The role of ethanol in the pathogenesis of non‑bacterial prostatitis

Liu, Feng; Liu, Lintao; Zhong, Weihong; Chen, Lin; Yu, Jiabin; Xu, Xiaolin

doi:10.3892/mmr.2019.9991

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Regular alcohol consumption was obviously associated with an increased percentage of patients with symptoms unchanged or worse in both the treated and untreated groups, which was consistent with previous studies (Collins et al, 2002; Herati et al, 2013; Krieger et al, 2008). One possible explanation is that the ethanol level in circulation could result in prostate congestion (Liu et al, 2019), aggravating local pain and discomfort. Although smoking is usually considered to be a harmful factor for CPPS (Chen et al, 2016), the adverse effect of smoking on the prognosis of CPPS was not obviously observed in this study.…”

Section: Discussionmentioning

confidence: 99%

The Lifetime Risk and Prognosis of Chronic Prostatitis/Chronic Pelvic Pain Syndrome in the Middle-Aged Chinese Males

Zhang

Cai

et al. 2019

Am J Mens Health

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Knowledge is limited about the lifetime risk of chronic pelvic pain syndrome (CPPS) occurrence in Chinese middle-aged males and the prognosis of CPPS patients with and without treatment. Noninstitutionalized Chinese males aged 40 to 81 years were enrolled in this study from a total of 76 local communities across 30 provinces of China. Information about the occurrence of CPPS, symptom relief, and previous treatment was collected. Based on completed answers to specific questions about self-reported and physician-diagnosed CPPS, the lifetime risk of CPPS occurrence was 25.3% (1,091 out of 4,315) in Chinese males aged 40 to 81 years. Over 77% of patients with CPPS had received treatment. The symptom relief rate was not significantly different between the treatment (57.3%, 142/248) and nontreatment (50.1%, 422/843) groups. Regardless of whether patients had received medical treatment, engagement in sedentary work and regular alcohol consumption had a significant negative influence, while marriage had a positive influence, on the prognosis of CPPS. A good prognosis could be achieved without treatment for some cases of CPPS, while others required a timely symptom-orientated treatment using adequate medications combined with lifestyle adjustment and follow-up.

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Section: Discussionmentioning

confidence: 99%

The Lifetime Risk and Prognosis of Chronic Prostatitis/Chronic Pelvic Pain Syndrome in the Middle-Aged Chinese Males

Zhang

Cai

et al. 2019

Am J Mens Health

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“…Chronic and acute alcohol administration in rats results in the following significant alterations in prostate epithelial cells: disorganization of Golgi [68,69], accumulation of lipid droplets, rupture of the microvilli [70], dilatation of the endoplasmic reticulum (ER), significant condensation of chromatin around the nuclear membrane, and increased presence of apoptotic cells [71]. EtOH may accelerate the inflammatory response in rats with nonbacterial prostatitis [72]. Interestingly, the ventral lobe of the prostate from rats exposed to 6.7% EtOH (v/v) during the prenatal period (day 11-21) demonstrated significant inflammation, epithelial atypia, and an increased number of proliferative cells [73].…”

Section: Alcohol's Influence On the Hormonal Status And Prostate Epit...mentioning

