The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma

Tota, Maciej; Łacwik, Julia; Laska, Julia; Sędek, Łukasz; Gomułka, Krzysztof

doi:10.3390/cells12091326

Cited by 11 publications

(3 citation statements)

References 233 publications

(236 reference statements)

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“…Other two approved therapies block either IL-4R on T cells or IL-5R on eosinophils. Other drugs are currently tested in vitro, in mice, phase 1 and 2 clinical studies [39].…”

Section: The Current Research In Asthmamentioning

confidence: 99%

The Immune Response in the Pathophysiology of Pulmonary Diseases

Navratilova,

Kominkova,

Petrek

2024

Physiology

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Chronic obstructive pulmonary disease (COPD) is the world’s third leading cause of death. The number of patients with asthma is increasing in developed countries. We review here the main features of pathophysiology in these obstructive diseases. Tobacco smoke and other air pollution stimulate chronic inflammation in COPD. Asthma is a type 1 hypersensitivity that is a response to various allergens. In both pathologies, chronic inflammatory response leads to airway remodeling, significantly impacting lung function and a patient’s daily activity. Besides imaging techniques, a critical diagnostic tool is a pulmonary function test with characteristic obstructive patterns and respiratory symptoms. Sarcoidosis is discussed as an example of a restrictive disease. Finally, we shortly highlight the direction of current research.

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“…Other two approved therapies block either IL-4R on T cells or IL-5R on eosinophils. Other drugs are currently tested in vitro, in mice, phase 1 and 2 clinical studies [39].…”

Section: The Current Research In Asthmamentioning

confidence: 99%

The Immune Response in the Pathophysiology of Pulmonary Diseases

Navratilova,

Kominkova,

Petrek

2024

Physiology

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“…And eosinophils produce a number of mediators which cause tissue damages after activation. These substances include eosinophil cationic protein, major basic protein, eosinophil peroxidase, and eosinophil-derived neurotoxin [67,68]. These cells also release various cytokines and growth factors like transforming growth factor (TGF)-β. TGFβ plays an important role in the airway tissue remodeling [69].…”

Section: Allergic Asthmamentioning

confidence: 99%

Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid and the OXE Receptor in Allergic Diseases: Collegium Internationale Allergologicum Update 2024

Lin,

Dai,

Wei

et al. 2024

Int Arch Allergy Immunol

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Background: 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-Oxo-ETE) is a metabolite of arachidonic acid shown to promote biological activities in different cell types. Summary: 5-Oxo-ETE is synthesized from the 5-lipoxygenase product 5S-HETE (5S-hydroxy-6,8,11,14-eicosatetraenoic acid) in the presence of the nicotinamide adenine dinucleotide phosphate (NADP)+-dependent enzyme 5-hydroxyeicosanoid dehydrogenase (5-HEDH). Under some conditions that promote oxidation of NADPH to NADP+, such as the respiratory burst in phagocytic cells, eosinophils, and neutrophils, oxidative stress in monocytes and dendritic cells, and cell death, 5-Oxo-ETE synthesis can be dramatically increased. In addition, 5-Oxo-ETE can also be formed in the absence of 5-lipoxygenase in cells through transcellular biosynthesis by inflammatory cell-derived 5S-HETE. This compound performs its biological activities by the highly selective Gi/o-coupled OXE receptor, which is highly expressed on eosinophils, neutrophils, basophils, and monocytes. As such, 5-Oxo-ETE is a potent chemoattractant for these inflammatory cells, especially for eosinophils. Key Messages: Although the pathophysiological role of 5-Oxo-ETE is not clearly understood, 5-Oxo-ETE may be a significant mediator in allergic diseases, such as allergic asthma, allergic rhinitis, and atopic dermatitis. And targeting the OXE receptor may be a novel therapy for this kind of inflammatory condition. Nowadays, selective OXE receptor antagonists are currently under investigation and could become potential therapeutic agents in allergy.

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“…EA is characterized by eosinophilia in tissue and sputum and a thickening of the basement membrane. [4][5][6] Some patients with EA respond well to corticosteroids, while others experience improvements in exacerbation frequency, but not symptom intensity. 5 Other patients with EA are "steroid-refractory", or resistant to corticosteroids altogether, and often have better outcomes when treated with leukotriene receptor agonists.…”

Section: Introductionmentioning

confidence: 99%

Global Burden of Asthma, and Its Impact on Specific Subgroups: Nasal Polyps, Allergic Rhinitis, Severe Asthma, Eosinophilic Asthma

Rabe,

Loke,

Gurjar

et al. 2023

JAA

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Background The complex nature of asthma has resulted in a poor understanding of its epidemiology, particularly in low-and middle-income countries (LMIC). Clinical subgroups, such as patients with severe asthma, eosinophilic asthma, allergic rhinitis, or nasal polyps, experience additional barriers to care. Methods Prevalence estimates for asthma and key clinical subgroups were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 and from a targeted literature review conducted through PubMed in October of 2021. National estimates were calculated and the roles of potential explanatory factors were explored through qualitative analysis. Results In total, 162 publications from 69 countries were included. Across continents, asthma prevalence values ranged from 3.44% (Asia), 3.67% (Africa), 4.90% (South America), 5.69% (Europe), 8.29% (North America), to 8.33% (Oceania). Globally, of those with asthma, 26.70% had severe asthma, 30.99% had eosinophilic asthma, 48.95% had allergic rhinitis, and 7.0% to 25.40% had nasal polyps. Countries with higher air quality, income status, and healthcare access and quality reported a higher asthma prevalence. Conclusion Asthma prevalence values were low in LMICs, potentially indicating health system deficiencies resulting in low diagnosis and reporting. The prevalence of eosinophilic asthma and severe asthma phenotypes was high in many countries, although the prevalence estimates of all asthma subgroups were quite variable.

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The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma

Cited by 11 publications

References 233 publications

The Immune Response in the Pathophysiology of Pulmonary Diseases

The Immune Response in the Pathophysiology of Pulmonary Diseases

Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid and the OXE Receptor in Allergic Diseases: Collegium Internationale Allergologicum Update 2024

Global Burden of Asthma, and Its Impact on Specific Subgroups: Nasal Polyps, Allergic Rhinitis, Severe Asthma, Eosinophilic Asthma

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