The Role of Endoscopic Findings for the Diagnosis of <i>Helicobacter pylori</i> Infection: Evaluation in a Country with High Prevalence of Atrophic Gastritis

Mihara, Mitsuhiro; Haruma, Ken; Kamada, Takenobu; Komoto, K; Yoshihara, Masaharu; Sumii, Koji; Kajiyama, Goro

doi:10.1046/j.1523-5378.1999.09016.x

Cited by 93 publications

(97 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well known that H. pylori infection causes endoscopic gastritis with persistent infection, presenting as erythema, erosion, haemorrhagic and large gastric folds. 16 Several studies [17][18][19] have shown that eradication of H. pylori improves H. pylori-related endoscopic gastritis as well as histological gastritis. Therefore, improvement in endoscopic gastritis with eradication of H. pylori might have contributed to the detection of potential gastric cancer within 48 months after eradication in our DU, duodenal ulcer; GU, gastric ulcer; AG, atrophic gastritis; GCa, gastric cancer; ER, endoscopic resection.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, all patients with gastric cancer discovered after eradication had severe baseline mucosal atrophy in the corpus, and the gastric cancers were mainly early non-cardiac cancers of the intestinal type with ulcers. Atrophic gastritis and gastric cancer are common in Japan, 16,20,21 and this highlights need for careful endoscopic follow-up. Recent studies showed that eradication of H. pylori contributes to the chemoprevention of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9‐year prospective follow‐up study in Japan

Kamada

Hata

Sugiu

et al. 2005

Aliment Pharmacol Ther

136

149

View full text Add to dashboard Cite

SUMMARYBackground: Eradication of Helicobacter pylori is expected to prevent the development of gastric cancer. However, gastric cancer is sometimes discovered after successful eradication of H. pylori. Aim: To conduct a prospective study to determine the clinical features of patients who underwent successful eradication and were later diagnosed with gastric cancer. Methods: A total of 1787 patients (1299 males and 488 females; mean age, 58.2 years; range: 15-84) who underwent successful eradication therapy between April 1994 and March 2001 were our study subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9‐year prospective follow‐up study in Japan

Kamada

Hata

Sugiu

et al. 2005

Aliment Pharmacol Ther

136

149

View full text Add to dashboard Cite

show abstract

“…The inflammatory process is initially superficial but, in sequence, affects the entire mucosa, first in the antrum and progressing proximally to the body. Over the years, the gastric glands are destroyed showing epithelial atrophy and intestinal metaplasia areas that favor the appearance of gastric carcinoma [2] . The diagnosis of the infection requires at least two tests in accordance with the European guidelines [3] .…”

Section: Introductionmentioning

confidence: 99%

Conventional Videoendoscopy and Endoscopic Findings Related to Helicobacter Pylori

Gomes¹,

Skare²,

Internationals³

2017

JGDLF

View full text Add to dashboard Cite

Background: Studies with the latest technologies such as endoscopy with magnification and chromo endoscopy showed that various endoscopic aspects are clearly related to infection by Helicobacter pylori (HP). The description of different patterns of erythema in gastric body under magnification of images revived interest in identifying these patterns by standard endoscopy. Aim: Validate endoscopic aspects related to HP found in conventional video gastroscopy, allowing the predictability of the diagnosis as well as proper targeting biopsies. Methods: Prospective study of 339 consecutive patients with the standard video endoscope image analysis were obtained, recorded and stored in a program database. These images were studied with respect to the presence or absence of HP, diagnosed by rapid urease test and/or by histological analysis. Were studied: a) normal mucosa appearance b) mucosal nodularity c) diffuse nonspecific erythema or redness of antrum and body d) mosaic pattern with focal area of hyperemia e) erythema in streaks or bands (red streaks) f) elevated (raised) erosions g) flat erosions h) fundic gland polyps. The main exclusion criteria were the use of drugs, HP pre-treatment and other entities that could affect results. Results: Applying the exclusion criteria, were included 170 of the 339 patients, of which 52 (30.58%) were positive for HP and 118 negative. On the positive findings, the most associated with infection were: antral nodularity (26.92%); raised erosion (15.38%) and mosaic pattern in the body (21.15%). On the negative group the normal appearance of the mucosa was 66.94%; red streaks in 9.32%; flat erosions 11.86%; and fundic gland polyps 11.86%. Conclusion: Endoscopic findings are useful in predicting the outcome, localization and targeting of biopsies in gastritis related to HP infection. The most representative form of HP related gastritis was the nodularity of the antral mucosa. The raised erosion and mosaic pattern in the body are suggestive but not specific to the infection. Normal-appearing forms, red streaks and fundic gland polyposis are related to the negativity of HP infection. The other forms were not conclusive of the presence of HP.

show abstract

“…The gastroscopic findings of H. pylori infected gastric mucosa were erythema, erosions, antral nodularity, thickened gastric folds, and visible submucosal vessels. However, these findings are not a reliable method of diagnosis because of their low sensitivity and specificity (Laine et al, 1995;Bah et al, 1995;Mihara et al, 1999;Redeen S et al, 2003). In 2010, Taiwanese endoscopist a study using close-up observation between the endoscope tip and the gastric mucosa and found the "mosaic pattern" in the corpus mucosa.…”

Section: Introductionmentioning

confidence: 99%

Improved Detection of Helicobacter pylori Infection and Premalignant Gastric Mucosa Using Conventional White Light Source Gastroscopy

Matrakool¹,

Tongtawee²,

Bartpho³

et al. 2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The gold standard diagnosis of H. pylori related gastritis is evidence of bacteria on histopathological examination of gastric mucosa. Our aim was to study the correlation between gastric mucosal morphology and histopathological severity of H. pylori related gastritis. Materials and Methods: Division was made on morphological features into:Type 1, showing regular arrangement of red dots; Type 2, showing cleft-like appearance; Type 3, with a mosaic appearance; and Type 4, having a mosaic appearance with focal or diffuse hyperemia. Results: Types 1 and 2 gastric mucosal morphologies were statistically significant in predicting an H. pylori negative status (137/145, p<0.01), while Types 3 and 4 were significant a positive status (139/155, p<0.01). The sensitivity, specificity, positive and negative predictive values of Type 3 and 4 morphologies for predicting H. pylori positive were 94.6%, 89.5%, 89.7% and 94.5%, respectively, with a good correlation with inflammation grading (p<0.01). Conclusions: Our study suggests that gastric mucosal morphology can be reliably identified using conventional white light source gastroscopy with good correlation between findings and inflammation grading.

show abstract

The Role of Endoscopic Findings for the Diagnosis of Helicobacter pylori Infection: Evaluation in a Country with High Prevalence of Atrophic Gastritis

Abstract: The accurate endoscopic assessment of gastritis according to the Sydney system along with gastric fold findings and the endoscopically identified extent of gastric atrophy are valuable indicators for determining H. pylori infection and histologic gastritis in the Japanese population.

Cited by 93 publications

References 22 publications

Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9‐year prospective follow‐up study in Japan

Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9‐year prospective follow‐up study in Japan

Conventional Videoendoscopy and Endoscopic Findings Related to Helicobacter Pylori

Improved Detection of Helicobacter pylori Infection and Premalignant Gastric Mucosa Using Conventional White Light Source Gastroscopy

Contact Info

Product

Resources

About