The role of G-CSF and IL-6 in the granulopoiesis-stimulating activity of murine blood serum induced by perorally administered ultrafiltered pig leukocyte extract, IMUNOR®

Vácek, A; Höfer, Milan; Holá, Jarmila; Weiterová, Lenka; Štreitová, Denisa; Svobodá, J.

doi:10.1016/j.intimp.2007.01.011

Cited by 10 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DLE generally known as TF, is immunotherapy agent that demonstrated ability to improve immunological response in cancer patients [43,44]. The studies with DLE as adjuvant therapy have continually reported improvement in clinical response to treatment [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

Int J Immunol Immunother

View full text Add to dashboard Cite

Immune Modulating Peptides (IMP) discussed in literature as a universal immunocorrectors with wide areas of usage which balance the immune system without causing global immune suppression or overreaction. The present article aim is to review the effect and drawbacks of IMPs in form of Dialyzable leukocyte Extracts (DLE) or Transfer Factors (TF) during and following chemotherapy, radiotherapy, drugs interactions, cancer response and clinical outcomes in different cases of cancers such as metastatic breast cancer, glioma, prostate cancer, osteosarcoma and others. The considered cases of immune overreaction and IMP's impact include autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and allergic reactions. The most difficult therapeutic decision is to choose the right treatment for patients with cancer and autoimmune diseases as they both attempt to supervise and control the immune system, managing immune cells in opposite sides. As patients with autoimmune disease experience difficulty to stay in such treatment when immune cells stimulated in order to identify and destroy cancer cells the IMP as immunocorrectors become one of the main and only healthy choices. The universal mechanism of IMPs action and the absence of contraindications extend the indications for their use in pediatric practice. This includes the complex treatment of respiratory viral infections, the possibility of using in frequently ill children with clinical signs of immune dysfunction and acute intestinal infections. According to the reports on safety, absence of adverse and side effects along with positive outcome for patients the IMPs considered as valuable immunocorrector.

show abstract

Section: Discussionmentioning

confidence: 99%

Untitled

2019

Int J Immunol Immunother

View full text Add to dashboard Cite

show abstract

“…34,35) Meanwhile, as major HGFs, GM-CSF and IL-6 work on cells responsible for the systemic immunity through the PPs. 36,37) These facts lead us to conclude that KBV-CP might stimulate not only the mucosal immune system but also the systemic immune system when taken orally. Our results are consistent with a previous report demonstrating that Korean persimmon vinegar-derived polysaccharide stimulates the intestinal immune system via not only IgA production related to TGF-β and IL-6 secretion, but also through hematopoietic activity related to GM-CSF and IL-6.…”

Section: Transepithelial Transport Of Kbv-cp Using Intestinal Co-cultmentioning

confidence: 98%

Intestinal immunostimulatory activity of neutral polysaccharide isolated from traditionally fermented Korean brown rice vinegar

Kim

Lee

Shin

2016

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

In this study, diverse intestinal immunostimulatory activities were demonstrated for polysaccharides (KBV-CP) isolated from Korean brown rice vinegar. Monosaccharide composition analysis indicated that KBV-CP was composed mainly of neutral sugar units, primarily glucose and mannose. In vitro, KBV-CP significantly augmented the productions of immunoglobulin A (IgA) and IgA-related cytokines such as interleukin-6 (IL-6) and transforming growth factor-β (TGF-β) in a dose-dependent manner. Furthermore, results of an in vitro co-culture system of intestinal Caco-2 cells and RAW 264.7 macrophage cells suggested that KBV-CP is not only cytotoxic to Caco-2 cells but also capable of being transported across the small intestinal barrier. Oral administration of KBV-CP every other day for 20 days induced the IgA production by Peyer's patch cells as well as in intestinal fluid and fecal extract. In addition, the production of IgA-related cytokines such as TGF-β and IL-6, and granulocyte macrophage colony-stimulating factor was triggered.

show abstract

“…At the same time, we performed a re-evaluation of bone marrow aspirate, identifying post-chemotherapy aplasia without evidence of blasts. We performed therapy with subcutaneous colony-stimulating growth factors (G-CSF) [ 10 ].…”

Section: Case Presentationmentioning

confidence: 99%

Saprochete capitata: Emerging Infections from Uncommon Microorganisms in Hematological Diseases

et al. 2022

View full text Add to dashboard Cite

Infections occurring in immunocompromised patients after intensive chemotherapy are often difficult to eradicate and are capable of even being fatal. New emergent and dangerous drug-resistant micro-organisms are likely to appear in these specific scenarios. Clinical features mainly include progressive pneumonia, bacteriemia/fungemia, or extrapulmonary dissemination among infections. The treatment of these microorganisms is still an open challenge since there is a lack of clear treatment guidelines. Indeed, infections from these microorganisms can lead to a rapidly fatal clinical course in immunocompromised patients, especially those who have acute leukemia. We describe the case of a young patient with acute myeloid leukemia who contracted an infection from Saprochaete capitata during post-chemotherapy aplasia.

show abstract

The role of G-CSF and IL-6 in the granulopoiesis-stimulating activity of murine blood serum induced by perorally administered ultrafiltered pig leukocyte extract, IMUNOR®

Cited by 10 publications

References 15 publications

Untitled

Untitled

Intestinal immunostimulatory activity of neutral polysaccharide isolated from traditionally fermented Korean brown rice vinegar

Saprochete capitata: Emerging Infections from Uncommon Microorganisms in Hematological Diseases

Contact Info

Product

Resources

About