The role of endothelin-1 in hyperoxia-induced lung injury in mice

Abstract

These findings substantiate the involvement of the ET-1 receptors in the physiopathogenesis of hyperoxia-induced lung damage. Dual ET-1 receptor antagonism may well be of value in the prevention of hyperoxia-induced parenchymal damage.

Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure

“…The 72-hour exposure to hyperoxia in the present study resulted in increases in the basal values of both viscoelastic tissue parameters (Figure 1 ; G · BW and H · BW), which accords with the results of previous studies, where a decreased compliance was found after oxygen toxicity [ 19 , 36 – 38 ]. Since the hyperoxia-induced increases in G · BW and H · BW were proportional, the enhancement of ventilation heterogeneities was not likely to have played a role in these findings [ 39 ].…”

“…In accordance with earlier results when immature rats were exposed to oxygen for a short time [ 16 ], the basal Raw was not affected by hyperoxia exposure (Figure 1 ) and is also in line with the notion that Raw is determined primarily by the geometry of the central conducting airways, which remained unaffected [ 19 , 34 , 35 ]. An airway obstruction was detected in earlier studies when exposure to oxygen was applied for a prolonged period (e.g.…”

“…The chronic presence of all these pathophysiological changes may lead to airway and vascular remodeling in the lungs, with subsequent pulmonary hypertension [ 2 , 11 – 14 ], fibrosis and the development of irreversible changes in the lung structure [ 15 – 18 ]. All these pathways contribute to the hyperoxia-induced development of bronchial hyperreactivity (BHR) [ 13 , 14 , 16 , 17 , 19 ], which plays a major role in the frequent development of respiratory adverse events due to the enhanced lung responsiveness to exogenous constrictor stimuli.…”

Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy

“…We found an early significant decrease in Edn1 lung expression following kidney IRI, and therefore found it to be an ideal candidate gene to validate our ability to accurately measure genes whose expression is deactivated following treatment. In addition, Edn-1 is a potent vasoconstrictor and its expression is associated with pulmonary endothelial injury and microvascular leak (15,21). The deactivation of gene expression at 6 h may represent a response to an increase in early protein abundance or activity, and given that it is also the gene with most links to "acute lung injury" term in the PubMed database, makes Edn1 an attractive candidate gene to be investigated as a potential mediator of AKI-induced ALI in future studies.…”

Differential roles of endothelin‐1 ETA and ETB receptors and vasoactive intestinal polypeptide in regulation of the airways and the pulmonary vasculature in isolated rat lung

“…endothelin‐1, ET‐1) and vasorelaxing and antiproliferative mediators (e.g. vasoactive intestinal polypeptide, VIP) may not only lead to PHT, but also alter the lung function via the bronchoactive potential of these peptides (Keith, 2000; Grimm et al 2003; Habre et al 2006; Hoeper & Rubin, 2006; McLaughlin & McGoon, 2006).…”