The role of ethanol availability on stress-induced increases in ethanol consumption

Bowers, Wayne J.; Sabongui, Amir G.; Amit, Zalman

doi:10.1016/s0741-8329(96)00046-8

Cited by 33 publications

(14 citation statements)

References 45 publications

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“…Although ours is the first to examine the effects of footshock and social defeat on ADE, two previous studies tested the effects of restraint stress. Bowers et al (1997) showed that repeated daily restraint during a deprivation period increased subsequent alcohol consumption, while Breese et al (2003), using two deprivation cycles, found a similar effect of restraint in alcohol preferring P-rats. Our study extends these findings in showing that footshock and social defeat can also facilitate the development of ADE.…”

Section: Discussionmentioning

confidence: 93%

Influence of stressors on the rewarding effects of alcohol in Wistar rats: studies with alcohol deprivation and place conditioning

2004

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Section: Discussionmentioning

confidence: 93%

Influence of stressors on the rewarding effects of alcohol in Wistar rats: studies with alcohol deprivation and place conditioning

2004

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“…progressive ratio schedule]- [489]). Animal models of ethanol ingestion have likewise reported a stress-induced facilitation of ethanol consumption [54], although the interaction of stress and ethanol intake is complex, with increases in ethanol consumption often becoming evident during the recovery period following chronic stressor exposure (see Ref. [429] for review).…”

Section: Stress and Drug Abuse In Adolescentsmentioning

confidence: 99%

The adolescent brain and age-related behavioral manifestations

Spear

2000

Neuroscience & Biobehavioral Reviews

4,742

110

4,301

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To successfully negotiate the developmental transition between youth and adulthood, adolescents must maneuver this often stressful period while acquiring skills necessary for independence. Certain behavioral features, including age-related increases in social behavior and risk-taking/novelty-seeking, are common among adolescents of diverse mammalian species and may aid in this process. Reduced positive incentive values from stimuli may lead adolescents to pursue new appetitive reinforcers through drug use and other risk-taking behaviors, with their relative insensitivity to drugs supporting comparatively greater per occasion use. Pubertal increases in gonadal hormones are a hallmark of adolescence, although there is little evidence for a simple association of these hormones with behavioral change during adolescence. Prominent developmental transformations are seen in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems. Developmental changes in these stressor-sensitive regions, which are critical for attributing incentive salience to drugs and other stimuli, likely contribute to the unique characteristics of adolescence. ᭧

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“…In some cases, acute exposure to stressors such as footshock, cold water swim, or brief restraint increase alcohol intake (Fullgrabe et al 2007;Lynch et al 1999;Siegmund et al 2005;), whereas other studies fi nd no effect or even a negative effect of stress on alcohol intake. For example, studies have reported that single or repeated restraint stress or footshock had no effect on alcohol intake (Bowers et al 1997;Funk et al 2004;Tambour et al 2008), or that a reduction in alcohol intake was produced by social defeat stress (Anacker and Ryabinin 2010;Funk et al 2004;van Erp and Miczek 2001), novelty-related stress (Sabino et al 2006), restraint stress (Chester et al 2004;Rockman and Glavin 1986), or cold water swim (BoyceRustay et al 2008). Resolving these mixed results is challenging, as there are many potential differences, such as type of stressor, species or strain of rat or mouse, and paradigm of alcohol exposure, as evidenced in the following examples.…”

Section: Mixed Results Of Stressors In Rodent Models Of Self-administmentioning

confidence: 99%

“…Alcohol intake in these models is increased by stressors such as administration of the anxiogenic yohimbine, footshock, social defeat, or restraint (Bowers et al 1997;Funk et al 2004;Le et al 2000;Liu and Weiss 2002;Simms et al 2010; but see Dayas et al 2004) even when no alcohol reward is delivered (perhaps suggesting increased motivation), similar to stress-induced reinstatement for other drugs of abuse (e.g., cocaine, heroin; Epstein et al 2006;McFarland et al 2004;Shalev et al 2010;Vanderschuren and Everitt 2004). A relatively conserved neural circuit that mediates footshock-induced reinstatement of alcohol seeking in rodents (Epstein et al 2006;McFarland et al 2004) is also activated in human alcoholics and addicts by drug-or alcoholassociated cues and stress (Koob and Volkow 2010;Sinha 2009), and the level of brain activation can predict future alcohol intake or relapse in humans (Sinha 2009).…”

Section: Stressors and Alcohol Intake In Rodent Models Of Relapsementioning

confidence: 99%

Translational Models of Interactions Between Stress and Alcohol Consumption: Strengths and Limitations

Hopf¹,

Sparta²,

Bonci³

2011

ILAR Journal

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Much has been written about the interaction of stressors (physical, social, and psychological) and alcohol addiction based on studies in humans and preclinical models. We begin by considering the significance and complexity of alcoholism and the options for effectively modeling it in animals, particularly rodents. We then focus on the following aspects of stress-alcohol interactions: (1) compulsive alcohol consumption, characterized by continued intake despite the presence of stressful or aversive consequences; (2) the possible relationship between acute stress and increased alcohol intake; (3) an apparent cross sensitization of stress and alcohol exposure, which increases both future reactivity to stress and the risk of developing alcohol addiction; and (4) efforts to target stress in therapeutic interventions for alcoholism. We also describe possible neuroadaptations and genetic factors that may interact with stress to increase susceptibility to alcoholism. Throughout, we describe the challenges and inconsistencies inherent in both human and animal studies of alcoholism, its etiology, and its impacts. We believe the relationship between preclinical and human studies is of paramount importance to understand addiction-related behavior in humans and to direct, improve, and expand animal models. It is our hope that a full understanding of the mechanistic bases of pathological alcohol intake will have translational benefits for the development of behavioral and pharmacological therapies.

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The role of ethanol availability on stress-induced increases in ethanol consumption

Cited by 33 publications

References 45 publications

Influence of stressors on the rewarding effects of alcohol in Wistar rats: studies with alcohol deprivation and place conditioning

Influence of stressors on the rewarding effects of alcohol in Wistar rats: studies with alcohol deprivation and place conditioning

The adolescent brain and age-related behavioral manifestations

Translational Models of Interactions Between Stress and Alcohol Consumption: Strengths and Limitations

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