confidence: 99%

Alcohol and Prostate Cancer: Time to Draw Conclusions

Macke

Petrosyan

2022

Biomolecules

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It has been a long-standing debate in the research and medical societies whether alcohol consumption is linked to the risk of prostate cancer (PCa). Many comprehensive studies from different geographical areas and nationalities have shown that moderate and heavy drinking is positively correlated with the development of PCa. Nevertheless, some observations could not confirm that such a correlation exists; some even suggest that wine consumption could prevent or slow prostate tumor growth. Here, we have rigorously analyzed the evidence both for and against the role of alcohol in PCa development. We found that many of the epidemiological studies did not consider other, potentially critical, factors, including diet (especially, low intake of fish, vegetables and linoleic acid, and excessive use of red meat), smoking, family history of PCa, low physical activity, history of high sexual activities especially with early age of first intercourse, and sexually transmitted infections. In addition, discrepancies between observations come from selectivity criteria for control groups, questionnaires about the type and dosage of alcohol, and misreported alcohol consumption. The lifetime history of alcohol consumption is critical given that a prostate tumor is typically slow-growing; however, many epidemiological observations that show no association monitored only current or relatively recent drinking status. Nevertheless, the overall conclusion is that high alcohol intake, especially binge drinking, is associated with increased risk for PCa, and this effect is not limited to any type of beverage. Alcohol consumption is also directly linked to PCa lethality as it may accelerate the growth of prostate tumors and significantly shorten the time for the progression to metastatic PCa. Thus, we recommend immediately quitting alcohol for patients diagnosed with PCa. We discuss the features of alcohol metabolism in the prostate tissue and the damaging effect of ethanol metabolites on intracellular organization and trafficking. In addition, we review the impact of alcohol consumption on prostate-specific antigen level and the risk for benign prostatic hyperplasia. Lastly, we highlight the known mechanisms of alcohol interference in prostate carcinogenesis and the possible side effects of alcohol during androgen deprivation therapy.

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“…Etiologia tego zespołu nie jest w pełni znana, z tego powodu postawienie ostatecznej diagnozy jest utrudnione. Powszechnie przyjmuje się, że za objawy chorobowe nie jest wyłącznie odpowiedzialny stan zapalny w prostacie, ale również bakterie, czynniki neuropsychologiczne, zaburzenia immunologiczne, stres oksydacyjny, nieprawidłowości mięśni dna miednicy, zaburzenia endokrynologiczne [6] oraz nadmierne spożywanie etanolu [7] . Przypuszcza się również, że sporty związane z energicznym zginaniem bioder lub długotrwałym uciskiem krocza mogą prowadzić do uwięźnięcia nerwu sromowego [8] co prowadzi do objawów występujących w CNP/CPPS.…”

Section: Wprowadzenieunclassified

Chronic Prostatitis / Chronic Pelvic Pain Syndrome – problematic common disease. Current knowledge on etiology, diagnosis and treatments

ŻOŁYNIAK¹,

ŻABA²,

WARZYSZAK³

et al. 2022

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Introduction: Nonbacterial prostatitis (CNP) also known as chronic pelvic pain syndrome (CPPS) is a condition with an incompletely understood etiology. Chronic prostatitis is diagnosed when symptoms of prostatitis persist for more than 3 months and it is difficult to treat. The causes are not fully understood. Among the many possible causes are stress, psycho-emotional disorders, hormonal disorders and autoimmune disorders. The main symptom is pain usually felt in the perineum, at the base of the penis, in the anal area, sometimes over the pubic symphysis. This pain can radiate to the penis and scrotum. Aim of the study: Summary of current knowledge on the treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Material and methods: Review of PubMed articles using the following keywords: “nonbacterial chronic prostatitis”, “abacterial chronic prostatitis” and “chronic pelvic pain syndrome”. Results: Complete cure in non-bacterial chronic prostatitis is rare. Due to the lack of knowledge of the cause of chronic prostatitis, there is no effective treatment for this disease. Although the pathogen is rarely found in the patients studied, many patients show improvement after antibiotic therapy. In addition, anti-inflammatory drugs, alpha blockers and neuromodulators are used. Physical therapy also has proven benefits in relieving symptoms. Conclusion: CNP is a frustrating disease for many doctors and patients. Although it is not yet completely understood, we have made significant progress in the evaluation and treatment of this disease over the past several decades. Physicians need to move away from outdated algorithms that often result in endless courses of antibiotics and embrace multimodal therapy, which provides better results than other treatment strategies.

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The role of ethanol in the pathogenesis of non‑bacterial prostatitis

Cited by 3 publications

References 23 publications

The Lifetime Risk and Prognosis of Chronic Prostatitis/Chronic Pelvic Pain Syndrome in the Middle-Aged Chinese Males

The Lifetime Risk and Prognosis of Chronic Prostatitis/Chronic Pelvic Pain Syndrome in the Middle-Aged Chinese Males

Alcohol and Prostate Cancer: Time to Draw Conclusions

Chronic Prostatitis / Chronic Pelvic Pain Syndrome – problematic common disease. Current knowledge on etiology, diagnosis and treatments

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