The role of galectins in obstetrics with particular emphasis on premature preterm rupture of membranes

Kolanowska, Dorota; Swietlicki, Aleksy; Drews, Krzysztof; Seremak‐Mrozikiewicz, Agnieszka

doi:10.5603/gp.a2021.0187

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The risk of premature rupture of the membranes is directly related to the number of interventions, as well as advanced fetal surgery type and uterine incision size [8][9][10]. Obstetricians should choose appropriate instruments and be familiar with the procedure to reduce the operating time.…”

Section: Discussionmentioning

confidence: 99%

Maternal and fetal benefits of fetal reduction in triplet pregnancies

Zhang

et al. 2023

Arch Med Sci

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IntroductionTriplet pregnancy is a type of high-risk pregnancy that often results in premature delivery. Although fetal reduction is recommended, a number of factors can lead to triplet pregnancies without reduction. As there is no consensus on reduction, it is necessary to carry out a specific evaluation of the benefits of reduction in triplet pregnancy. This study was performed to evaluate and discuss the prognosis of triplet pregnancy with or without fetal reduction.Material and methodsClinical data from 24 women with triplet pregnancies were retrospectively collected and analyzed. Twelve women underwent fetal reduction (fetal reduction group) and 12 women continued triplet pregnancy (non-fetal reduction group). In the fetal reduction group, four dichorionic triamniotic triplets were reduced to dichorionic diamniotic twins (with a reduction of one of the monochorionic diamniotic fetuses); six trichorionic triamniotic triplets were reduced to dichorionic diamniotic twins (with a reduction of one monochorionic monoamniotic fetus).ResultsThere were significant differences in the incidence of premature rupture of membranes and neonatal hypoglycemia between the reduction and non-reduction groups. The average birth weight was significantly different between the reduction group and non-reduction group. The Apgar score was significantly different between the monochorionic monoamniotic reduction group and monochorionic diamniotic reduction group.ConclusionsTriplet pregnancy should be closely monitored throughout pregnancy and the perinatal period, regardless of fetal reduction. The chorionicity should be considered with fetal reduction. Compared with the mother, the remaining fetuses may benefit more from fetal reduction, especially in terms of neonatal weight.

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Section: Discussionmentioning

confidence: 99%

Maternal and fetal benefits of fetal reduction in triplet pregnancies

Zhang

et al. 2023

Arch Med Sci

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“…However, the key molecular mechanism of fetal membranes to heal wounds after spontaneous or iatrogenic membrane rupture still remains unknown. Previous researches have demonstrated that galectins are a key player in the membrane healing process such as the healing of skin and cornea ( 11 , 12 ), nonetheless, although galectins are overexpressed on fetal membranes in patients with PROM ( 13 , 14 ), their function in fetal membrane healing is still unidentified. In this review, we will present the current knowledge on fetal membrane wound healing and discuss the possible role galectins may play in for the development of clinical solution to improve healing of the fetal membranes.…”

Section: Introductionmentioning

confidence: 99%

Possible important roles of galectins in the healing of human fetal membranes

Chen

Chen²,

et al. 2022

Front. Endocrinol.

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The fetal membranes healing is a complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers. Multiple cells and extracellular matrices, and cell differentiation, migration and proliferation may participate in restoring the integrity of damaged tissue, however this process still remains unclear. Therefore, there is a need to identify and integrate new ideas and methods to design a more effective dressing to accelerate fetal membrane healing. This review explores the function and role of galectins in the inflammatory, epithelial mesenchymal transition, proliferative migration, and remodeling phases of fetal membrane healing. In conclusion, the preliminary findings are promising. Research on amnion regeneration is expected to provide insight into potential treatment strategies for premature rupture of membranes.

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Galectin-7 Expression in the Placentas of Women with Gestational Diabetes Mellitus

Seifert,

Unverdorben,

Knabl

et al. 2024

IJMS

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Gestational diabetes mellitus (GDM) is a common condition during pregnancy. The prevalence of GDM is continuously increasing worldwide. Due to accessible diagnostic methods and a clear understanding of risk factors, GDM can be effectively diagnosed and managed. Galectins may influence immunomodulatory and inflammatory processes. This study examines the expression of galectin-7 in the placentas of women with gestational diabetes (GDM), compares it to its expression in healthy pregnancies, and evaluates the associated clinical outcomes. The placentas of 40 healthy women and 40 GDM placentas were included in the cohort. The expression level of galecin-7 was measured in the syncytiotrophoblast (SCT) and in the decidua of the placenta by immunohistochemistry and double immunofluorescence staining. The evaluation was performed by an immunoreactivity score (IRS). The study results show an increased expression of galectin-7 in the SCT and the decidua of GDM placentas as compared to the placentas of the control group. Elevated levels of galectin-7 were observed in both the nucleus and the cytoplasm. This study investigated the hypothesis that galectins are involved in pathophysiological processes of gestational diabetes. Statistical analysis of gene expression patterns confirmed that galectin-7 is indeed upregulated in GDM placentas. Further studies are needed to show the correlation of galectin-7 and the development and maintenance of gestational diabetes mellitus.

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The role of galectins in obstetrics with particular emphasis on premature preterm rupture of membranes

Cited by 3 publications

References 34 publications

Maternal and fetal benefits of fetal reduction in triplet pregnancies

Maternal and fetal benefits of fetal reduction in triplet pregnancies

Possible important roles of galectins in the healing of human fetal membranes

Galectin-7 Expression in the Placentas of Women with Gestational Diabetes Mellitus

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