The role of Experiential Avoidance in transdiagnostic compulsive behavior: A structural model analysis

Ouden, Lauren Den; Tiego, Jeggan; Lee, Rico S.C.; Albertella, Lucy; Greenwood, Lisa-Marie; Fontenelle, Leonardo F.; Yücel, Murat; Segrave, Rebecca

doi:10.1016/j.addbeh.2020.106464

Cited by 16 publications

(11 citation statements)

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“…OCD patients, regardless of treatment engagement status, have lower levels of BDNF compared to healthy controls (Fontenelle et al, 2012; Maina et al, 2010; Wang et al, 2011). While cognitive inflexibility and psychological stress are drivers of OCS severity (Chamberlain et al, 2006; Den Ouden et al, 2020), increased BDNF is associated with greater cognitive flexibility and resilience to stress (Giese et al, 2013; Schmitt et al, 2016). Therefore, it seems reasonable to speculate that lifestyle behaviours such as physical activity (Dinoff et al, 2017), stress-management activities (Cahn et al, 2017), probiotic use (Haghighat et al, 2021; Kim et al, 2021) and adherence to a Mediterranean diet (with a particular supplementation of nuts) (Sánchez-Villegas et al, 2011) may ameliorate OCD symptoms through increased BDNF and resulting cognitive flexibility.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle risk factors for obsessive-compulsive symptoms and related phenomena: What should lifestyle interventions target?

Brierley

Albertella

Christensen

et al. 2022

Aust N Z J Psychiatry

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Objective: Understanding the impact of lifestyle on mental illness symptoms is important for informing psycho-education and developing interventions which target mental and physical comorbidities. Obsessive-compulsive and related disorders can have a significant impact on health-related quality of life and physical health. However, our understanding of the impact of lifestyle on obsessive-compulsive symptoms and broader compulsive and impulsive problematic repetitive behaviours is limited. Aims: We investigated whether lifestyle factors predicted change in obsessive-compulsive symptoms and problematic repetitive behaviours in a general population sample over a 3-month period. Methods: Eight hundred thirty-five participants completed an online questionnaire battery assessing lifestyle and mental health. Of these, 538 participants completed the same battery 3 months later. We conducted negative binomial regressions to analyse the association of lifestyle factors at baseline with future (1) obsessive-compulsive symptoms, (2) compulsive problematic repetitive behaviours and (3) impulsive problematic repetitive behaviours, adjusting for baseline obsessive-compulsive symptoms and problematic repetitive behaviours. Results: Lower vegetable ( p = 0.020) and oily fish ( p = 0.040) intake and lower moderate intensity physical activity ( p = 0.008) predicted higher obsessive-compulsive symptoms at follow-up. Higher intake of high-fat foods ( p < 0.001) predicted higher compulsive problematic repetitive behaviours at follow-up. No lifestyle factors significantly predicted impulsive problematic repetitive behaviours at follow-up. Conclusion: Our results speak to the potential importance of lifestyle quality screening, education and lifestyle interventions (e.g. an anti-inflammatory diet) for individuals experiencing compulsivity-related behaviours and/or symptoms. Further research into potential mechanisms of action will allow for more targeted approaches to lifestyle interventions for transdiagnostic compulsive behaviours.

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Section: Discussionmentioning

confidence: 99%

Lifestyle risk factors for obsessive-compulsive symptoms and related phenomena: What should lifestyle interventions target?

Brierley

Albertella

Christensen

et al. 2022

Aust N Z J Psychiatry

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“…For convenience, and in line with previous studies [ 65 ], compulsivity was quantified using total Y-BOCS scores across disorders, which incorporates obsessions and compulsions (both of which are highly correlated and intrinsically linked [ 66 , 103 ]). Nonetheless, future work could consider other conceptualizations of compulsivity.…”

Section: Discussionmentioning

confidence: 99%

“…While the inclusion criteria of ≥ 5 on the compulsive subscale of the Y-BOCS was used to ensure the data captured self-reported compulsive phenotypes associated with the repetitively performed behaviors, the total score (compulsions and obsessions subscales) was used in the final cluster analysis. The total score integrates complex composite features ( thoughts and behaviors ) of compulsivity [ 62 – 65 ] in order to investigate the natural organization of associated psychological, cognitive, and neurobiological processes. Moreover, obsessions and compulsions tend to cluster together and there is often limited utility in differentiating them [ 66 , 67 ].…”

