The role of eosinophils and eosinophil cationic protein in oral cancer: A review

In this paper we use eQTL mapping to identify associations between gene dysregulation and single nucleotide polymorphism (SNP) genotypes in glioblastoma multiforme (GBM). A set of 532,954 SNPs was evaluated as predictors of the expression levels of 22,279 expression probes. We identified SNPs associated with fold change in expression level rather than raw expression levels in the tumor. Following adjustment for false discovery rate, the complete set of probes yielded 9257 significant associations (p<0.05). We found 18 eQTLs that were missense mutations. Many of the eQTLs in the non-coding regions of a gene, or linked to nearby genes, had large numbers of significant associations (e.g. 321 for RNASE3, 101 for BNC2). Functional enrichment analysis revealed that the expression probes in significant associations were involved in signal transduction, transcription regulation, membrane function, and cell cycle regulation. These results suggest several loci that may serve as hubs in gene regulatory pathways associated with GBM.

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“…Dysregulation of this gene has previously been documented in association with glioblastoma [12] and other cancers (e.g. [48]). …”

Section: Discussionmentioning

confidence: 97%

An eQTL analysis of the human glioblastoma multiforme genome

et al. 2014

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“…Eosinophils produce several angiogenic factors and may promote lesion angiogenesis [1,13]. Furthermore, they can break down basement membrane and extracellular matrix via the release of several matrix metalloproteinases and their inhibitors [1].…”

Section: Discussionmentioning

confidence: 99%

Tissue eosinophilia: a histopathological marker associated with stromal invasion but not histopathological grade in cutaneous squamous neoplasia

2015

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Tumor-associated tissue eosinophilia was first described in 1896 in cervical carcinoma and is defined as eosinophilic infiltration in a tumor that is not associated with necrosis or ulceration. Its functional role remains unclear [1]. Eosinophilic infiltration has been reported in carcinomas located in the oral cavity, larynx, pharynx, gastrointestinal tract, lungs, cervix, and external genitalia; however, the literature includes limited data on eosinophilic infiltration in cutaneous squamous cell carcinoma (SCC) [1,2].Objectives. The literature does not include any comparative study on the eosinophil count in premalignant and malignant cutaneous squamous neoplasias. Our aim was to compare the tissue eosinophilic count in actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC). Methods. The study included 20 AK and 20 invasive SCC patients. Age, gender, and lesion location were retrospectively evaluated as clinical parameters. Histopathological parameters included density of inflammation score, lesion grade, and the lesion-associated eosinophil count per 10 high-power (40×) microscopic fields, all of which were compared between groups. Results. In all, 65% of the AK group had lesions with moderate inflammation, whereas 85% of the SCC group had lesions with dense inflammation (p=0.001). The mean eosinophil count in the SCC group was significantly higher than that in the AK group, independent of the density of inflammation (p=0.000). In addition, lesion grade was not associated with the eosinophil count in either group (AK group: p=0.601; SCC group: p=0.416). Conclusions. Cutaneous SCC lesions had higher eosinophil counts than AK lesions, indicating the role of the eosinophil count as a histopathological marker of stromal invasion.

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“…In vitro studies could prove the direct cytotoxicity of eosinophil cationic protein (ECP) [ 83 , 84 , 87 ]. ECP causes lysis of tumor cells by creating pores in the cell membrane [ 88 ]. Further granule proteins like major basic protein or eosinophil peroxidase have indirect antitumor properties in terms of triggering the release of histamine from mast cells.…”

Section: Tumor-protecting Effects Of Allergiesmentioning

confidence: 99%