The role of fibrin E on the modulation of endothelial progenitors adhesion, differentiation and angiogenic growth factor production and the promotion of wound healing

Caiado, Francisco; Carvalho, Tânia; Silva, Fernanda; Castro, Catarina; Clode, Nuno; Dye, Julian F.; Dias, Sérgio

doi:10.1016/j.biomaterials.2011.06.022

Cited by 66 publications

(40 citation statements)

References 37 publications

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“…We observed that EPCs grown or gelatin, FN or on fibrin proteolytic fragment E (FbnE) express different levels of multiple paracrine factors. They showed higher expression of VEGF-A, transforming growth factor β1, SDF-1, IL-8 and macrophage inflammatory protein-1α, however the precise mechanism downstream of the interaction between integrin α5β1 and FbnE was not established [54]. …”

Section: Reviewmentioning

confidence: 99%

Endothelial progenitor cells and integrins: adhesive needs

Caiado

Dias

2012

Fibrogenesis Tissue Repair

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105

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In the last decade there have been multiple studies concerning the contribution of endothelial progenitor cells (EPCs) to new vessel formation in different physiological and pathological settings. The process by which EPCs contribute to new vessel formation in adults is termed postnatal vasculogenesis and occurs via four inter-related steps. They must respond to chemoattractant signals and mobilize from the bone marrow to the peripheral blood; home in on sites of new vessel formation; invade and migrate at the same sites; and differentiate into mature endothelial cells (ECs) and/or regulate pre-existing ECs via paracrine or juxtacrine signals. During these four steps, EPCs interact with different physiological compartments, namely bone marrow, peripheral blood, blood vessels and homing tissues. The success of each step depends on the ability of EPCs to interact, adapt and respond to multiple molecular cues. The present review summarizes the interactions between integrins expressed by EPCs and their ligands: extracellular matrix components and cell surface proteins present at sites of postnatal vasculogenesis. The data summarized here indicate that integrins represent a major molecular determinant of EPC function, with different integrin subunits regulating different steps of EPC biology. Specifically, integrin α4β1 is a key regulator of EPC retention and/or mobilization from the bone marrow, while integrins α5β1, α6β1, αvβ3 and αvβ5 are major determinants of EPC homing, invasion, differentiation and paracrine factor production. β2 integrins are the major regulators of EPC transendothelial migration. The relevance of integrins in EPC biology is also demonstrated by many studies that use extracellular matrix-based scaffolds as a clinical tool to improve the vasculogenic functions of EPCs. We propose that targeted and tissue-specific manipulation of EPC integrin-mediated interactions may be crucial to further improve the usage of this cell population as a relevant clinical agent.

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Section: Reviewmentioning

confidence: 99%

Endothelial progenitor cells and integrins: adhesive needs

Caiado

Dias

2012

Fibrogenesis Tissue Repair

Self Cite

112

105

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“…FXIIa stimulates the fibrinolytic system further through activation of FXI and prekallikrein, since the formed enzymes are also plasminogen activators [2,4,5]. Even after clot formation and fibrinolysis, FXIIa and the proteins of the fibrinolytic system participate in the same processes, since tPA and fibrin fragment E, a fibrin degradation product formed during fibrinolysis, enhance angiogenesis [24,25]. Moreover, binding of FXII to the urokinase plasminogen activator receptor (uPAR) initiates angiogenesis via stimulation of ERK1/2 and Akt [26].…”

Section: Discussionmentioning

confidence: 97%

The role of activated coagulation factor XII in overall clot stability and fibrinolysis

Konings

Hoving

Ariëns

et al. 2015

Thrombosis Research

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“…Finally, in contrast to the process of differentiation, EPCs affect the angiogenic process through production of paracrine factors, which are dynamically regulated by different ECM substrates. For instance, gelatin, fibronectin, and fibrin proteolytic fragment E promote expression of VEGF, TGF-β1, stromal-cell derived factor (SDF)-1, and interleukin (IL)-8, which in turn facilitate EC tube formation and wound healing [129]. However, recent findings uncovered alternative ways of how tumors increase their vascular supply and promote oncogenic signaling, and ECM components seem to be critical for these processes.…”

Section: Endothelial Progenitor Cellsmentioning

confidence: 98%

More than a Scaffold: Extracellular Matrix in Vascular Signaling

Nikolić

2015

Endothelial Signaling in Development and Disease

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The role of fibrin E on the modulation of endothelial progenitors adhesion, differentiation and angiogenic growth factor production and the promotion of wound healing

Cited by 66 publications

References 37 publications

Endothelial progenitor cells and integrins: adhesive needs

Endothelial progenitor cells and integrins: adhesive needs

The role of activated coagulation factor XII in overall clot stability and fibrinolysis

More than a Scaffold: Extracellular Matrix in Vascular Signaling

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