The role of fine needle aspiration cytology and core biopsy in the diagnosis of palpable breast masses

Kocaay, Akın Fırat; Çelik, Süleyman Utku; Sevim, Yusuf; Ozyazici, Sefa; Çetinkaya, Ömer Arda; Alic, Kamil Bulent

doi:10.4103/0300-1652.182078

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…FNAC is simple, quick, cost-effective, and relatively painless procedure. FNAC is good for larger lesions but for low-grade malignancies and papillary lesions, it might be difficult [7]. The sensitivity of FNAC varies from 35% to 95% and specificity varies from 48 to 100% [8-12].…”

Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration Cytology versus Core-Needle Biopsy for Breast Lesions: A Dilemma of Superiority between the Two

Verma

Sharma²,

Sharma

et al. 2021

Acta Cytologica

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Introduction: Core-needle biopsy (CNB) is a minimally invasive procedure used in preoperative diagnosis of breast lumps. It has been seen that in few years, the CNB seems to be replacing the fine-needle aspiration cytology (FNAC), although no study had yet conclusively proved a superiority of one over the other. Aims and Objectives: The aim of this study was to study the cytohistological spectrum of palpable breast lesions and to evaluate the diagnostic accuracy of FNAC versus CNB for breast lesions. Materials and Methods: The study was a cross-sectional study conducted in the Department of Pathology and Surgery, over a period of 1 year in 152 patients. All the patients were subjected to FNAC and CNB. Cytosmears were stained with May-Grunwald Giemsa and hematoxylin and eosin was done on CNB and excision biopsy (EB) specimens. Sensitivity and specificity were calculated in percentage with 95% confidence interval with reference to CNB/surgical specimens. Kappa statistics were used to compare the level of agreement between FNAC versus CNB and CNB versus surgical specimens. Results: A total of 152 patients were taken for FNAC and CNB. EB was performed in only 104 patients. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FNAC verses CNB in correlation with subsequent histopathology were found to be (93.40 vs. 94.06%), (97.50 vs. 100.00%), (99.00 vs. 100.00%), (84.78 vs. 33.33%), and (94.52 vs. 94.23%), respectively. Conclusion: CNB has overcome the pitfall of FNAC but CNB cannot replace FNAC but both procedures are complementary to each other.

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Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration Cytology versus Core-Needle Biopsy for Breast Lesions: A Dilemma of Superiority between the Two

Verma

Sharma²,

Sharma

et al. 2021

Acta Cytologica

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“…Fine needle aspiration cytology has been established as an important tool in the evaluation of breast lesions ever since it was first introduced by Martin and Ellis in the first half of twentieth century. It has been a preferred technique of preoperative diagnosis for breast pathologies in areas where resources are limited [ 3 , 10 – 12 ]. To the best of our knowledge, there is paucity of published data in our country that characterize the distribution of breast lesions diagnosed by FNAC.…”

Section: Discussionmentioning

confidence: 99%

“…Excisional biopsy represents a traditional means of breast mass diagnosis which provides a relatively precise diagnostic impression, albeit unnecessarily invasive considering the likelihood of a benign pathological condition in many cases. On the contrary, fine needle aspiration cytology (FNAC) of the breast is deemed to be a minimally invasive, quick, cost-effective and easy to perform procedure often avoiding an open biopsy [ 3 , 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Distribution of breast lesions diagnosed by cytology examination in symptomatic patients at Eritrean National Health Laboratory, Asmara, Eritrea: a retrospective study

et al. 2020

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Background Fine needle aspiration cytology is a simple, relatively accurate, non-invasive, and cost-effective method of diagnosing most breast pathologies. To date, there is no sufficient data depicting the distribution of breast lesions detected by fine needle aspiration cytology in our healthcare setting. The aim of this study was to elucidate the general distribution of breast lesions diagnosed by cytology test at Eritrean National Health Laboratory. Methods This retrospective study was carried out on 905 symptomatic patients between the years 2013 and 2017 at Eritrean National Health Laboratory. Diagnosis was made by fine needle aspiration cytology in patients with palpable breast lump and in some patients direct smear was prepared from a nipple discharge. Statistical analysis was carried out using Statistical Package for the Social Sciences version 23. Results A total of 905 patients were included in the study, of whom 871 (96.24%) were females. The age range of patients was from 13 to 93 years with mean and standard deviation of 33 ± 14.9 years. Breast lump, occurring in 892 (98.56%), was the most frequent presenting symptom. Fibroadenoma and fibrocystic breast lesions were the most prevalent lesions accounting for approximately 40% and 15%, respectively. Malignant breast lesions were seen predominantly in females above the age of 40 years with the highest frequency observed in the age range between 51 and 60 years. Pearson Chi-squared test showed significant association between patients’ age above 40 years and the risk of having a malignant breast lesion (p < 0.001). The highest number of benign and malignant breast lesions was documented in 2014 with little fluctuation elsewhere in the study period. Conclusion Fine needle aspiration cytology is a procedure of choice for preoperative diagnosis in breast lesions mainly in a resource-limited settings. Our study identified the occurrence of malignant breast lesions in young women, which is of a paramount public health concern. Of note, significant proportion of patients were late to seek medical attention. Therefore, enhancement of community awareness regarding breast disease and implementation of screening programs are necessary to ameliorate the morbidity and mortality associated with the disease.

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“…For evaluation of malignancy or benign conditions of breast lesion cytological or pathological diagnosis is valuable (9). Fine needle aspiration (FNAC), scraping of skin (SS) and smearing of nipple discharge (ND) is the usual ways the breast lesions are investigated cytologically.…”

Section: Introductionmentioning

confidence: 99%

Cytomorphological Patterns of Palpable Breast Lesions Diagnosed on Fine Needle Aspiration Cytology in Jimma Hospital, Ethiopia

Abera

Angaw

Bezabih

et al. 2020

Preprint

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Background: Breast cancer is the most common cancer in women worldwide, in 2012 with nearly 1.7 million new cases were diagnosed. This represents about 12% of all new cancer cases and 25% of all cancers in women. In low and middle-income countries (LMCs), the infrastructure and resources for routine screening mammography are often unavailable.Objective: The objective of this study focused on determining the cytomorphologic patterns of palpable breast lesions in Jima University Specialized Hospital.Methods: A descriptive cross-sectional study was done on breast FNAC medical records. Analysis was done using SPSS version 20. Chi square test was applied to check the significant effect of independent variables on the dependent variables.Result: In this study 735 patients were included and the overall distribution of the lesion was benign neoplastic (51%), non-neoplastic (28%), malignancy (17%) and suspicious (4%). The most common lesions in male were non-neoplastic and in female were benign neoplastic groups. The majority of (49.3%) breast lesions were located in the left breast followed by right breast (43.9%).Conclusion: This study supports the usefulness of cytomorphological diagnostic techniques in the workout of breast lesions, confirms the predominance of benign breast lesions in the young and the occurrence of age independency in malignancy.

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The role of fine needle aspiration cytology and core biopsy in the diagnosis of palpable breast masses

Cited by 8 publications

References 24 publications

Fine-Needle Aspiration Cytology versus Core-Needle Biopsy for Breast Lesions: A Dilemma of Superiority between the Two

Fine-Needle Aspiration Cytology versus Core-Needle Biopsy for Breast Lesions: A Dilemma of Superiority between the Two

Distribution of breast lesions diagnosed by cytology examination in symptomatic patients at Eritrean National Health Laboratory, Asmara, Eritrea: a retrospective study

Cytomorphological Patterns of Palpable Breast Lesions Diagnosed on Fine Needle Aspiration Cytology in Jimma Hospital, Ethiopia

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