Section: Methodsmentioning

confidence: 99%

Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing

et al. 2022

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Compulsivity is a poorly understood transdiagnostic construct thought to underlie multiple disorders, including obsessive-compulsive disorder, addictions, and binge eating. Our current understanding of the causes of compulsive behavior remains primarily based on investigations into specific diagnostic categories or findings relying on one or two laboratory measures to explain complex phenotypic variance. This proof-of-concept study drew on a heterogeneous sample of community-based individuals (N = 45; 18–45 years; 25 female) exhibiting compulsive behavioral patterns in alcohol use, eating, cleaning, checking, or symmetry. Data-driven statistical modeling of multidimensional markers was utilized to identify homogeneous subtypes that were independent of traditional clinical phenomenology. Markers were based on well-defined measures of affective processing and included psychological assessment of compulsivity, behavioral avoidance, and stress, neurocognitive assessment of reward vs. punishment learning, and biological assessment of the cortisol awakening response. The neurobiological validity of the subtypes was assessed using functional magnetic resonance imaging. Statistical modeling identified three stable, distinct subtypes of compulsivity and affective processing, which we labeled “Compulsive Non-Avoidant”, “Compulsive Reactive” and “Compulsive Stressed”. They differed meaningfully on validation measures of mood, intolerance of uncertainty, and urgency. Most importantly, subtypes captured neurobiological variance on amygdala-based resting-state functional connectivity, suggesting they were valid representations of underlying neurobiology and highlighting the relevance of emotion-related brain networks in compulsive behavior. Although independent larger samples are needed to confirm the stability of subtypes, these data offer an integrated understanding of how different systems may interact in compulsive behavior and provide new considerations for guiding tailored intervention decisions.

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“…The presence of compulsions, which are stereotyped behaviors conducted following rigid rules and performed to decrease or avoid unpleasant consequences (Chamberlain et al, 2009 ), is the core feature observed in obsessive-compulsive disorder (OCD), which affects between 1.1 and 1.8% of the population internationally (American Psychiatric Association, 2013 ). Nowadays, compulsivity could be considered a transdiagnostic trait, which may be a problem for traditional diagnostic systems, prevention, and treatment (Den Ouden et al, 2020 ). In this sense, as a result of neuroscience insights (for a review, see Fineberg et al, 2018 ), the diagnostic classification systems DSM-5 (American Psychiatric Association, 2013 ) and ICD-11 (World Health Organization, 2018 ) have removed OCD from the anxiety disorder grouping, and it now stands at the head of a new family of obsessive-compulsive spectrum disorders (otherwise known as obsessive-compulsive and related disorders, OCRDs), including body dysmorphia, hoarding, hair-pulling, skin picking and olfactory reference disorders, and hypochondriasis, all sharing compulsive behavior as a cardinal characteristic (Fineberg et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Behavioral domains in compulsive rats: implications for understanding compulsive spectrum disorders

Martín-González

Olmedo-Córdoba

Prados-Pardo

et al. 2023

Front. Behav. Neurosci.

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IntroductionCompulsive behavior has been proposed as a transdiagnostic trait observed in different neuropsychiatric disorders, such as obsessive-compulsive disorder, autism, and schizophrenia. Research Domain Criteria (RDoC) strategy could help to disentangle the neuropsychological basis of compulsivity for developing new therapeutic and preventive approaches. In preclinical research, the selection of high-drinker (HD) vs. low-drinker (LD) animals by schedule-induced polydipsia (SIP) is considered a putative model of compulsivity, which includes a well-differentiated behavioral pattern.MethodsThe purpose of this research was to assess the cognitive control and the negative valence system domains in a phenotype of compulsive HD rats. After the selection of animals as HD or LD, we assessed behavioral inflexibility by probabilistic spatial reversal learning (PSRL), motor and cognitive impulsivity by variable delay-to-signal (VDS), and risky decision-making by rodent gambling task (rGT).ResultsHD rats performed fewer reversals and showed less probability of pressing the same lever that was previously reinforced on PSRL, more premature responses after the exposure to longer delays on VDS, and more disadvantageous risky choices on rGT. Moreover, HD animals performed more perseverative responses under the punishment period on rGT.DiscussionThese results highlight that HD compulsive phenotype exhibits behavioral inflexibility, insensitivity to positive feedback, waiting impulsivity, risky decision-making, and frustrative non-reward responsiveness. Moreover, these findings demonstrate the importance of mapping different behavioral domains to prevent, treat, and diagnose compulsive spectrum disorders correctly.

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The role of Experiential Avoidance in transdiagnostic compulsive behavior: A structural model analysis

Cited by 16 publications

References 76 publications

Lifestyle risk factors for obsessive-compulsive symptoms and related phenomena: What should lifestyle interventions target?

Lifestyle risk factors for obsessive-compulsive symptoms and related phenomena: What should lifestyle interventions target?

Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing

Behavioral domains in compulsive rats: implications for understanding compulsive spectrum disorders

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