“…The chronic inflammatory systemic feature of JIA is mediated by cytokine products of an activated immune system, including tumor necrosis factor (TNF)-α, interleukin-1 (IL-1) and interleukin-6 (IL-6) [3,4]. Aftereffects of JIA can include pain, fatigue, reduced fitness, reduced activity, sleep disturbances, muscle atrophy, decreased bone mineral composition (BMC) and impaired quality of life [1,5], as well as growth retardation (with low IGF-1 levels in all disease onset subtypes) [6]. Furthermore, chronic inflammation can lead to numerous abnormalities including anorexia, cachexia, cachectic obesity, dyslipidemia and insulin resistance [7].…”