Roller¹,

Harth²,

Schneider³

et al. 2015

Fortschr Röntgenstr

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!Cardiac magnetic resonance imaging (CMRI) is a versatile diagnostic tool. One of its main advantages is the possibility of tissue characterization. T1-weighted images for scar and T2-weighted images for edema visualization are key methods for tissue characterization. Otherwise these sequences are strongly limited for the detection of diffuse myocardial pathologies. Recently, rapid technical innovations have generated new techniques. T1, T2 mapping and evaluation of the extracellular volume fraction (ECV) allow quantification of diffuse myocardial pathologies and showed great potential in the visualization of fibrosis, edema, amyloid, iron overload and lipid. In the future these techniques might enable the detection of early cardiac involvement, even act as a prognosticator. Moreover, therapy monitoring and follow-up might be possible due to versatile parameter quantification with these new techniques. Key points:▶ CMR allows for tissue characterization via T1-and T2-weighted sequences.▶ In cases of diffuse, global myocardial pathologies, correct image interpretation with traditional CMR sequences might be difficult.▶ T1, T2 mapping and ECV can quantify diffuse, global myocardial pathologies.

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Section: Myocardial Inflammationmentioning

confidence: 99%

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Roller¹,

Harth²,

Schneider³

et al. 2015

Fortschr Röntgenstr

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“…In contrast, the most recent study showed that the major complication rate for left ventricular endomyocardial biopsies is 0.64% and that for right ventricular endomyocardial biopsies is 0.82%, thus indicating a lower risk compared with previous reports (14). The recently published guidelines of the American Heart Association, the American College of Cardiology and the European Society of Cardiology state that new-onset heart failure of two weeks duration associated with a normal-sized or dilated left ventricle and hemodynamic compromise is a class I indication for a left ventricular endomyocardial biopsy (15). In the present case, the patient's vital signs were stable during the early phase of the clinical course, and after the hemodynamic compromise occurred, performing an endomyocardial biopsy was of considerable risk due to severe thrombocytopenia.…”

Section: Discussionmentioning

confidence: 75%

Giant-Cell Myocarditis Complicated by Heparin-induced Thrombocytopenia

et al. 2012

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Giant-cell myocarditis is a fatal autoimmune disorder that is often associated with other autoimmune diseases. We herein describe a case of giant-cell myocarditis complicated by heparin-induced thrombocytopenia (HIT). A 71-year-old woman was admitted to our hospital due to palpitations and ptosis. Echocardiography revealed hypokinesis in the left basal ventricular walls. Heart failure gradually developed, and the condition was complicated by HIT. The patient died of cardiogenic and septic shock caused by agranulocytosis. An autopsy showed giant-cell myocarditis. When severe left ventricular dysfunction due to an unknown cause is complicated by HIT, potential diagnoses of giant-cell and other types of autoimmune myocarditis should thus be investigated.

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“…This assay requires a small sample such that precious cardiac tissues from biopsies or donors can be assayed. Biopsy is routinely performed for diagnosis of the presence and/or etiology of cardiomyopathy (61)(62)(63). It has a Ͻ1% complication rate (62).…”

Section: Discussionmentioning

confidence: 99%

Synthetic Phosphopeptides Enable Quantitation of the Content and Function of the Four Phosphorylation States of Phospholamban in Cardiac Muscle

Ablorh

Dong

James

et al. 2014

Journal of Biological Chemistry

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Background: Phosphorylation of phospholamban regulates cardiac calcium transport, but the content and function of the four phosphorylation states of phospholamban are unknown. Results: Synthetic phosphopeptides solved both problems. Conclusion:The phosphorylation states were quantified in normal and hypertrophic pig hearts, and each has a distinct effect on calcium transport. Significance: This information is needed for improved diagnosis and treatment of heart failure.

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Cited by 657 publications

References 134 publications

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Giant-Cell Myocarditis Complicated by Heparin-induced Thrombocytopenia

Synthetic Phosphopeptides Enable Quantitation of the Content and Function of the Four Phosphorylation States of Phospholamban in Cardiac Muscle

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