L ife expectancy in the United States (US) rose nearly every year between 1943 and 2014, 1 but between 2014 and 2017 the country experienced the longest sustained decline since 1915-18. 2-5 Much of the decline has been attributed to the drug epidemic. 5-8 Increased availability of opioids resulting from changes in marketing, prescribing, and insurance coverage of prescription opioids, which led to wider black market dissemination of heroin, fentanyl, and other opioids almost certainly contributed to growing drug abuse. 9-12 Indeed, drug-related mortality has increased dramatically in the US: the age-adjusted rate in 2017 (21.7 per 100,000) was 3.6 times that in 1999 (6.1 per 100,000). 13 But the US mortality crisis may extend beyond the drug epidemic. Some researchers have noted that alcohol-related mortality and suicides also increased since the late 1990s. 14,15 Recognition of these shared trends inspired the term "deaths of despair" 16-18 to refer to the cluster of suicides and alcohol-related and drug-related mortality. Other evidence suggests that midlife Americans in particular are afflicted with rising mortality across a variety of causes. Among those aged 25-64, mortality rates increased between 1999 and 2016, not only for external causes, but also digestive diseases, endocrine/nutritional/metabolic disorders, and diseases of the nervous system. 19 These disturbing trends have led scholars to speculate that the US mortality crisis stems from a deeper malaise: a rising tide of despair, 20-22 particularly among less-educated, middle-aged Americans. 14,15 Case and Deaton 14 hypothesized that changes in labor market opportunities have triggered growing distress. Job prospects for less-educated Americans have steadily deteriorated since the early 1970s. 14,15,22 Socioeconomically disadvantaged Americans also